“…Seminal ultrastuctural and light microscopy reports in the 1950s and 1960s revolutionized our views of cross‐striated muscles (Hanson and Huxley, ; Huxley and Hanson, ; Huxley and Niedergerke, ; Huxley, ). Kepner () asks in his review whether the arrangements of thick and thin filaments in the sarcomere are optimal in their hexagonal pattern in cross‐section considering the key factors of lattice geometry, ratio of thin and thick filaments, and their arrangements.…”