Risk of Acute Kidney Injury with Amikacin versus Gentamycin both in Combination with Metronidazole for Surgical Prophylaxis

Giri, Vishal Prakash; Giri, Om Prakash; Bajracharya, Subarna; Khan, Farhan; Sinha, Shanker Prasad; Kanodia, Shubhra; Bansal, Chitrak

doi:10.7860/jcdr/2016/15621.7099

Cited by 8 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirty‐six studies were included in the final synthesis: one thesis and 35 journal articles . The 36 studies included 11 randomized controlled studies (two crossover designs), 18 cohort studies, one retrospective survey, three pharmacokinetic and three quasiexperimental studies.…”

Section: Resultsmentioning

confidence: 99%

“…Reported adverse events are summarized in Table . Twenty‐three , of the 36 included studies, reported adverse events in the gentamicin arm of their study although not all adverse events were related to gentamicin. Pons et al .…”

Section: Resultsmentioning

confidence: 99%

“…A significant number of studies have been published in the last 3 years, almost as many as in the previous 50 years. The majority of these recent studies are a form of cohort study, without randomization.…”

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies reported nephrotoxicity following gentamicin. A definition of nephrotoxicity or AKI was often absent or varied between studies (Figure ).…”

Section: Resultsmentioning

confidence: 99%

“…Giri et al . was one of only two randomized studies published in the last 16 years. AKI, defined as a sudden (within 48 h) decrease in renal function using Acute Kidney Injury Network Staging , was reported in both groups.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Adverse effects of a single dose of gentamicin in adults: a systematic review

Hayward¹,

Harding²,

Molloy³

et al. 2017

Brit J Clinical Pharma

View full text Add to dashboard Cite

RESULTSIn total, 15 522 records were identified. After removal of duplicates, screening of title/abstracts for relevance and independent selection of full texts by two reviewers, 36 studies were included. Across all the included studies, 24 107 participants received a single one-off dose of gentamicin (doses ranged from 1 mg kg -1 to 480 mg per dose). Acute kidney injury was described in 2520 participants receiving gentamicin. The large majority of cases were reversible. There were no cases of ototoxicity reported in patients receiving gentamicin. A meta-analysis was not performed due to study heterogeneity. CONCLUSIONSA significant number of patients saw a transient rise in creatinine after a single dose of gentamicin at doses up to 480 mg. Persistent renal impairment and other adverse events were relatively rare.British Journal of Clinical Pharmacology Br J Clin Pharmacol (2018) 84 223-238 223

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Seventeen studies reported nephrotoxicity following gentamicin. A definition of nephrotoxicity or AKI was often absent or varied between studies (Figure ).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Adverse effects of a single dose of gentamicin in adults: a systematic review

Hayward¹,

Harding²,

Molloy³

et al. 2017

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

Antibacterial Prophylaxis for Surgical Site Infection in the Elderly: Practical Application

2017

View full text Add to dashboard Cite

Surgical site infections are among the most common healthcare-associated infections and are linked with increased length of hospitalization, re-admission, mortality and significant financial burden. Risk factors for the occurrence of surgical site infections include variables related to the surgical procedure as well as host factors. Increasing age is associated with the occurrence of surgical site infections. The aim of this review is to give an update on the antibiotic prophylaxis for surgical site infection in elderly people. We focused on specific issues and practical applications, such as the importance of targeting the antimicrobial agent to the susceptibility pattern of colonizing flora in selected cases and the need for dosage modifications.

show abstract