Euterpe oleracea Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis

Machado, Daniel Escorsim; Rodrigues-Baptista, Karina Cristina; Alessandra-Perini, Jéssica; Moura, Roberto Soares de; Santos, Thiago Alves dos; Pereira, Kariny Gomes; Silva, Yasmin Marinho Da; Souza, Pergentino José Cunha; Nasciutti, Luiz Eurico; Perini, Jamila Alessandra

doi:10.1371/journal.pone.0166059

Cited by 40 publications

(31 citation statements)

References 68 publications

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“…Also, PGE2 has been reported to induce VEGF expressions thereby contributing to angiogenesis in endometriosis [ 11 60 61 ]. The results observed were in line with earlier reports [ 34 54 62 ] suggesting the significance of the microenvironment of inflammatory mediators and angiogenic factors in progression of endometriosis. Inhibition of inflammatory responses via down-regulating NF-κB signalling and angiogenesis are critical in therapy of endometriosis.…”

Section: Discussionsupporting

confidence: 92%

6-Shogaol reduces progression of experimental endometriosisin vivoandin vitro viaregulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

Wang

Jiang

Yang

et al. 2018

Korean J Physiol Pharmacol

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Endometriosis (EM) is one of the most common gynaecological disorder affecting women in their reproductive age. Mechanisms involved in the pathogenesis of EM remains poorly understood, however inflammatory responses have been reported to be significantly involved. The efficacy of 6-shogaol on proliferation of endometriotic lesions and inflammatory pathways in experimentally-induced EM model was explored in this study. EM was stimulated in Sprague-Dawley rats by implantation of autologous endometrium onto the peritoneum abdominal wall. Separate groups were treated with 6-shogaol (50, 100 or 150 mg/kg b.wt/day) via oral gavage for one month period. Gestrinone (GTN) group received GTN (0.5 mg/kg/day) as positive control. Five weeks after implantation, the spherical volume of ecto-uterine tissues was determined. Treatment with 6-shogaol significantly reduced the implant size. Histological analysis reported atrophy and regression of the lesions. 6-shogaol administration effectively down-regulated NF-κB signaling, VEGF and VEGFR-2 (Flk-1) expression in the endometriotic lesions. Excess production of IL-1β and IL-6 (pro-inflammatory cytokines), PGE2 and nitric oxide (NO) were reduced. Overall, the results of the study reveal the efficacy of 6-shogaol against endometriosis via effectively suppressing proliferation of the lesions and modulating angiogenesis and COX-2/NF-κB-mediated inflammatory cascades.

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Section: Discussionsupporting

confidence: 92%

6-Shogaol reduces progression of experimental endometriosisin vivoandin vitro viaregulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

Wang

Jiang

Yang

et al. 2018

Korean J Physiol Pharmacol

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“…The plant specimen was deposited in the same herbarium with the voucher specimen MG 205222 number. The hydroalcoholic solution extracted from açaí stones was prepared as previously described [ 22 , 24 , 27 , 28 ]. In summary, 200 g of açaí stone were boiled in 400 mL of distilled water for 10 min and mixed for 2 min.…”

Section: Methodsmentioning

confidence: 99%

“…Euterpe oleracea Mart. (Arecaceae), commonly known as “açaí”, is a palm fruit native from the Amazon region of Brazil [ 19 ] whose antioxidant, antinociceptive, anti-inflammatory, and anticancer activities have been previously reported as “natural” therapeutic options in the treatment of several pathologic conditions [ 20 - 28 ]. In fact, recent data from Silva and colleagues showed that açaí extract exerts an antitumorigenic effect in breast cancer malignant cells by inducing an increase in the autophagy process, in addition to decreasing the cellular viability of MCF-7 cells [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

“…In fact, recent data from Silva and colleagues showed that açaí extract exerts an antitumorigenic effect in breast cancer malignant cells by inducing an increase in the autophagy process, in addition to decreasing the cellular viability of MCF-7 cells [ 26 ]. In addition, our group previously demonstrated that açaí plays a remarkable antiangiogenic and anti-inflammatory role in endometriosis, which is a benign disease that presents a largely known malignant behavior [ 28 ]. Furthermore, Ribeiro et al [ 29 ] demonstrated that the genotoxic effects of doxorubicin treatment was attenuated by the acute and subacute açaí treatment in mice due to a decrease in the cardiotoxicity promoted by doxorubicin chemotherapeutic agent.…”

