Is procalcitonin increased in cases of invasive amoebiasis? A retrospective, observational study

Recipon, Guillaume; Piver, Éric; Caille, Agnès; Pape, Patrice Le; Pihet, Marc; Pagès, Jean‐Christophe; Chandenier, J.; Désoubeaux, Guillaume

doi:10.1016/j.diagmicrobio.2015.08.014

Cited by 7 publications

(6 citation statements)

References 30 publications

(44 reference statements)

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“…A low serum albumin (< 2 g/dL) is found in almost all patients; however, an exceedingly low value is a poor prognostic marker[ 34 ]. Inflammatory biomarkers, such as C-reactive protein and procalcitonin have been found to be nonspecifically raised in most patients with ALA[ 34 , 59 , 61 ].…”

Section: Laboratory Evaluationmentioning

confidence: 99%

Amebic liver abscess: Clinico-radiological findings and interventional management

Priyadarshi¹,

Kumar²,

Anand³

2022

WJR

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In its classic form, amebic liver abscess (ALA) is a mild disease, which responds dramatically to antibiotics and rarely requires drainage. However, the two other forms of the disease, i.e. , acute aggressive and chronic indolent usually require drainage. These forms of ALA are frequently reported in endemic areas. The acute aggressive disease is particularly associated with serious complications, such as ruptures, secondary infections, and biliary communications. Laboratory parameters are deranged, with signs of organ failure often present. This form of disease is also associated with a high mortality rate, and early drainage is often required to control the disease severity. In the chronic form, the disease is characterized by low-grade symptoms, mainly pain in the right upper quadrant. Ultrasound and computed tomography (CT) play an important role not only in the diagnosis but also in the assessment of disease severity and identification of the associated complications. Recently, it has been shown that CT imaging morphology can be classified into three patterns, which seem to correlate with the clinical subtypes. Each pattern depicts its own set of distinctive imaging features. In this review, we briefly outline the clinical and imaging features of the three distinct forms of ALA, and discuss the role of percutaneous drainage in the management of ALA.

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Section: Laboratory Evaluationmentioning

confidence: 99%

Amebic liver abscess: Clinico-radiological findings and interventional management

Priyadarshi¹,

Kumar²,

Anand³

2022

WJR

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“…Notably, PCT and CRP levels are elevated mainly in bacterial and in some viral infections. Although they are not used in the diagnosis of parasitic infections, it was reported that PCT or CRP levels were high, especially in invasive parasitic infections involving the liver [16][17][18][19][20][21] . It was suspected that PCT and CRP levels would increase in the pathogenesis of fascioliasis, which mainly involves the liver and biliary tract.…”

Section: Introductionmentioning

confidence: 99%

Contested role of procalcitonin and C-reactive protein in the diagnosis of fascioliasis

CAKIR¹,

BILDEN

Çiçek

et al. 2022

Parasitologists United Journal

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Background: Procalcitonin (PCT) and C-reactive protein (CRP) are acute phase reactants indicating inflammation, particularly in bacterial infections. High PCT or CRP levels were proposed in malaria, invasive amoebiasis, babesiosis and schistosomiasis. Since liver is the sole habitat, it was hypothesized that PCT and CRP may have a role in the diagnosis of fascioliasis.Objective: The study aimed to investigate whether PCT and CRP have a role in the diagnosis of fascioliasis. Subjects and Methods: Fifty fascioliasis patients and 50 healthy blood donors in the same age range, as the control group, were included in the study. Fascioliasis was diagnosed by anti-Fasciola IgG ELISA, in addition, direct stool examinations (fresh smear and after sedimentation) were performed in both groups. Serum PCT and CRP levels were determined by I-chroma kits on I-CHROMA™ II device, and NFL BN-II immunonephelometry system, respectively. Results: There was no statistically significant difference of PCT and CRP values between the fascioliasis patient group and the control group (P> 0.05). Conclusion: It was concluded that PCT and CRP were not relevant parameters for diagnosis of fascioliasis.

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“…That procalcitonin is the response of the human body to a bacterial infection was first discovered by Dandona et al in 1990 [10]. A high level of PCT in the blood indicates not only severe bacterial infection and sepsis [11,12,13,14], but also postoperative complications [15,16,17,18]. To date, there are very few studies on the role of PCT in early detection of surgical site infections after cesarean section [19].…”

Section: Introductionmentioning

confidence: 99%

Sezaryen Sonrası Cerrahi Alan Enfeksiyonlarının Erken Dönem Tanısında Prokalsitonin ve C-reactive protein Ölçümlerinin Yeri

Gül

2021

Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Sezaryen sonrası ölçülen serum prokalsitonin (PKT) düzeylerinin cerrahi alan enfeksiyonu (CAE)'ların erken tanısında diğer enfeksiyon belirteçlerine gore üstün olup olmadığını belirlemeyi amaçladık. Gereç ve Yöntemler: Bu çalışma, Kasım 2018 ile Nisan 2019 tarihleri arasında Özel Hastane kadın doğum kliniğimizde elektif primer sezaryen ile doğum yapan 249 hasta üzerinde gerçekleştirildi. Postoperatif 6., 12. ve 24. saatlerde serum PKT, C-reaktif protein (CRP) ve beyaz kan hücresi sayılarının ölçümleri yapıldı. Hastalar postoperatif 2., 4. ve 7. günlerde CAE açısından incelendi. Bulgular: Katılımcıların 15'inde (%6) cerrahi alan enfeksiyonu gelişti. PKT, CAE'ların en hassas ve spesifik belirleyicisiydi. PKT için CAE'nın öngörülmesinde eğri altındaki alan 0.912 (% 95 CI: 0,79-1) ve kesme noktası 0,099 ng / ml , % 93,3 duyarlılık ve % 92,3 özgüllük idi (p <0.001). CAE tahmininde CRP eğri altındaki alan (EAA) 0.854 (% 95 CI: 0.782 -0.926) ve kesme noktası 16.95 mg/dL, %80 hassasiyet ve % 82,4 özgüllük idi. CAE'yi öngörmede beyaz kan hücresi için eğri altındaki alan (AUC) 0.819 (% 95 CI: 0.708-0.931) ve kesme noktası 18.8x109 /L, % 73,3 hassasiyet ve % 83,0 özgüllük idi. Sonuç: Serum PKT düzeyleri, sezaryen sonrası CAE'ların erken tanısında diğer konvansiyonel enfeksiyon belirteçlerinden daha duyarlı ve özgün bir belirteç olarak bulundu.

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Is procalcitonin increased in cases of invasive amoebiasis? A retrospective, observational study

Cited by 7 publications

References 30 publications

Amebic liver abscess: Clinico-radiological findings and interventional management

Amebic liver abscess: Clinico-radiological findings and interventional management

Contested role of procalcitonin and C-reactive protein in the diagnosis of fascioliasis

Sezaryen Sonrası Cerrahi Alan Enfeksiyonlarının Erken Dönem Tanısında Prokalsitonin ve C-reactive protein Ölçümlerinin Yeri

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