Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?

Tekın, Yeşim Bayoğlu; Güven, Süleyman; Kırbaş, Aynur; Kalkan, Yıldıray; Tümkaya, Levent; Güven, Emine Seda Güvendağ

doi:10.1016/j.ejogrb.2014.10.041

Cited by 44 publications

(26 citation statements)

References 26 publications

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“…In continuation to the positive reported effect of resveratrol on endometriosis [101], similar encouraging results of reduction in endometrial lesions size, cell proliferation, vascularization, inflammation, OS and lipid peroxidation markers were recently reported in several animal studies [102][103][104][105][106].…”

Section: Resveratrolmentioning

confidence: 51%

“…Resveratrol Bayoglu Tekin Y et al [105] Animal study Reduction of endometriotic lesion volume, histopathological grade, immunoreactivity to mmp2, mmp9 and VEGF, plasma and PF levels of IL-6, IL-8 and TNF-a Down-regulation of pro-inflammatory cytokines induction of apoptosis and promotion of cellular proliferation and differentiation, decrease in mmp2 and mmp9 activities, suppressed microvessel activity Bruner-Tran KL et al [101] In vitro + In vivo Reduction of number of endometrial implants, total volume of lesions (in vivo) and concentration-dependent reduction of invasiveness in human endometrial stromal cells (in vitro)…”

Section: Decreased Ros Activitymentioning

confidence: 99%

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Targeting oxidative stress to treat endometriosis

Harlev

Gupta

Agarwal

2015

Expert Opinion on Therapeutic Targets

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Section: Resveratrolmentioning

confidence: 51%

Section: Decreased Ros Activitymentioning

confidence: 99%

Targeting oxidative stress to treat endometriosis

Harlev

Gupta

Agarwal

2015

Expert Opinion on Therapeutic Targets

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“…Therefore, pharmacological treatments for endometriosis maintain a hypoestrogenic environment and relieve pelvic pain, but the side effects of these therapies limit their long-term use. Natural therapies were used recently for the treatment of various inflammatory diseases, and these therapies may be an effective treatment strategy for endometriosis [33,34]. …”

Section: Discussionmentioning

confidence: 99%

Euterpe oleracea Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis

et al. 2016

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This study investigated the therapeutic potential of Euterpe oleracea extract (açaí) on the growth and survival of endometriotic lesions using an experimental model. Twenty female Sprague-Dawley rats were randomized into two groups after the implantation and establishment of autologous endometrium onto the peritoneum abdominal wall and treated with 200 mg/kg hydroalcoholic solution extract from açaí stone or vehicle via gastric tube for 30 consecutive days. Body weight, lesion surface areas, histological and immunohistochemistry analyses of vascular endothelial growth factor (VEGF), VEGF receptor-2 (VEGFR-2), metalloproteinase-9 (MMP-9), cyclooxygenase-2 (COX-2) and F4-80 were performed. Levels of VEGF, VEGFR-2, MMP-9 and COX-2 mRNA were measured. Flow cytometry of F4-80 was performed, and ELISA immunoassays measured prostaglandin E2 (PGE2), VEGF and nitric oxide (NO) and concentrations. Macrophage cell line J774.G8 was treated with 10, 20, and 40 μg/mL of açaí for 24, 48 and 72 h, and cell viability was measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assays. Açaí treatment significantly decreased the implant size, and histological examination indicated atrophy and regression. A reduction in immunostaining and mRNA expression of VEGF, MMP-9 and COX-2 was observed, and F4-80 was lower in the treated group than the control group. The treated group also exhibited lower concentrations of PGE2, VEGF and NO compared to the control group. Macrophages cells treated with 20 and 40 μg/ml of açaí reduced cell viability in about 50% after 24, 48 and 72 h. Our results suggest that açaí effectively suppressed the establishment and growth of endometriotic lesions, and this agent is a promising novel pharmacological therapeutic treatment for endometriosis.

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“…In both studies, performed on mouse models, resveratrol significantly reduced the number and volume of the endometriotic lesions, through a reduction in cell proliferation, vascular density, and favoring apoptosis. In addition, another experimental study compared the effects of resveratrol alone and in combination with leuprolide acetate, a gonadotropin-releasing hormone analog 85. The authors found that resveratrol was as effective as leuprolide acetate in endometriosis management when used alone; on the other hand, the combination of resveratrol and leuprolide acetate did not show any beneficial additive effect.…”

Section: Complementary and Alternative Medicinementioning

confidence: 99%

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

Buggio¹,

Barbara²,

Facchin³

et al. 2017

IJWH

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Endometriosis has a multifactorial etiology. The onset and progression of the disease are believed to be related to different pathogenic mechanisms. Among them, the environment and lifestyle may play significant roles. Diet, dietary supplements, physical exercise, osteopathy, massage, acupuncture, transcutaneous electrical nerve stimulation, and Chinese herbal medicine may represent a complementary and feasible approach in the treatment of symptoms related to the disease. In this narrative review, we aimed to examine the most updated evidence on these alternative approaches implicated in the self-management of the disease. In addition, several studies have demonstrated that endometriosis may negatively impact mental health and quality of life, suggesting that affected women may have an increased risk of developing psychological suffering as well as sexual problems due to the presence of pain. In light of these findings, we discuss the importance of integrating psychological interventions (including psychotherapy) and sexual therapy in endometriosis treatment.

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Is resveratrol a potential substitute for leuprolide acetate in experimental endometriosis?

Cited by 44 publications

References 26 publications

Targeting oxidative stress to treat endometriosis

Targeting oxidative stress to treat endometriosis

Euterpe oleracea Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis

Self-management and psychological-sexological interventions in patients with endometriosis: strategies, outcomes, and integration into clinical care

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