A review of African studies on central corneal thickness

Rampersad, Nishanee; Hansraj, Rekha

doi:10.4102/aveh.v75i1.341

Cited by 4 publications

(3 citation statements)

References 68 publications

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“…A thick cornea causes IOP to be overestimated, whereas a thin cornea causes IOP to be underestimated. 20 The results of this study suggest an increase in CCT post-mydriasis and an increase in IOP; however, insignificant in IOP. By extension, there is a close link between the instillation of 1% tropicamide and an increase in CCT; however, the mechanism remains unclear, but it could be postulated to epithelial oedema caused by the instillation of eyedrops.…”

Section: Discussionmentioning

confidence: 47%

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The effect of 1% tropicamide on central corneal thickness and intraocular pressure

Mashala,

Nukeri,

Phaka

et al. 2024

African Vision and Eye Health

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Background: Dilating the eye with tropicamide may alter the intraocular pressure (IOP) because of an obstruction of the iridocorneal angle, resulting in decreased aqueous outflow drainage. Also, the repeated application of eyedrops and instrumentation could lead to increased central corneal thickness (CCT), consequently affecting IOP.Aim: This study aimed to determine the effect of 1% tropicamide on CCT and IOP post-mydriasis among the University of Limpopo optometry students.Setting: The data were collected at the optometry clinic of the University of Limpopo.Methods: A within-subject experimental study was conducted on 59 healthy subjects aged 18 years – 28 years. A computer assisted simple random probability sampling was used to identify a sample of participants from the study population (N = 200). Baseline and post-mydriasis IOP (20 min, 30 min, and 45 min intervals) were measured with a Goldmann applanation tonometer. Central corneal thickness and IOP were analysed using means, correlations and paired t-tests.Results: The mean CCT pre-mydriasis was 504.68 μm, and post-dilation was 507.90 μm, 510.08 μm and 509.25 μm at 20 min, 30 min, and 45 min, P = 026, p = 0.033, P = 0.004, respectively. Moreover, the mean IOP pre-mydriasis was 15.97 mmHg, and post-dilation was 16.85 mmHg, 16.46 mmHg and 16.85 mmHg over 20 min, 30 min, and 45 min of followed-up time, p = 0.140, p = 0.432, and p = 0.183, respectively.Conclusion: Measuring IOP post-dilation is still valid; however, CCT should be measured before the instillation of tropicamide.Contribution: This study analysed the effect of 1% tropicamide on CCT and IOP post-mydriasis in a clinical South African context.

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Section: Discussionmentioning

confidence: 47%

“…19 The broad distribution of CCT ranges from 519 µm to 550 µm in Ethiopians and South Africans, respectively. 20 Goldmann applanation tonometry (GAT) is considered the gold standard against which all other tonometry are compared. 21 The GAT is performed under topical anaesthesia.…”

Section: Introductionmentioning

confidence: 99%

The effect of 1% tropicamide on central corneal thickness and intraocular pressure

Mashala,

Nukeri,

Phaka

et al. 2024

African Vision and Eye Health

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“…However, data on CCT and CECD in normal eyes within SSA are only available for a few countries, precisely Nigeria [12,13], South Africa [4,14], Cameroon [15], Ghana [10,16], Ethiopia [17], and Sudan [18]. A review of these reports suggests wide variations in these parameters within SSA sub-regions [19], further substantiating the establishment of normative values for each population or subpopulation. This view is also supported by consistent observation of thinner corneas in Blacks than other racial groups [4,14,[20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Profile of central corneal thickness and corneal endothelial cell morpho-density in healthy Congolese eyes

2021

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Purpose To determine the pachymetric and corneal endothelial cell morphometric features and their relationship to ocular and systemic factors in healthy Congolese subjects. Methods Non-contact specular microscopy was used in 278 healthy eyes (278 subjects) to measure central corneal thickness (CCT), corneal endothelial cell density (CECD) along with cell size, coefficient of variation (CV) in cell size, and hexagonality (HEX). The lower and upper reference limits and average values for each parameter were determined. Correlation and association of average values with anthropo-demographic and clinical variables were assessed. Results The mean age was 38.9 ± 17.2 years (10.9–80.7 years). Average values were 504.2 ± 30.7 μm (CCT), 2907.1 ± 290.9 cells/mm2 (CECD), 348.5 ± 38.4 μm2 (cell size), 32.9 ± 3.6% (CV), and 51.8 ± 7.2% (HEX). CCT was 504.9 ± 33.6 μm in men and 503.6 ± 28.3 μm in women (p = .73); values for CECD were 2917.1 ± 253.5 cells/mm2 and 2899.2 ± 317.8 cells/mm2 (p = 0.61), respectively. Lower and upper reference limits were 449.6 μm and 566.0 μm for CCT, and 2165.3 cells/mm2 and 3414.4 cells/mm2 for CECD, respectively. CCT correlated with body mass index (BMI), (r = − 0.12, P = 0.04). CECD decreased with age (r = − 0.49, P < 0.001), BMI (r = − 0.20, P = 0.001), intraocular pressure (r = − 0.13, P = 0.029) and ocular perfusion pressure (r = − 0.28, P = 0.028). CECD decayed by 8.3 cells/mm2 or 0.30% per year of age and CCT decreased by 0.72 μm per kg/m2. Conclusions Mean central cornea was thinner, CECD higher, and references limits lower than reported in other African populations. The CCT and CECD normative values reported herein will be useful for both clinical and research purposes in this population.

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Interocular Symmetry and Repeatability of Central Corneal Thickness and Corneal Endothelial Cell Morphology and Density in Healthy Eyes of Congolese

Kelekele

Lubeji

Mwanza

2021

Seminars in Ophthalmology

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A review of African studies on central corneal thickness

Cited by 4 publications

References 68 publications

The effect of 1% tropicamide on central corneal thickness and intraocular pressure

The effect of 1% tropicamide on central corneal thickness and intraocular pressure

Profile of central corneal thickness and corneal endothelial cell morpho-density in healthy Congolese eyes

Interocular Symmetry and Repeatability of Central Corneal Thickness and Corneal Endothelial Cell Morphology and Density in Healthy Eyes of Congolese

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