Is pregabalin effective and safe in total knee arthroplasty? A PRISMA-compliant meta-analysis of randomized-controlled trials

Han, Chao; Kuang, Ming-jie; Ma, Jianxiong

doi:10.1097/md.0000000000006947

Cited by 17 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pregabalin is an analgesic anticonvulsant with anxiolytic effects. It is frequently used in the treatment of chronic neuropathic pain but is increasingly used in the treatment of acute pain [17]. As a part of multimodal analgesia, pregabalin reduces opioid consumption and relieves postoperative pain in patients undergoing knee surgery [11].…”

Section: Discussionmentioning

confidence: 99%

The effects of pregabalin and adductor canal block on postoperative pain in arthroscopic anterior cruciate ligament reconstruction

et al. 2020

View full text Add to dashboard Cite

Materials and methods: A total of 51 American Society of Anaesthesiologists (ASA) classification I-II patients aged 18-70 years who were scheduled to undergo elective anterior cruciate ligament reconstruction were included in the study. Patients were randomized into groups P, A, and C. Patients in group P (n = 16), received 150 mg of preoperative oral pregabalin, patients in group A (n = 17) received postoperative adductor canal blockade, and patients in group C (n = 18) received neither adductor canal block nor pregabalin. Surgeries were performed under spinal anaesthesia with hyperbaric bupivacaine following monitorization. Demographic data along with block features, hemodynamic data, mean opioid consumption, numerical rating scale score, White's fast-track score, and postoperative adverse effects were recorded. Results: Fifty-seven patients were enrolled in the study, and 6 patients were excluded from the study; the data of 51 patients were included in the final analyses. Demographic characteristics and hemodynamic data were similar between the 3groups. Postoperative opioid consumption was significantly lower in groups A and P compared with group C (group P = 178.75 mg, group C = 318.61 mg, group A = 236.47 mg; P < 0.05). The regression of sensory block was significantly slower in group P (P < 0.05). The first analgesic requirement was earlier in group C than in groups P and A (P < 0.05). Patients in group P had higher fast-track scores at 8 h and 12 h compared with group C (P < 0.05); however, group A fast-track scores were similar to those of the other 2groups (P > 0.05). The rate of postoperative adverse effects was similar between the groups (P > 0.05). Conclusion: Preoperative pregabalin (150 mg) reduced postoperative opioid consumption as much as adductor canal block in patients undergoing anterior cruciate ligament reconstruction. The first analgesic requirement was earlier in group C than in groups P and A. In addition, pregabalin can prolong the duration of spinal sensory block and shorten the time required to achieve high fast-tracking scores. We recommend the use of both methods as a part of multimodal analgesia.

show abstract

Section: Discussionmentioning

confidence: 99%

The effects of pregabalin and adductor canal block on postoperative pain in arthroscopic anterior cruciate ligament reconstruction

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Furthermore, studies suggest that pregabalin can also be used in the treatment of postoperative pain [4] . In a meta-analysis study, Han et al [17] performed a comparison of the drugs used for acute pain treatment and concluded that pregabalin, also known as an adjuvant, increases analgesic outcome.…”

Section: Discussionmentioning

confidence: 99%

Assessment of anxiety and effect of preemptive analgesia on patients administered ambulatory anesthesia in endoscopy unit

