Aquatic ecotoxicology of anticancer drugs: A systematic review

Nassour, Carla; Nabhani‐Gebara, Shereen; Barton, S.K.; Barker, James

doi:10.1016/j.scitotenv.2021.149598

Cited by 16 publications

(11 citation statements)

References 142 publications

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“…Due to the stability of certain drugs, the ecotoxicity of metabolites, the accumulation and amplification effect in the food chain and the low removal efficiency of wastewater treatment plants, drugs discharged into the environment will have adverse effects on aquatic organisms. 6,13,14 Tyrosine kinase inhibitors inhibit tumor growth by blocking intracellular protein phosphorylation signals. 15 Topoisomerase inhibitor irinotecan (IRI) can be detected in hospital wastewater, but it can be effectively removed by wastewater treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The abuse of drugs has increased in some regions and the drugs enter the water environment through animal and human excretion, improper human medical waste operations. Due to the stability of certain drugs, the ecotoxicity of metabolites, the accumulation and amplification effect in the food chain and the low removal efficiency of wastewater treatment plants, drugs discharged into the environment will have adverse effects on aquatic organisms 6,13,14 . Tyrosine kinase inhibitors inhibit tumor growth by blocking intracellular protein phosphorylation signals 15 .…”

Section: Discussionmentioning

confidence: 99%

“…It reasoned that there might be developmental toxic effects of these drugs on target organisms in water bodies. 6 Therefore, the toxic and related mechanisms of lenvatinib need to be evaluated.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the detection of antineoplastic drugs in water has raised increasing safety concerns on aquatic organisms. It reasoned that there might be developmental toxic effects of these drugs on target organisms in water bodies 6 . Therefore, the toxic and related mechanisms of lenvatinib need to be evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Liu

Huang

Wan

et al. 2022

Environmental Toxicology

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Due to an increasing number of abused drugs dumped into the wastewater, more and more drugs are detected in the water environment, which may affect the survival of aquatic organisms. Lenvatinib is a multi-targeted tyrosine kinase inhibitor, and is clinically used to treat differentiated thyroid cancer, renal epithelial cell carcinoma and liver cancer. However, there are few reports on the effects of lenvatinib in embryos development. In this study, zebrafish embryos were used to evaluate the effect of lenvatinib on cardiovascular development. Well-developed zebrafish embryos were selected at 6 h post fertilization (hpf) and exposed to 0.05 mg/L, 0.1 mg/L and 0.2 mg/L lenvatinib up to 72 hpf. The processed embryos demonstrated cardiac edema, decreased heart rate, prolonged SV-BA distance, inhibited angiogenesis, and blocked blood circulation. Lenvatinib caused cardiac defects in the whole stage of cardiac development and increased the apoptosis of cardiomyocyte.Oxidative stress in the processed embryos was accumulated and inhibiting oxidative stress could rescue cardiac defects induced by lenvatinib. Additionally, we found that lenvatinib downregulated Notch signaling, and the activation of Notch signaling could rescue cardiac developmental defects and downregulate oxidative stress level induced by lenvatinib. Our results suggested that lenvatinib might induce cardiac developmental toxicity through inducing Notch mediated-oxidative stress generation, raising concerns about the harm of exposure to lenvatinib in aquatic organisms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Liu

Huang

Wan

et al. 2022

Environmental Toxicology

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“…The environmental distribution of platinum-based anticancer drugs and their metabolites are particularly poorly defined [99]. A recent review analyzing data from numerous studies on CDs toxic effects evidenced that toxicity was also dependent on the compound and the organism, and that multi-generational exposure was more important to recognize the impact of CDs, which at environmental concentrations do not seem to be harmful [100].…”

Section: Ecotoxicological Potencymentioning

confidence: 99%

The Dark Side of Platinum Based Cytostatic Drugs: From Detection to Removal

et al. 2021

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The uncontrolled release of pharmaceutical drugs into the environment raised serious concerns in the last decades as they can potentially exert adverse effects on living organisms even at the low concentrations at which they are typically found. Among them, platinum based cytostatic drugs (Pt CDs) are among the most used drugs in cancer treatments which are administered via intravenous infusion and released partially intact or as transformation products. In this review, the studies on environmental occurrence, transformation, potential ecotoxicity, and possible treatment for the removal of platinum cytostatic compounds are revised. The analysis of the literature highlighted the generally low total platinum concentration values (from a few tens of ng L−1 to a few hundred μg L−1) found in hospital effluents. Additionally, several studies highlighted how hospitals are sources of a minor fraction of the total Pt CDs found in the environment due to the slow excretion rate which is longer than the usual treatment durations. Only some data about the impact of the exposure to low levels of Pt CDs on the health of flora and fauna are present in literature. In some cases, adverse effects have been shown to occur in living organisms, even at low concentrations. Further ecotoxicity data are needed to support or exclude their chronic effects on the ecosystem. Finally, fundamental understanding is required on the platinum drugs removal by MBR, AOPs, technologies, and adsorption.

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Environmental Hazard of Anticancer Drugs: State of the Art and Future Perspective for Marine Organisms

Ribeiro

Lotufo

Loureiro

et al. 2022

Enviro Toxic and Chemistry

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Pharmaceutical compounds represent a class of emerging contaminants present in the environment. Their intense (and increasing) use in human and veterinary medicine leads to their discharge, mainly via human excretion, into wastewater treatment plants where their removal is inefficient. A specific class of pharmaceuticals used to fight cancer, known as antineoplastic or anticancer drugs, has gained increased attention regarding their possible environmental hazard due to their pharmacological properties, which include the nonselective targeting of DNA replication mechanisms and cell division processes, potentially inducing cell apoptosis. To date, there is limited information concerning the effects of anticancer drugs and/or their metabolites in species inhabiting freshwater environments, let alone marine and estuarine compartments. In the present review, we aimed to assemble information regarding the impact that anticancer drugs have on biological traits of marine species, to identify gaps in the current environmental hazard assessment, and to make recommendations to promote an efficient environmental hazard assessment of anticancer drugs in the marine environment. Environ Toxicol Chem 2022;41:1793–1807. © 2022 SETAC

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Aquatic ecotoxicology of anticancer drugs: A systematic review

Cited by 16 publications

References 142 publications

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

Lenvatinib induces cardiac developmental toxicity in zebrafish embryos through regulation of Notch mediated‐oxidative stress generation

The Dark Side of Platinum Based Cytostatic Drugs: From Detection to Removal

Environmental Hazard of Anticancer Drugs: State of the Art and Future Perspective for Marine Organisms

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