Is rosacea a systemic disease?

Wollina, Uwe

doi:10.1016/j.clindermatol.2019.07.032

Cited by 34 publications

(54 citation statements)

References 43 publications

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“…Rosacea has been associated with a series of cardiovascular diseases, gastrointestinal disorders, neurologic disorders, and psychiatric disorders [12,76,77]. Wollina noted that rosacea was associated with metabolic, psychiatric, and neurologic disorders and specific types of cancer, and Wollina suggested that rosacea should be considered a systemic disease [78].…”

Section: Systemic Comorbiditiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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Rosacea is a chronic and inflammatory skin disease characterized by flushing, nontransient erythema, papules/pustules, telangiectasia, and phymatous changes. Secondary manifestations, such as itching, burning, or stinging, are often observed in patients with rosacea. In 2017, a phenotype-based approach for diagnosis and classification was recommended. With the update of the diagnosis and classification of rosacea, treatment options for patients with rosacea have attracted the attention of dermatologists. Here, we summarize the latest advances in rosacea treatment, including skin care and cosmetic treatments, topical therapies, oral therapies, laser- and light-based therapies, injection therapies, treatments for specific types of rosacea, treatments for systemic comorbidities, and combination therapies. The impact of the phenotype-based approach on rosacea treatment and future directions are also discussed.

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Section: Systemic Comorbiditiesmentioning

confidence: 99%

Rosacea Treatment: Review and Update

Zhang

Tang

Wang

et al. 2020

Dermatol Ther (Heidelb)

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“…These unpleasant symptoms may lead to physical discomfort (e.g. burning and stinging) and cause psychological distress [7,8]. Multiple comorbidities have been found to be associated with rosacea [9], including cardiovascular disease [10], gastrointestinal disorders [11], neurologic disorders [12], autoimmune condition [13], malignancies [14] and psychiatric disorders [15].…”

Section: Introductionmentioning

confidence: 99%

Depression and Anxiety in Rosacea Patients: A Systematic Review and Meta-Analysis

Dai

Lin

Zhang

et al. 2021

Dermatol Ther (Heidelb)

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Introduction: Depression and anxiety are common among people with rosacea. However, the exact magnitude of the prevalence rate and odds ratios (ORs) for depression and anxiety, respectively, in rosacea patients is unclear, and no systematic review or meta-analysis of published data has yet been performed. We therefore performed as systematic review and metaanalysis to determine the prevalence rates and ORs for depression and anxiety in rosacea patients.Methods: We performed a systematic search of the PubMed, Embase and Medline databases for all observational studies published up to October 2020 that reported the prevalence rates and ORs for depression and anxiety in patients with rosacea. The primary outcome measures were prevalence rates and ORs for depression and anxiety in patients with rosacea. Heterogeneity across studies was assessed with the I 2 statistic. Sources of heterogeneity were explored through subgroup and meta-regression analyses. Results: A total of 14 studies involving 14,134,021 patients with rosacea were included in the systematic review and meta-analysis. The pooled prevalence of depression was 19.6% (95% confidence interval [CI] 15.0-24.3%) and that of anxiety was 15.6% (95% CI 11.8-19.3%). The prevalence of depression and anxiety was significantly lower in studies using clinical criteria to diagnose depression and anxiety (9.2 and 10.2%, respectively) than in those studies using screening tools (26.2% [P \ 0.01] and 22.7% [P = 0.03], respectively). The methodological quality of the included studies greatly contributed to the heterogeneity. Patients with rosacea were more likely to experience depression (OR 2.21, 95% CI 1.79-2.72) and anxiety (OR 2.31, 95% CI 1.56-3.44) than healthy controls. Conclusions: This systematic review and metaanalysis indicates that patients with rosacea are at a higher risk of experiencing depression and anxiety. More efforts are warranted to recognize R. Dai and BJ. Lin contributed equally to this study.

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“…However, in a Danish study conducted among 4948 rosacea patients, the results did not support the association of rosacea with cardiovascular disease 13 . Wollina suggested that variations in ethnicities, nutritional status, and other factors may cause the variety of results from different countries 14 …”

Section: Discussionmentioning

confidence: 94%

Evaluation of epicardial fat thickness and the ankle‐brachial index in patients with rosacea: A case‐control study

Çerman¹,

Kara

Karabay

et al. 2021

J of Cosmetic Dermatology

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Background Recent data suggest that rosacea is related to cardiovascular diseases (CVD) due to its inflammatory nature and immune dysregulation. Aim The aim of this study was to evaluate the values of epicardial fat thickness (EFT) and the ankle‐brachial index (ABI) in patients with rosacea, as indicators of subclinical atherosclerosis and CVD risk. Methods This prospective case‐control study was carried out on 62 participants, including 31 rosacea patients and 31 controls. The values of EFT and ABI were measured in all subjects. Results The mean thickness of EFT was statistically higher in rosacea patients (0.54 ± 0.12 mm) than in the controls (0.39 ± 0.05 mm) (P < 0.01). ABI was not significantly different between the subjects with rosacea and the comparison group (1.02 ± 0.1 vs 0.98 ± 0.07; P = 0.131). A total of 29% of the rosacea patients had mitral valve insufficiency (MVI), while 3.2% of the control group had MVI (P = 0.006). A mild degree of tricuspid valve insufficiency (TVI) was present in 45.2% of the rosacea patients, while 19.4% of the controls had TVI (P = 0.03). Conclusion Rosacea may be associated with subclinical cardiac dysfunction. EFT measurements in rosacea patients can provide early detection of possible subclinical cardiovascular diseases, which can be life‐extending in rosacea. However, further studies with larger sample sizes are required to confirm the present findings.

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Is rosacea a systemic disease?

Cited by 34 publications

References 43 publications

Rosacea Treatment: Review and Update

Rosacea Treatment: Review and Update

Depression and Anxiety in Rosacea Patients: A Systematic Review and Meta-Analysis

Evaluation of epicardial fat thickness and the ankle‐brachial index in patients with rosacea: A case‐control study

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