Is the Finding of Obsessional Behaviour Relevant to the Differental Diagnosis of Vascular Dementia of the Binswanger Type?

Lawrence, Robert M.

doi:10.1155/2000/326706

Cited by 9 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The response rate in this study is similar to reported studies in Western populations, suggesting that CBT is applicable in different cultures, although the efficacy of psychotherapy is affected by cultural factors (Bhui and Morgan 2007). It is known that symptoms of OCD have varied little over time (pathological scrupulosity, for example, has long been documented) or place (similar symptoms are seen across many cultures; Ames et al 1994;Lawrence 2000). Therefore, CCT may be an applicable therapy and is worth exploring in different cultures.…”

Section: Discussionsupporting

confidence: 84%

See 1 more Smart Citation

A promising randomized trial of a new therapy for obsessive–compulsive disorder

Wen

Ma³

et al. 2012

Brain and Behavior

View full text Add to dashboard Cite

Pharmacotherapy and cognitive–behavioral therapy (CBT) are currently the most effective interventions for treating obsessive–compulsive disorder (OCD). These treatments, however, are time consuming and in some cases the patients do not show significant improvement. In all, 30%–60% of OCD patients do not respond adequately to pharmacotherapy and 20%–40% of OCD patients who complete CBT do not improve significantly, suggesting a more efficacious approach is needed. The objectives of this study are to demonstrate an efficacious pharmacotherapy plus psychotherapy, named cognitive–coping therapy (CCT), for OCD and to investigate the efficacy of this approach in a larger sample size. Therefore, a total of 108 patients with OCD were randomly allocated into three groups: pharmacotherapy (N = 38), pharmacotherapy plus CBT (PCBT, N = 34), and pharmacotherapy plus CCT (PCCT, N = 36). The severity of symptoms and the patients' functioning were assessed pretreatment and after 7, 14, 21 days, and 1-, 3-, 6-, and 12-month treatment using the Yale-Brown Obsessive Compulsive Scale and Global Assessment of Functioning (GAF). Compared with the pharmacotherapy and PCBT groups, the severity of OCD symptoms was significantly reduced (P < 0.001), the rates of response (100%) and remission (85.0%) were significantly higher (P < 0.001), and relapse rate was lower (P = 0.017) in PCCT group during the 1-year follow-up. In addition, the GAF score was significantly higher in the PCCT group than in the other two groups (P < 0.001). Our preliminary data suggest that PCCT is a more efficacious psychotherapy for OCD patients than pharmacotherapy or PCBT.

show abstract

Section: Discussionsupporting

confidence: 84%

“…It is known that symptoms of OCD have varied little over time (pathological scrupulosity, for example, has long been documented) or place (similar symptoms are seen across many cultures; Ames et al. ; Lawrence ). Therefore, CCT may be an applicable therapy and is worth exploring in different cultures.…”

Section: Discussionmentioning

confidence: 99%

A promising randomized trial of a new therapy for obsessive–compulsive disorder

Wen

Ma³

et al. 2012

Brain and Behavior

View full text Add to dashboard Cite

show abstract

“…Severe obsessive-compulsive symptoms are less frequently observed in AD patients. The obsessive behavior in Alzheimer disease patients may differ from classical obsessive-compulsive disorder insofar as the subjects are unaware of it while at the same time resisting change [6].…”

Section: Introductionmentioning

confidence: 99%

Fluoxetine in Alzheimer's Disease with Severe Obsessive Compulsive Symptoms and a Low Density of Serotonin Transporter Sites

Marksteiner¹,

Walch²,

Bodner³

et al. 2004

Pharmacopsychiatry

View full text Add to dashboard Cite

The treatment of behavioral disturbances is particularly challenging in patients suffering from dementia. In an 80-year-old female patient with probable AD and severe obsessive and compulsive symptoms, we demonstrated a significant reduction in the density of serotonin transporter sites using 1231-beta-CIT SPECT. Treatment with fluoxetine for 6 months resulted in significant symptom relief and an increasing density of serotonin transporter sites when compared to the beginning of treatment. Therefore, this report provides evidence that fluoxetine is a treatment option for patients with AD and severe obsessive-compulsive symptoms and highlights the importance of the serotoninergic system.

show abstract

Dementia

Whatmough

2010

Handbook of Medical Neuropsychology

View full text Add to dashboard Cite

Is the Finding of Obsessional Behaviour Relevant to the Differental Diagnosis of Vascular Dementia of the Binswanger Type?

Cited by 9 publications

References 41 publications

A promising randomized trial of a new therapy for obsessive–compulsive disorder

A promising randomized trial of a new therapy for obsessive–compulsive disorder

Fluoxetine in Alzheimer's Disease with Severe Obsessive Compulsive Symptoms and a Low Density of Serotonin Transporter Sites

Dementia

Contact Info

Product

Resources

About