Is preeclampsia an independent predictor of diastolic dysfunction? A retrospective cohort study

Guirguis, George; Aziz, Michael M.; Liang, Claire; Williams, Shauna F.; Apuzzio, Joseph J.; Bilinski, Robyn T.; Mornan, Adenieki J.D.; Shah, Leena

doi:10.1016/j.preghy.2015.10.001

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Severe PE was diagnosed based on the definition in Williams Obstetrics (23rd edition). 14 These patients had no history of preexisting or chronic hypertension but showed systolic blood pressure >160 mm Hg or diastolic blood pressure >110 mm Hg at least in two occasions, accompanied by significant proteinuria (>300 mg/24 hours) or symptoms in multiple organs such as pulmonary edema, seizures, oliguria, abnormal liver enzymes associated with persistent epigastric or right upper-quadrant pain, or persistent and severe central nervous system symptoms after the 20th week of gestation. The clinical characteristics of all the subjects are shown in Table 1.…”

Section: Patients and Clinical Samplesmentioning

confidence: 99%

The lncRNA small nucleolar RNA host gene 5 regulates trophoblast cell proliferation, invasion, and migration via modulating miR‐26a‐5p/N‐cadherin axis

Yang

Lan

et al. 2018

J of Cellular Biochemistry

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Pre-eclampsia (PE) is a pregnancy-specific disease characterized by the occurrence of hypertension and proteinuria after two weeks of gestation. Long noncoding RNAs (lncRNAs) are emerging as key regulators in PE development.This study aims to investigate the role of lncRNA, small nucleolar RNA host gene 5 (SNHG5), in the pathogenesis of PE. The expression of SNHG5 was significantly downregulated in placental tissues from patients with severe PE compared normal controls. Overexpression of SNHG5 promoted trophoblast (HTR-8/SVneo) cell proliferation, invasion, and migration, and flow cytometry results showed that SNHG5 overexpression inhibited apoptosis and caused a decrease of cell population at the G 0 /G 1 phase and an increase of cell population at the S phase, while knockdown of SNHG5 had the opposite effects. The interaction between SNHG5 and miR-26a-5p was predicted by bioinformatics analysis and confirmed by luciferase reporter assay and RNA immunoprecipitation, and miR-26a-5p was negatively regulated by SNHG5; miR-26a-5p expression was upregulated in PE placental tissues and was inversely correlated with SNHG5 expression. Furthermore, miR-26a-5p was predicted to target the 3′ untranslated region of N-cadherin, which was confirmed by luciferase reporter assay, and miR-26a-5p overexpression suppressed N-cadherin expression in HTR-8/SVneo cells. N-cadherin mRNA expression was downregulated in PE placental tissues and was positively correlated with SNHG5 expression.Both overexpression of miR-26a-5p and knockdown of N-cadherin suppressed HTR-8/SVneo cell invasion and migration, and also attenuated the effects of SNHG5 on the cellular functions of HTR-8/SVneo cells. In conclusion, our study suggested that SNHG5 promotes trophoblast cell proliferation, invasion, and migration at least partly via regulating the miR-26a-5p/N-cadherin axis. K E Y W O R D Sinvasion and migration, miR-26a-5p, N-cadherin, pre-eclampsia (PE), small nucleolar RNA host gene 5 (SNHG5), trophoblast J Cell Biochem. 2019;120:3173-3184.wileyonlinelibrary.com/journal/jcb

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Section: Patients and Clinical Samplesmentioning

confidence: 99%

The lncRNA small nucleolar RNA host gene 5 regulates trophoblast cell proliferation, invasion, and migration via modulating miR‐26a‐5p/N‐cadherin axis

Yang

Lan

et al. 2018

J of Cellular Biochemistry

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“…During pregnancy, patients with early-onset preeclampsia had higher LV mass, larger LV volumes and lower LV ejection fraction (LVEF) than normotensive pregnant and non-pregnant women[ 17 ]. These findings were subsequently implemented with evidence of diastolic LV dysfunction[ 18 – 20 ] and worse myocardial strain on speckle tracking echocardiograms[ 21 ]. Findings during pregnancy were more severe in early onset preeclampsia than in term preeclampsia[ 22 ] and paralleled by increases in plasma natriuretic peptide levels[ 17 , 18 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study

