Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?

Panayi, Demetri; Tekkis, Paris; Fernando, Ruwan; Khullar, Vikram

doi:10.1007/s00192-010-1123-3

Cited by 18 publications

(23 citation statements)

References 12 publications

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“…Complete disclosure of the effect of treatment on BWT requires conduction of additional studies reinforcing outcomes of this study. [16] In conclusion our study data have shown increased BWT in women with OAB both before, and after urination when compared with healthy women. Since measurements using transabdominal US are simple, cheap, and noninvasive which can be applied in outpatient basis, this method should be considered in patients with OAB symptoms.…”

Section: Discussionsupporting

confidence: 55%

Assessment of bladder wall thickness in women with overactive bladder

Üçer

Gümüş

Albaz

et al. 2016

Turkish Journal of Urology

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Objective: To compare bladder wall thickness (BWT) between female patients with overactive bladder (OAB) and aged-matched healthy controls. Material and methods:Thirty-six female patients with OAB and 31 healthy women were enrolled in the present prospective observational study. Qmax and Qave were measured by using uroflowmetry in all of the women in the patient and control groups, and also maximum bladder capacity (MBC), post-void residual urine (PVRU), prevoiding and postvoiding BWT were measured by using transabdominal ultrasound. Lower urinary tract symptoms of the participants were assessed by using Overactive Bladder Version-8 (OAB-V8) and International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). All of the data were statistically compared between the patient and control groups. In the patient group, the relationships between parameters were evaluated correlation analysis. Results:The mean age of the patients and controls were similar (respectively, 45.58±12.35 and 44.21±11.60 years (p= 0.68). The mean pre-and post-voiding BWT, OAB-V8 and ICIQ-SF scores of the patients were significantly higher than the controls. In the patient group, the moderate positive correlations between BWT with Qmax (p= 0.02) and Qave (p= 0.02) were found. Conclusion:This study showed that the BWTs of the female patients with OAB are higher than those of healthy women. Further studies should investigate the changes in BWT of patients with OAB after treatment of OAB.

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Section: Discussionsupporting

confidence: 55%

Assessment of bladder wall thickness in women with overactive bladder

Üçer

Gümüş

Albaz

et al. 2016

Turkish Journal of Urology

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“…Некоторые исследователи показали снижение параметров ТСМП у женщин с ГМП и гипер-трофией детрузора на фоне терапии антимускариновыми препаратами [20,21]. Несмотря на то что получены только предварительные результаты, можно предположить веду-щую роль метода для определения эффективности лече-ния пациенток с ГМП.…”

Section: надлобковый доступunclassified

“…[21] выявлена прямая за-висимость показателя ТСД и степени тяжести ургентно-сти. V. Khullar и соавт.…”

Section: надлобковый доступunclassified

“…Подобные результаты получены в исследовании у 58 женщин с ГМП и гипертрофией детрузора, получавших антимускариновую терапию (дарифенацин, фезотеро-дин, солифенацин, оксибутинин, толтеродин) в течение 12 нед [21]. Исходно среднее значение ТСМП, измерен-ное трансвагинальным доступом, у всех пациенток со-ставило 5,7 мм (5,6-5,9 мм).…”

Section: надлобковый доступunclassified

See 1 more Smart Citation

Diagnostic and prognostic possibilities of ultrasound study in patients with overactive bladder

Amirova¹,

Балан²,

Kovaleva³

et al. 2015

Ross. vestn. akush.-ginekol.

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confidence: 99%

Measuring the effect of antimuscarinics in the bladder

et al. 2011

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Dear Editor, We thank Professor Wiwanitikit for his letter [1] regarding our recent publication [2]. In answer to his queries, we feel that the visual analogue scale (VAS) for urgency is a subjective measure of sensory function as felt by the patient. The motor function was determined using the ultrasound measurement of bladder wall thickness (BWT), on the basis that if there was increased motor activity of the detrusor muscle, as in detrusor overactivity, this would be reflected in hypertrophy, which we proposed would be reversed if antimuscarinics had an effect on motor function.The VAS for urgency was used to determine the changes in the cardinal symptom of urgency associated with detrusor overactivity. We acknowledge we cannot prove the direct relationship to bladder sensory processes. In this study we are attempting to determine whether the sensation of urgency and its improvement, as reported by the patient, corresponds to any changes in motor function as measured by BWT. The observation of continued lessening of sensation of urgency after the BWT had stopped declining led to the conclusion that the amelioration of urgency is not wholly explained by the reversing of the hypertrophy seen in detrusor overactivity. It is on this basis that we concluded that the mechanism by which antimuscarinics improve patients' symptoms is more complex than simply inhibiting detrusor contractions and may involve a sensory effect. We do acknowledge that we have not provided evidence of this interrelationship other than these observations. The PPBC score was used to provide additional information as to improvement of overall bladder condition rather than being directly related to changes in motor or sensory processes. We believe it is important to use subjective measures of improvement when analyzing the effect of any treatment as these subjective measures form the basis of assessing the impact of a condition as well as the effect.

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Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?

Abstract: The mechanism of action of antimuscarinics appears to be a complex interaction of sensory and motor components.

Cited by 18 publications

References 12 publications

Assessment of bladder wall thickness in women with overactive bladder

Assessment of bladder wall thickness in women with overactive bladder

Diagnostic and prognostic possibilities of ultrasound study in patients with overactive bladder

Measuring the effect of antimuscarinics in the bladder

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