Fluoxetine in Alzheimer's Disease with Severe Obsessive Compulsive Symptoms and a Low Density of Serotonin Transporter Sites

Marksteiner, Josef; Walch, T.; Bodner, Tamara; Gurka, P.; Donnemiller, Eveline

doi:10.1055/s-2003-43051

Cited by 20 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only a single case study was reported with SERT imaging using [ 123 I] -CIT in a female patient with probable AD and severe obsessive and compulsive symptoms [609]. A decrease in SERT availability was found.…”

Section: Serotonin Transporter Imaging In Neurological Diseasesmentioning

confidence: 99%

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Brust¹,

Hesse²,

Müller³

et al. 2006

CPSR

View full text Add to dashboard Cite

Nuclear medicine imaging techniques like positron emission tomography (PET) and single-photon emission computed tomography (SPECT) apply radiolabeled drugs that bind selectively to specific neurotransmitter receptors and transporters such as the serotonin transporter (SERT) in the living human brain. They can help overcome certain limitations of postmortem, platelet and genetic studies of the SERT. This review compares the outcome of those studies with recent neuroimaging findings. The first part of this review deals with the choice of radioligands used to quantify SERT distribution in the human brain. The second part summarizes studies performed to understand the normal physiology of the serotonergic system. Selective serotonin reuptake inhibitors (SSRIs), used to treat a wide range of neuropsychiatric disorders with emotional instability and behavioral control deficits, compete with SERT radioligands and have been investigated in pharmacological PET and SPECT studies in healthy volunteers and patients. Part three reviews SERT imaging studies in patients, which have meanwhile been performed in most disorders that benefit from SSRI treatment. It is hypothesized that serotonin deficits and neuropsychiatric symptoms are linked by the inhibition of involuntary emotional reactions to external and internal stimuli. This could explain, why the consistency of many SERT neuroimaging findings is low, and may help develop individual treatment strategies in therapy-nonresponsive cases and to engineer new drugs for the therapy of neuropsychiatric disorders.

show abstract

Section: Serotonin Transporter Imaging In Neurological Diseasesmentioning

confidence: 99%

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Brust¹,

Hesse²,

Müller³

et al. 2006

CPSR

View full text Add to dashboard Cite

show abstract

“…Acute stress activates the hypothalamic-pituitary-adrenal (HPA) axis, as well as monoaminergic neurotransmission in the brain, and affects the expression of numerous genes, including brain-derived neurotrophic factor ( BDNF ) (Pacák and Palkovits, 2001). Dysfunctions of the HPA axis (Phillips et al, 2006; Ströhle and Holsboer, 2003), monoaminergic neurotransmission (Delgado and Moreno, 2000; Graef, 2003; Southwick et al, 1999), GABAergic neurotransmission (Cameron and Nesse, 1988), and abnormal expression of BDNF transcripts (Duman and Monteggia, 2006) have been observed in some stress-related psychiatric disorders. However, it remains to be seen which of these changes are critical causal events mediating the pathophysiological mechanisms underlying stress-related psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

Decreased response to social defeat stress in μ-opioid-receptor knockout mice

Komatsu

Ohara

Sasaki

et al. 2011

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Substantial evidence exists that opioid systems are involved in stress response and that changes in opioid systems in response to stressors affect both reward and analgesia. Reportedly, mice suffering chronic social defeat stress subsequently show aversion to social contact with unfamiliar mice. To further examine the role of opioid systems in stress response, the behavioral and neurochemical effects of chronic social defeat stress (psychosocial stress) were evaluated in μ-opioid-receptor knockout (MOR-KO) mice. Aversion to social contact was induced by chronic social defeat stress in wild-type mice but was reduced in MOR-KO mice. Moreover, basal expression of brain-derived neurotrophic factor (BDNF) mRNA in MOR-KO mice hippocampi was significantly lower than in wild-type mice. Psychosocial stress significantly decreased BDNF mRNA expression in wild-type mice but did not affect BDNF expression in MOR-KO mice; no difference in basal levels of plasma corticosterone was observed. These results suggest that the μ-opioid receptor is involved in the behavioral sequelae of psychosocial stress and consequent regulation of BDNF expression in the hippocampus, and may play an important role in psychiatric disorders for which stress is an important predisposing or precipitating factor, such as depression, posttraumatic stress disorder, and social anxiety disorder.

show abstract

“…An increase in cell apoptosis in the hippocampus attenuates negative feedback inhibition of the hippocampus on the HPA axis, in turn, stimulating the release of more CORT [ 39 ]. On the other hand, a state of depression can make the HPA axis hyperactive, and alleviating clinical symptoms can have a normalizing effect on the HPA axis [ 40 , 41 ]. Thus, restoration of HPA axis activity may be a feasible treatment strategy for depression.…”

Section: Discussionmentioning

confidence: 99%

Stellate ganglion block attenuates chronic stress induced depression in rats

et al. 2017

View full text Add to dashboard Cite

BackgroundStress is a significant factor in the etiology of depression. Stellate ganglion block (SGB) has been shown to maintain the stability of the autonomic system and to affect the neuroendocrine system, including the hypothalamic–pituitary–adrenal (HPA) axis. The objective of this study was to determine the antidepressant-like effects of SGB on the autonomic system and the HPA axis, apoptosis-related proteins, related spatial learning and memory impairment, and sensorimotor dysfunction.MethodsForty-eight Sprague Dawley rats were assigned to four experimental groups: control + saline (sham group), control + SGB (SGB group), unpredictable chronic mild stress (UCMS) + saline (UCMS group), and UCMS + SGB (UCSG group). Stress-induced effects and the function of SGB were assessed using measures of body weight, coat state, sucrose consumption, and behavior in open-field and Y-maze tests. Neuronal damage was assessed histologically using the hematoxylin-eosin (HE) staining method, while western blotting was used to investigate changes in the expression of apoptosis-related proteins. Plasma corticotropin-releasing factor (CRF), adrenocorticotropic hormone (ACTH), corticosterone (CORT), noradrenaline and adrenaline were measured to evaluate changes in the autonomic system and HPA axis.ResultsSGB treatment significantly improved sensorimotor dysfunction and spatial learning and memory impairment following UCMS. Moreover, UCMS significantly decreased body weight, sucrose preference and anti-apoptotic protein Bcl-2, and increased scores on measures of coat state, adrenal gland weight, levels of CORT, CRF, ACTH, noradrenaline and adrenaline, as well as increased neuronal loss, cell shrinkage, nuclear condensation, and the pro-apoptotic protein Bax. These symptoms were attenuated by treatment with SGB.ConclusionsThese findings suggest that SGB can attenuate depression-like behaviors induced by chronic stress. These protective effects appear to be due to an anti-apoptotic mechanism of two stress pathways–the autonomic system and the HPA axis.

show abstract

Fluoxetine in Alzheimer's Disease with Severe Obsessive Compulsive Symptoms and a Low Density of Serotonin Transporter Sites

Cited by 20 publications

References 15 publications

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Neuroimaging of the Serotonin Transporter: Possibilities and Pitfalls

Decreased response to social defeat stress in μ-opioid-receptor knockout mice

Stellate ganglion block attenuates chronic stress induced depression in rats

Contact Info

Product

Resources

About