Is the central corneal thickness of diabetic patients thicker than that of non-diabetics’ eyes?

Mathebula, Solani D.; Segoati, Tshegofatso M.

doi:10.4102/aveh.v74i1.307

Cited by 6 publications

(9 citation statements)

References 25 publications

(39 reference statements)

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“…Our results were concordant with those by other researchers globally, who either showed increased or significantly increased mean CCT in NPDR and PDR compared to control and NDR. 9,12,[14][15][16][17][18][19] Mean CECC observed by us was similar in control and patients with NDR. Significant reduction in CECC compared to control and NDR was also observed in NPDR and PDR.…”

Section: Discussionmentioning

confidence: 52%

Association of Central Corneal Thickness and Central Corneal Endothelial Cell Count With Progressive Stages of Diabetic Retinopathy

Sasmal¹,

Das²,

Singh³

2017

Jebmh

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BACKGROUND Diabetes mellitus along with its different serious pathological complications are increasing very rapidly in both developed and developing countries and manifesting as an escalating pandemic leading to morbidity and untimely death. This may lead to irreversible socioeconomic and psychosocial damage to the individuals, families and communities, either directly or indirectly. Assessment of Central Corneal Thickness (CCT) and Central Corneal Endothelial Cell Count (CCEC) in different stages of DR would help us to understand how rapidly the disease spreads, which could in turn be used as guidelines for disease screening in patients as risk to developing the disease. The aim of the study is to understand the association of CCT and CECC with progressive stages of Diabetic Retinopathy (DR) in Diabetes Mellitus type 2 (DM-2). MATERIALS AND METHODS A case-control study was performed with a random eye from cases, No Diabetic Retinopathy (NDR), Nonproliferative Diabetic Retinopathy (NPDR) and Proliferative Diabetic Retinopathy (PDR) to determine association of DR with CCT and CECC. Parameters were quantified by ultrasonic pachymeter and specular microscope and results statistically analysed to understand significant association. RESULTS Significant increase in CCT was observed in NPDR and PDR compared to controls or NDR. Conversely, NPDR and PDR showed significant decrease compared to controls or NDR. CCT and CECC showed significant inverse correlation in all groups. CONCLUSION CCT and CECC showed significant increase and decrease respectively with stages of DR and were inversely correlated with each other. Assessment of CCT and CECC could thus be used as effective indicators of ocular manifestations of DM for early therapeutic intervention.

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Section: Discussionmentioning

confidence: 52%

Association of Central Corneal Thickness and Central Corneal Endothelial Cell Count With Progressive Stages of Diabetic Retinopathy

Sasmal¹,

Das²,

Singh³

2017

Jebmh

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“…The present study showed that the presence of DR affect CCT measurement. Mathebula and Segoati found no statistically significant difference between CCT in patients with DR and those without DR [25]. Unlike, another study by Parekah et al which reported a thicker CCT in patients with DR compared to controls [13].…”

Section: Discussionmentioning

confidence: 81%

“…Previous studies measured CCT in type I and type II diabetes mellitus (with and without DR) without comparing the values between the two groups [22][23][24][25]. While other studies measured the CCT in one type of diabetes mellitus only [13,21,26].…”

Section: Discussionmentioning

confidence: 99%

Diabetic Retinopathy and Central Corneal Thickness

2019

JOCR

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Background: Diabetes mellitus (DM) is a metabolic disease that can lead to many ocular complications such as increased Central Corneal Thickness (CCT), cataracts, and diabetic retinopathy. The aim of this study was to compare the CCT between subjects with type I and type II diabetes. Method: This was a retrospective study which included subjects with diabetes (with and without Diabetic Retinopathy (DR)) aged between 18 to 80 years old. The data collected were type and duration of diabetes mellitus, diabetes treatment, glycated hemoglobin level, visual acuity, CCT, and intra ocular pressure. Subjects were divided into subgroup (with and without DR). Statistical program (SPSS) was used to compare the central corneal thickness between the groups. Result: A total of 205 subjects with type I (n=100) and type II (n=105) diabetes were included in this study. In type 1 DM, the mean CCT was 547.06±27.3 microns in patients with diabetic retinopathy (DR) and 533.85±26.8 microns in patients without DR. In type 2 DM, the mean CCT was 542.85±39.3 microns in patients with DR and 532.44±27.4 microns in patients without DR. The CCT in type 1 diabetic patients was higher in both groups (with and without DR) than the CCT in type 2 diabetic patients in both groups (with and without DR). However, this was not statistically significant. Conclusion: The type of diabetes mellitus did not affect CCT. The presence of diabetic retinopathy in either type I or type II diabetes mellitus can affect the measurements of CCT.

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“…This review is limited to studies conducted on normal healthy African samples and excludes those that have included individuals with systemic conditions 75 (diabetes mellitus and http://www.avehjournal.org Open Access hypertension) and glaucoma disorders 76,77 , as these factors can influence CCT measurements. 1,48,64,78 In conclusion, this review draws attention to the assumption that CCT measurements in one African population cannot necessarily be extrapolated to other African populations. This implies that there may be other factors, even within the same race group, that contribute to differences in CCT measurements.…”

Section: Discussionmentioning

confidence: 99%

A review of African studies on central corneal thickness

Rampersad

Hansraj

2016

African Vision and Eye Health

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Recently, there has been increasing interest in understanding central corneal thickness (CCT) measurements in various populations. This may be related to the influence of CCT in the diagnosis, classification and management of glaucoma. In addition, CCT measurements are also important for monitoring corneal diseases and contact lens wear, indicating the overall health of the cornea and assessing eligibility for refractive surgery. This article reviews studies that have reported CCT measurements in non-glaucomatous African sub-populations. The CCT measurements, gender associations and limitations of these studies are highlighted. The findings of these studies and their implications are discussed in relation to global studies reporting on CCT measurements.

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Is the central corneal thickness of diabetic patients thicker than that of non-diabetics’ eyes?

Cited by 6 publications

References 25 publications

Association of Central Corneal Thickness and Central Corneal Endothelial Cell Count With Progressive Stages of Diabetic Retinopathy

Association of Central Corneal Thickness and Central Corneal Endothelial Cell Count With Progressive Stages of Diabetic Retinopathy

Diabetic Retinopathy and Central Corneal Thickness

A review of African studies on central corneal thickness

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