(1) Serum nitric oxide (NO) production is increased in normal pregnancy than in the normal non-pregnancy. (2) Maternal and fetal serum NO levels are increased significantly in pre-eclampsia and eclampsia, which possibly represents a compensatory/protective mechanism to maintain blood flow and limit platelets aggregation in the fetal-maternal circulations. (3) The increase in NO production is directly related to the severity of pre-eclampsia; this would be of diagnostic significance for the prediction of the severity of this syndrome.

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(1) Placental NOS activity and NO production are significantly increased in pre-eclampsia and eclampsia than those of normal pregnancy; this increase was directly related to the severity of this disorder. (2) Such increase possibly represents a physiologic adaptive response to overcome the increased placental vascular resistance and to minimize platelet and leukocyte adhesion to the surface of placental villi or within the intervillous spaces.

At 2-year follow-up, thermal balloon endometrial ablation is effective in menorrhagia treatment. Increased age, shorter uterine depth and adequate balloon pressure can be predictive factors for successful treatment.

Abstract:Objective: The study was carried out to assess the knowledge, attitude towards, and practice of contraception and the factors that could affect its use among Saudi women in Aseer region of Saudi Arabia. Methods: This cross-sectional and hospital-based study was conducted in Aseer Region, Saudi Arabia, during one year (January, 2014 -December, 2014. Five-hundred women of reproductive age (18-45 year) were interviewed regarding their knowledge, attitude and practices of contraception. The inquiries were recorded by a predesigned questionnaire. Questions on methods of contraception known and source of knowledge and their practices were recorded. Results: The mean ± SD of age was 32.7 + 7.2 years. (99.2%) of women heard and had knowledge of contraception, while (0.8%) said they did not know anything about contraception. (377 subjects, 75.4%) used contraception, while 123 subjects (24.6%) did not. Oral pill method of contraception was the most popular method known and practiced (87.0%, 32.2% respectively). The media seemed to be the major source of information (40.8%). In response to the reason for non-use, the majority said they wanted more children (10.2%). The major reason for the use of contraception was to limit family size (32.0%). The majority (79.6%) of women had good attitude towards contraception. Conclusion: The present study concludes that a significant proportion of respondents have good knowledge about contraception. But practice of contraception and compliance is low. Desire of more children is one of the major factors among reasons of the non-use of contraception.