Is the step-wise tiered approach for ERA of pharmaceuticals useful for the assessment of cancer therapeutic drugs present in marine environment?

Aguirre-Martínez, G.V.; Okello, Cornelius; Salamanca, María José; Garrido, Carmen; DelValls, T.À.; Martı́n-Dı́az, M.L.

doi:10.1016/j.envres.2015.10.028

Cited by 19 publications

(5 citation statements)

References 98 publications

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“…The ecological risks of both compounds were assessed based on measured environmental concentration (MEC) and the predicted no-effect concentration (PNEC) index. In these assessments, MTX was not found to be harmful to the marine species tested and was thus found to pose no risk to the environment (Aguirre-Martínez et al, 2016). Environmental concentrations of NOV, however, were found to pose ecological risks (Aguirre-Martínez et al, 2015).…”

Section: Resultsmentioning

confidence: 97%

“…As is the case of geochemical behavior, there are few studies addressing the toxicity of these two compounds in marine organisms, especially using sediment samples, which makes further comparison of the results unfeasible. Aguirre-Martínez et al (2016) assessed acute toxicity of MTX in seawater samples using bioluminescence analysis on Aliivibrio fischeri. They also assessed growth inhibition of the microalga Isochrysis galbana and embryo-larval development of the sea urchin Paracentrotus lividus.…”

Section: Resultsmentioning

confidence: 99%

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Effects of novobiocin and methotrexate on the benthic amphipod Ampelisca brevicornis exposed to spiked sediments

Moreira

Maranho

Baena-Nogueras

et al. 2016

Marine Environmental Research

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The marine amphipod Ampelisca brevicornis was used as model organism of benthic macrofauna to assess the possible adverse effects of pharmaceuticals bound to sediments. Organisms were exposed to sediment spiked with novobiocin (NOV) and methotrexate (MTX) for 10 days in order to estimate the acute toxicity (lethal effects) produced by the two compounds. The surviving organisms were pooled and analyzed to determine their sublethal responses associated with different phases of metabolism (enzyme activities in phases I and II), oxidative stress (antioxidant enzyme activities and lipid peroxidation), and genotoxicity (DNA damage in the form of strand breaks). No lethal or sublethal effects were observed in the amphipods exposed to NOV. For organisms exposed to sediments spiked with MTX the results were found to calculate the concentration that was lethal to 50% of the organisms exposed in the toxicity tests (LC of 30.36 ng/g). MTX also induced the metabolism of enzyme detoxification activities in phases I and II. Oxidative stress and DNA damage in particular were also observed, indicating responses associated with MTX's mechanism of action. Both mortality and the set of applied biomarkers allowed for the assessment of bioavailability, oxidative stress, and genotoxicity of NOV and MTX. The information obtained in this investigation can assist in ecological risk assessment of marine sediments contaminated by pharmaceuticals.

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Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Effects of novobiocin and methotrexate on the benthic amphipod Ampelisca brevicornis exposed to spiked sediments

Moreira

Maranho

Baena-Nogueras

et al. 2016

Marine Environmental Research

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“…However, the EMEA guideline requires that only newly authorized pharmaceuticals should be evaluated, which does not include most of the anticancer drugs that were on the market before 2006. Thus, Aguirre‐Martínez et al (2016) conducted a risk assessment of tamoxifen and methotrexate for marine species following the EMEA guideline and evaluated the feasibility of including a biomarkers approach in Phase 3 of the environmental risk assessment. An antimetabolite used as a chemotherapeutic drug, methotrexate acts by preventing the formation and replication of DNA, thereby inhibiting the growth of cancer cells (Evans et al, 1982).…”

Section: Effects Of Anticancer Drugs On Marine Invertebratesmentioning

confidence: 99%

Environmental Hazard of Anticancer Drugs: State of the Art and Future Perspective for Marine Organisms

Ribeiro

Lotufo

Loureiro

et al. 2022

Enviro Toxic and Chemistry

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Pharmaceutical compounds represent a class of emerging contaminants present in the environment. Their intense (and increasing) use in human and veterinary medicine leads to their discharge, mainly via human excretion, into wastewater treatment plants where their removal is inefficient. A specific class of pharmaceuticals used to fight cancer, known as antineoplastic or anticancer drugs, has gained increased attention regarding their possible environmental hazard due to their pharmacological properties, which include the nonselective targeting of DNA replication mechanisms and cell division processes, potentially inducing cell apoptosis. To date, there is limited information concerning the effects of anticancer drugs and/or their metabolites in species inhabiting freshwater environments, let alone marine and estuarine compartments. In the present review, we aimed to assemble information regarding the impact that anticancer drugs have on biological traits of marine species, to identify gaps in the current environmental hazard assessment, and to make recommendations to promote an efficient environmental hazard assessment of anticancer drugs in the marine environment. Environ Toxicol Chem 2022;41:1793–1807. © 2022 SETAC

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“…Tamoxifen, which has been extensively studied in different aquatic species, has caused bioluminescence inhibition of bacteria with EC 50 = 330 mg/L (Aguirre- Martínez et al, 2016).…”

Section: Hormone Antagonists and Related Agentsmentioning

confidence: 99%

Aquatic ecotoxicology of anticancer drugs: A systematic review

Nassour

Nabhani‐Gebara

Barton

et al. 2021

Science of The Total Environment

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Is the step-wise tiered approach for ERA of pharmaceuticals useful for the assessment of cancer therapeutic drugs present in marine environment?

Cited by 19 publications

References 98 publications

Effects of novobiocin and methotrexate on the benthic amphipod Ampelisca brevicornis exposed to spiked sediments

Effects of novobiocin and methotrexate on the benthic amphipod Ampelisca brevicornis exposed to spiked sediments

Environmental Hazard of Anticancer Drugs: State of the Art and Future Perspective for Marine Organisms

Aquatic ecotoxicology of anticancer drugs: A systematic review

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