Is single-dose prophylactic gentamicin associated with acute kidney injury in patients undergoing cardiac surgery? A matched-pair analysis

Nielsen, Dorthe Viemose; Fedosova, Maria; Hjortdal, Vibeke E.; Jakobsen, Carl-Johan

doi:10.1016/j.jtcvs.2014.05.090

Cited by 24 publications

(20 citation statements)

References 26 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thirty‐six studies were included in the final synthesis: one thesis and 35 journal articles . The 36 studies included 11 randomized controlled studies (two crossover designs), 18 cohort studies, one retrospective survey, three pharmacokinetic and three quasiexperimental studies.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Adverse effects of a single dose of gentamicin in adults: a systematic review

Hayward¹,

Harding²,

Molloy³

et al. 2017

Brit J Clinical Pharma

View full text Add to dashboard Cite

RESULTSIn total, 15 522 records were identified. After removal of duplicates, screening of title/abstracts for relevance and independent selection of full texts by two reviewers, 36 studies were included. Across all the included studies, 24 107 participants received a single one-off dose of gentamicin (doses ranged from 1 mg kg -1 to 480 mg per dose). Acute kidney injury was described in 2520 participants receiving gentamicin. The large majority of cases were reversible. There were no cases of ototoxicity reported in patients receiving gentamicin. A meta-analysis was not performed due to study heterogeneity. CONCLUSIONSA significant number of patients saw a transient rise in creatinine after a single dose of gentamicin at doses up to 480 mg. Persistent renal impairment and other adverse events were relatively rare.British Journal of Clinical Pharmacology Br J Clin Pharmacol (2018) 84 223-238 223

show abstract

Section: Resultsmentioning

confidence: 99%

“…Reported adverse events are summarized in Table . Twenty‐three , of the 36 included studies, reported adverse events in the gentamicin arm of their study although not all adverse events were related to gentamicin. Pons et al .…”

Section: Resultsmentioning

confidence: 99%

Adverse effects of a single dose of gentamicin in adults: a systematic review

Hayward¹,

Harding²,

Molloy³

et al. 2017

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…Niesel et al, also noted AKI with rise in serum creatinine in 22% cases after receiving single prophylactic dose of gentamycin [12].…”

Section: Resultsmentioning

confidence: 93%

Risk of Acute Kidney Injury with Amikacin versus Gentamycin both in Combination with Metronidazole for Surgical Prophylaxis

Giri

Bajracharya

et al. 2016

JCDR

View full text Add to dashboard Cite

“…We also assessed the incidence of AKI with the Acute Kidney Injury Network and the KDIGO definitions, and we did not identify any new case of AKI using these definitions. Finally, we chose to include patients who received at least 5 days of AG since when we designed the study, there were no published data on the possible nephrotoxicity associated with a single dose of AG [10,49]. We do not know whether our results apply to patients receiving empiric AG treatment for a few days until culture results become available.…”

Section: Discussionmentioning

confidence: 99%

Acute Kidney Injury and Renal Recovery with the Use of Aminoglycosides: A Large Retrospective Study

Paquette

Bernier-Jean

Brunette³

et al. 2015

Nephron

View full text Add to dashboard Cite

Background: Recent acute kidney injury (AKI) guidelines, based on studies performed a decade ago, recommend avoiding aminoglycosides (AGs) in patients at risk of AKI. Whether present patient characteristics and management have changed this risk is uncertain. We determined the current incidence, risk factors and outcomes of AG-AKI. Methods: We retrospectively identified adult patients who received gentamicin or tobramycin for ≥5 days in 2 large university-affiliated centers, excluding critically ill and dialysis patients. We assessed the incidence of Risk, Injury, Failure, Loss and End-stage kidney disease criteria of AKI risk and then matched each AKI to 2 controls of same age and gender to determine factors associated with AG-AKI and its recovery, defined by a creatinine within 150% of baseline by 21 days. Results: Since 2001, the frequency of AG administration and dosing declined, but the incidence of AG-AKI remained constant. Of the 562 patients who received AG for ≥5 days, 65 (12%) developed AG-AKI after 11 (IQR 8-15) days, with 56, 29 and 15% having stages 1, 2 and 3 AKI, respectively. We matched these to 130 controls. In this nested case-control study, independent AKI risk factors were vancomycin coadministration, high AG trough levels and heart failure. AG-AKI compared to AG exposure without AKI was associated with greater mortality. Renal recovery occurred in 51% of the AKI patients and was less likely with heart failure and higher AKI severity. Conclusion: AG administration has recently decreased but the risk of AKI remained unchanged and half of the patients did not recover. Vancomycin coadministration, high AG trough levels and heart failure independently predicted AKI.

show abstract

Is single-dose prophylactic gentamicin associated with acute kidney injury in patients undergoing cardiac surgery? A matched-pair analysis

Cited by 24 publications

References 26 publications

Adverse effects of a single dose of gentamicin in adults: a systematic review

Adverse effects of a single dose of gentamicin in adults: a systematic review

Risk of Acute Kidney Injury with Amikacin versus Gentamycin both in Combination with Metronidazole for Surgical Prophylaxis

Acute Kidney Injury and Renal Recovery with the Use of Aminoglycosides: A Large Retrospective Study

Contact Info

Product

Resources

About