Is Pseudophakia a Risk Factor for Neovascular Age-Related Macular Degeneration?

Sutter, Florian; Menghini, Moreno; Barthelmes, Daniel; Fleischhauer, Johannes; Kurz–Levin, M.; Bosch, Martina M.; Helbig, Horst

doi:10.1167/iovs.06-0766

Cited by 51 publications

(30 citation statements)

References 22 publications

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“…Similar numbers of increased incidences of early or late AMD from 5 to 15 years after cataract surgery were published in other large epidemiological studies [29,30,31], except one [28]; Wang et al [27] reported an OR of 5.7–7.3 for late AMD incidence in pseudophakic patients after 5 years.…”

Section: Discussionsupporting

confidence: 76%

“…Similarly, an increased longtime risk of AMD or AMD progression was found for pseudophakic patients in several large epidemiological trials following patients for 5–15 years after cataract surgery [25,26,27,28,29,30,31,32,33]. Concerning quantitative AMD changes after cataract surgery, no large or prospective studies have been published so far.…”

Section: Introductionmentioning

confidence: 93%

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Monitoring of Drusen and Geographic Atrophy Area Size after Cataract Surgery Using the MD3RI Tool for Computer-Aided Contour Drawing

Brunner

Mora²,

Fonseca³

et al. 2012

Ophthalmologica

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Background/Aims: To monitor possible changes in the cumulated drusen or geographic atrophy area size (CDGAS) of nonexudative age-related macular degeneration (AMD) in patients before and after cataract surgery, using a new tool for computer-aided image quantification. Methods: Randomized, prospective, clinical trial. 54 patients with cataract and nonexudative AMD were randomly assigned into an early surgery group (ES = 28) and a control group (CO = 26) with a 6-month delay of surgery. CDGAS was determined with the MD3RI tool for contour drawing in a central region of digitized fundus photographs, measuring 3,000 µm in diameter. To evaluate CDGAS progression, differences in pixels and square millimeters were calculated by equivalent tests. Results: Forty-nine patients completed the visits over the 12-month period (ES = 27 and CO = 22). Mean pixel values increased from 201.5 (11.33 × 10^–3 mm²) to 202.7 (11.39 × 10^–3 mm²) in the ES group and from 191.6 (10.77 × 10^–3 mm²) to 194.6 (10.94 × 10^–3 mm²) in the CO group. Finally, equivalence of CDGAS differences between ES and CO could be demonstrated. No exudative AMD was recorded during the study period. Conclusion: In our cohorts, no significant changes were found in CDGAS 12 months after cataract surgery. The MD3RI software could serve as an efficient, precise and objective tool for AMD quantification and monitoring in future trials.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 93%

Monitoring of Drusen and Geographic Atrophy Area Size after Cataract Surgery Using the MD3RI Tool for Computer-Aided Contour Drawing

Brunner

Mora²,

Fonseca³

et al. 2012

Ophthalmologica

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“…It suggests that the development of cataract or cataract surgery did not markedly influence the development of age-related macular degeneration. Both these studies, however, are contradictory to a number of studies, including an investigation of autopsy eyes [36], several case series [37][38][39], and population-based epidemiologic studies [23,24,[40][41][42], in which concerns were raised with regard to the potential of cataract surgery to accelerate progression to advanced, vision-threatening forms of AMD.…”

Section: Discussionmentioning

confidence: 99%

Association between asymmetry in cataract and asymmetry in age-related macular degeneration. The Beijing Eye Study

You

Cui

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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In an intra-individual, inter-eye comparison, avoiding interdependencies of systemic parameters, inter-eye difference was not significantly associated with any characteristics of age-related macular degeneration in either any type of cataract or in pseudophakia. This suggests that the development of cataract or cataract surgery did not markedly influence the development of age-related macular degeneration.

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“…Both conditions are quite common in the elderly and have overlapping symptoms, and deciding when to perform cataract surgery in patients with AMD can be difficult at best. Some clinicians believe that cataract surgery is beneficial in AMD patients whereas others fear that surgery could have deleterious effects; conflicting results from retrospective studies have led to further confusion regarding this issue (Kaiserman 2007;Sutter 2007).…”

Section: Overall Completeness and Applicability Of Evidencementioning

confidence: 99%

Surgery for cataracts in people with age-related macular degeneration

Casparis

Bressler

2007

Cochrane Database of Systematic Reviews

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Is Pseudophakia a Risk Factor for Neovascular Age-Related Macular Degeneration?

Abstract: The results do not support the hypothesis that pseudophakia is a major risk factor for the development of neovascular AMD.

Cited by 51 publications

References 22 publications

Monitoring of Drusen and Geographic Atrophy Area Size after Cataract Surgery Using the MD3RI Tool for Computer-Aided Contour Drawing

Monitoring of Drusen and Geographic Atrophy Area Size after Cataract Surgery Using the MD3RI Tool for Computer-Aided Contour Drawing

Association between asymmetry in cataract and asymmetry in age-related macular degeneration. The Beijing Eye Study

Surgery for cataracts in people with age-related macular degeneration

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