Bokslag¹,

Franssen

Alma³

et al. 2018

PLoS ONE

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BackgroundSystemic inflammation, endothelial dysfunction and deficient vascularization of either uterus or myocardium are mechanistic hallmarks of early-onset preeclampsia and heart failure with preserved ejection fraction (HFpEF). HFpEF is especially prevalent in elderly women and preceded in middle age by preclinical left ventricular (LV) diastolic dysfunction.To detect if preeclampsia predisposes to HFpEF at later age, echocardiographic indices of LV function and of LV structure and biomarkers of systemic inflammation and of endothelial dysfunction were compared in middle-aged women with a history of early-onset preeclampsia or uncomplicated pregnancy.Methods and findingsMiddle-aged women with a history of early-onset preeclampsia (n = 131) or uncomplicated pregnancy (n = 56) were prospectively recruited 9 to 16 years after pregnancy.Women with a history of preeclampsia had higher body mass index (p = 0.006), blood pressure (p<0.001) and plasma levels of interleukin-6 (p = 0.005) and soluble intercellular adhesion molecule-1 (sICAM-1) (p = 0.014). They had thicker septal (p = 0.001) and posterior (p = 0.003) LV walls and worse diastolic LV function evident from reduced mean mitral annular lengthening velocity (E’mean; p = 0.007) and higher ratio of early diastolic mitral flow velocity (E) over E’mean (E/E’mean; p<0.001). Differences of sICAM-1, E’mean and E/E’mean remained significant after accounting for BMI and blood pressure.ConclusionsHistory of preeclampsia predisposes in middle age to worse LV diastolic function, which could increase the likelihood of later HFpEF development. This predisposition derives not only from persistent cardiovascular risk but may also be caused by persistent endothelial dysfunction hindering adequate vascularization in the uterus during pregnancy and in the myocardium in middle age.

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“…In concordance with these results, Guirguis et al found more frequent diastolic dysfunction in patients with pre-eclampsia. Furthermore, we demonstrated that other variants of HDP were also associated with diastolic dysfunction [19].…”

Section: Discussionmentioning

confidence: 75%

Comparison between invasive and non-invasive assessment of blood pressure in hypertensive disorders of pregnancy

et al. 2021

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Background The management of hypertensive disorders of pregnancy (HDP) during hospitalization requires an accurate blood pressure (BP) measurement, mainly by invasive intra-arterial reading. Nevertheless, little is known about the precision of non-invasive (NI) central BP measurements in HDP. We aimed to assess the accuracy of NI central BP assessment in comparison to invasive BP measurement in HDP. This cross-sectional study included all patients with HDP that were admitted to university hospitals for high BP control, from December 2018 till December 2019, and 10 healthy matched non-hypertensive controls. Patients were compared for demographic, anthropometric, and echocardiographic data. In all subjects, invasive BP assessment was done by radial arterial cannulation and NI assessment of BP was performed by an oscillometric automated device (Mobil-O-Graph); the comparison was done after initial control of BP. Results One hundred patients were included and divided into 3 groups (pre-existing hypertension (HTN), gestational HTN, and pre-eclampsia). There was no statistically significant difference between NI central and invasive methods in measuring both systolic BP (SBP) (126.39 ± 14.5 vs 127.43 ± 15.3, p = 0.5) and diastolic BP (82.41 ± 9.0 vs 83.78 ± 8.9, p = 0.14) among the total studied population. A strong positive correlation was found between NI central and invasive SBP (r = 0.96, p < 0.001). HDP was associated with an increase in arterial stiffness, left ventricular diastolic dysfunction, and complications. Conclusion Non-invasive measurement of BP using oscillometric automated devices is as accurate as the invasive method, and it is a practical safe method in pregnant women with hypertensive disorders (CTR no. = NCT04303871).

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Is preeclampsia an independent predictor of diastolic dysfunction? A retrospective cohort study

Cited by 16 publications

References 27 publications

The lncRNA small nucleolar RNA host gene 5 regulates trophoblast cell proliferation, invasion, and migration via modulating miR‐26a‐5p/N‐cadherin axis

The lncRNA small nucleolar RNA host gene 5 regulates trophoblast cell proliferation, invasion, and migration via modulating miR‐26a‐5p/N‐cadherin axis

Early-onset preeclampsia predisposes to preclinical diastolic left ventricular dysfunction in the fifth decade of life: An observational study

Comparison between invasive and non-invasive assessment of blood pressure in hypertensive disorders of pregnancy

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