Is resveratrol therapeutic when used to treat allergic rhinitis in rats?

Abstract

TurkeyIs resveratrol therapeutic when used to treat allergic rhinitisinitis in rats?Abstract Purpose: Resveratrol has anti-infective, anti-inflammatory and antioxidant activities. The purpose of this study was to determine the effect of resveratrol in a rat experimental model of allergic rhinitis (AR).Methods: Wistar albino rats were divided into three groups: control (n=7), AR with no treatment (AR+NoTr, n=7) and AR with resveratrol treatment (AR+Res, n=7). For AR+Res, AR was induced and resveratrol given on days 21-28. On day 28, the total blood IgE levels were measured. Allergic symptoms (sneezing, nose-rubbing, eye lacrimation and nasal congestion) were scored on a 0-3 point scale, and histopathological changes in the nasal mucosa were evaluated.Results: Allergic symptom score of AR+NoTr was higher than the other two groups and the score of AR+Res was higher than the control group. Histopathologically, neither ciliary loss nor chondrocyte hypertrophy differed among the three groups; however, vascular congestion, inflammatory and plasma cell numbers, eosinophil and mast cell infiltration and goblet cell numbers were higher and mast cell infiltration was more prominent in AR+NoTr than in AR+Res and control. AR+Res and control did not differ significantly in any histological parameter.In AR+NoTr, nasal mucosa exhibited ciliary loss, squamous epithelial metaplasia, inflammatory cell infiltration, vascular congestion of the lamina propria and goblet cell epithelial metaplasia. In AR+Res, goblet cell metaplasia was focal or absent and infiltration of the lamina propria by inflammatory cells, eosinophils, and plasma cells was reduced relative to AR+NoTr.Conclusion: Allergic symptoms and tissue reactions were reduced by resveratrol treatment in rats with experimentally-induced AR.

A New Experimental Allergic Rhinitis Model in Mice

“…In another rabbit model of AR, AR was induced by IP administration of OVA on days 0, 2, 4 and 6, followed by its intranasal application for seven days (13) . In the literature, AR models have been described in rats induced by a total of 7 IP injections of OVA once a day on days 1, 3, 5, 7, 9, 11 and 13, followed by its once daily intranasal applications for 14 days (6,(14)(15)(16) .…”

Can curcumin modulate allergic rhinitis in rats?

“…All rats except for controls were sensitised with an intraperitoneal injection of ovalbumin (100 µg/animal) and aluminium hydroxide (5 mg/animal) in 0.9 per cent (weight per volume) saline on days 1, 3, 5, 7, 9, 11 and 13 (a total of seven injections). From day 14 onward, animals underwent daily topical intranasal instillation with 50 µl of 2 per cent ovalbumin in saline (weight per volume) for 14 days (25 µl into each nostril) 7 10 …”

In vitro characterization of physico-chemical properties, cytotoxicity, bioactivity of urea-crosslinked hyaluronic acid and sodium ascorbyl phosphate nasal powder formulation

“…However, their long-term use may have side effects (Campbell, 2018;Fokkens et al, 2012;Licari et al, 2017a). To limit these complications and drug resistant refractory phenomena, adjunctive therapeutic agents with antiinflammatory, antioxidant and wound healing activity -like resveratrol, alpha-tocopherol (vitamin E), curcumin, N-acetyl-L-cysteine, bromelain, quercetin, beta-carotene (provitamin A), vitamin C (ascorbic acid) and hyaluronic acid (HA)-are currently being investigated for their ability to restore and maintain nasal mucosal health and functions (Albano et al, 2016;Baumeister et al, 2009;Bozdemir et al, 2016;Casale et al, 2014Casale et al, , 2016Cassandro et al, 2015;Chauhan et al, 2016;Ciofalo et al, 2017;Emiroglu et al, 2017;Helms and Miller, 2006;Hong et al, 2016;Horváth et al, 2016;Podoshin et al, 1991;Sagit et al, 2011;Testa et al, 2017). The present study focused on vitamin C and HA derivatives.…”