Section: Introductionmentioning

confidence: 99%

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Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer

Alessandra-Perini

Perini

Rodrigues-Baptista

et al. 2018

BMC Complement Altern Med

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BackgroundAmong the processes involved in the breast tumor microenvironment, angiogenesis and inflammation play a central role, and the main factors of these processes are the vascular endothelial growth factor (VEGF), cyclooxygenase 2 (COX-2) and macrophages. Recently, the extract of Euterpe oleracea (açaí), a fruit that is widely found in the Amazon region, already showed antitumorigenic effects in vitro in human breast cancer cell lines. The present study aimed to investigate the effect of açaí on breast cancer using a chemically DMBA (7,12-dimethylbenzanthracene) experimental model.MethodsOne day after initiation of treatment with açaí, mammary carcinogenesis was induced in female Wistar rats using a subcutaneous injection of 25 mg/kg of DMBA in the mammary gland. Forty rats were randomized into two groups: treated with 200 mg/kg of either açaí extract or vehicle, via gastric tube for 16 consecutive weeks. After treatment, the tumor was collected for macroscopic, histological and immunohistochemical (VEGF, vascular endothelial growth factor receptor 2 -VEGFR-2, COX-2 and matrix metalloproteinase -MMP-9) analyses; peritoneal fluid was subjected to flow cytometry (F4–80/MAC-2+) and ELISA immunoassay (VEGF, prostaglandin E2 -PGE2 and interleukin-10 -IL-10). Heart, liver and kidney samples were collected for histological analysis.ResultsAfter 16 weeks of induction, the mammary carcinoma was confirmed by macroscopic and histological evaluation. Survival analysis indicates that açaí increased the survival (P = .0002, long-rank test) and reduced the deaths number (P = .0036, Chi-square test). Açaí treatment decreased the number of inflammatory cells and macrophage positive cells (Mac-2 + F4–80+), as well as promoting a reduction in immunostaining of VEGF, VEGFR-2 and COX-2. The açaí group also exhibited lower concentrations of PGE2, VEGF and IL-10 compared to the control. The histopathological results of the liver and kidneys showed protective effect of açaí, since in the control group, there was an increase in fibrosis, atypical cells and hemorrhagic microenvironment.ConclusionThe results of this study demonstrated the antiangiogenic and anti-inflammatory potential of açaí, like due to the decreases of the number of activated macrophages, resulting in the inhibition of DMBA carcinogenicity in breast cancer.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2183-z) contains supplementary material, which is available to authorized users.

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“…Angiogenesis process-In endometriosis, the central role in pathophysiological mechanisms is attributed to macrophages. These cells increase the intranuclear expression of vascular endothelial growth factor (VEGF) and cyclooxigenase 2 (COX-2) genes, leading to increased angiogenesis and an inflammatory environment[58].…”

mentioning

confidence: 99%

Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Anastasiu

Moga

Neculau

et al. 2020

IJMS

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Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomarkers for endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing the results of these studies in the search of promising perspectives on early diagnosis. Methods: We selected the papers from Google Academic, PubMed, and CrossRef and reviewed recent articles from the literature, aiming to evaluate the effectiveness of various putative serum and urinary biomarkers for endometriosis. Results: The majority of studies focused on a panel of biomarkers, rather than a single biomarker and were unable to identify a single biomolecule or a panel of biomarkers with sufficient specificity and sensitivity in endometriosis. Conclusion: Noninvasive biomarkers, proteomics, genomics, and miRNA microarray may aid the diagnosis, but further research on larger datasets along with a better understanding of the pathophysiologic mechanisms are needed.

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Euterpe oleracea Extract (Açaí) Is a Promising Novel Pharmacological Therapeutic Treatment for Experimental Endometriosis

Cited by 40 publications

References 68 publications

6-Shogaol reduces progression of experimental endometriosisin vivoandin vitro viaregulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

6-Shogaol reduces progression of experimental endometriosisin vivoandin vitro viaregulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses

Euterpe oleracea extract inhibits tumorigenesis effect of the chemical carcinogen DMBA in breast experimental cancer

Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

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