Çaparlar¹

2019

Haydarpasa Numune Med J

View full text Add to dashboard Cite

Introduction: Endoscopy and colonoscopy are gold standards for the diagnosis and treatment of gastrointestinal diseases. The success of ambulatory gastrointestinal procedures rely on examination, the cooperation of the patient, drug selection, experience of anesthesiologists with endoscopists. This study aims to assess preoperative anxiety arising from endoscopy and colonoscopy applied successively in endoscopy units, to take precautions accordingly and to compare dexketoprofen and paracetamol for preemptive analgesia. Methods: In this study, 150 patients (ASA I-II,18-60 years) who were scheduled to go under endoscopy and colonoscopy were included. Demographic data (gender, age, BMI), American Society of Anesthesiologists(ASA) scores and education background were recorded. State-Trait Anxiety Inventory I-II(STAI I-II) testes were applied to the patients. Results: Patients were informed by the Numerical Rating Scale (NRS) in the endoscopy unit. Pregabalin was administered one hour before the procedure as per established procedures in all groups. Patients were divided into three groups, paracetamol in group P (n=20), dexketoprofen in group D (n=20), and saline in Group C (n=20) were administered. At the end of the procedure, patients above 2, according to the Ramsay Sedation Scale (RSS), were taken to the recovery room. Their pain levels were measured at minutes 5, 30, 60, and 120 following procedure using NRS. The times to reach above 9 of the modified Aldrete recovery score (MARS) were recorded. There was no difference concerning demographics, ASA, education, duration of anesthesia, endoscopist's and patient's satisfaction, duration of the procedure, and NRS levels. The time to reach MARS 9 was shorter in Group D than Group P, and C. Total propofol consumption throughout sedation was less in Group D compared to Group P and C. Discussion and Conclusion: It is necessary to recognize the anxiety of the patients in the gastrointestinal procedure and to take precautions. By applying preemptive analgesia, the total anesthetic dose can be reduced, and discharge time can be shortened.

show abstract

“…A cold pack was used on the surgical site and a single dose of 10 mg intravenous dexamethasone was administered when patients arrived inpatient unit [ 9 , 11 ]. Postoperative oral Loxoprofen sodium (Loxonin; 60 mg three times daily) and Pregabalin (Lyrica; 75 mg twice daily) were administered for pain [ 12 , 13 ]. A standard venous thromboembolism prophylaxis protocol combined mechanical and chemical prophylaxis was adopted for all patients [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

Modified Robert Jones bandage can not reduce postoperative swelling in enhanced-recovery after primary total knee arthroplasty without intraoperative tourniquet: a randomized controlled trial

Wang

Zhou

et al. 2018

BMC Musculoskelet Disord

View full text Add to dashboard Cite

BackgroundCompression therapy is commonly used to reduce lower limb swelling and blood loss after knee surgery. This study was performed to investigate whether modified Robert Jones bandage (MRJB) as a postoperative compression therapy is necessary for enhanced-recovery primary total knee arthroplasty without the tourniquet application.MethodsIn this prospective randomized controlled trial, 90 patients were grouped into 2 groups randomly. The experimental group received compression therapy with MRJB from toes to thigh for 24 h and the control group received no compression therapy. Knee swelling, blood loss, range of motion (ROM), pain, patient reported comfort level and complications were recorded.ResultsNo significant differences were observed between the two groups when we compared knee swelling. Similarly, no significant difference on postoperative blood loss, pain, ROM, complications was found. However, patients in control group had significantly higher comfort ratings than compression group during the first 24 h.ConclusionsMRJB is not routinely indicated in enhanced-recovery primary total knee arthroplasty without tourniquet application.Trial registrationThe trial was registered in the Chinese Clinical Trial Registry (ChiCTR-INR-16010177) dated 18th December 2016.

show abstract

Is pregabalin effective and safe in total knee arthroplasty? A PRISMA-compliant meta-analysis of randomized-controlled trials

Cited by 17 publications

References 27 publications

The effects of pregabalin and adductor canal block on postoperative pain in arthroscopic anterior cruciate ligament reconstruction

The effects of pregabalin and adductor canal block on postoperative pain in arthroscopic anterior cruciate ligament reconstruction

Assessment of anxiety and effect of preemptive analgesia on patients administered ambulatory anesthesia in endoscopy unit

Modified Robert Jones bandage can not reduce postoperative swelling in enhanced-recovery after primary total knee arthroplasty without intraoperative tourniquet: a randomized controlled trial

Contact Info

Product

Resources

About