Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus?

Demir, Nihat; Peker, Erdal; Ece, İ̇brahim; Ağengin, Kemal; Bulan, Keziban; Tuncer, Oğuz

doi:10.3109/14767058.2015.1067296

Cited by 26 publications

(35 citation statements)

References 22 publications

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“…The internal layer of the ductus becomes hypoxic with ductal constriction leading to neointimal cushion formation and extensive vascular remodeling 140,141 . This mechanism of vascular remodeling is similar to the development of atherosclerosis seen after vascular wall injury 140,142 . Cytokines, such as IL-17, play a role in vascular remodeling in atherosclerosis and may similarly mediate remodeling of the ductus 143,144 .…”

Section: The Role Of Il-17 In the Patent Ductus Arteriosussupporting

confidence: 54%

Section: The Role Of Il-17 In the Patent Ductus Arteriosusmentioning

confidence: 99%

“…The ductus in a premature infant is thinner which can decrease vasoconstriction requiring other means of closure including platelet aggregation and thrombus formation 140,142 . IL-17 increases platelet activation and platelet adhesion which may be needed for ductal closure in the premature infant 142,146 . In addition, premature infants are more likely to have a symptomatic PDA if there is a history of chorioamnionitis 147 or history of postnatal inflammation 148 including early onset and late onset sepsis 149,150 .…”

Section: The Role Of Il-17 In the Patent Ductus Arteriosusmentioning

confidence: 99%

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IL‐17 in neonatal health and disease

Lawrence

Ruoss

Wynn

2017

American J Rep Immunol

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Over the last few years, scientific interest in the cytokine IL-17A has intensified as its role in human health and disease has been elucidated. Discovered almost a quarter century ago, IL-17A is known to have poor biologic activity when acting alone, but attains robust actions when working synergistically with potent mediators of proinflammatory immune responses, such as IL-6 and IL-8. IL-17A is produced by specialized innate immune cells that protect host barriers from the outside world. Like sentries, these innate immune cells can “sound the alarm” through increased production of IL-17A, causing activation and recruitment of primed neutrophils and monocytes when pathogens escape initial host defenses. In this way, IL-17A promulgates mechanisms responsible for pathogen death and clearance. However, when IL-17A pathways are triggered during fetal development, due to chorioamnionitis or in utero inflammatory conditions, IL-17A can instigate and/or exacerbate fetal inflammatory responses that increase neonatal morbidities and mortality associated with common neonatal conditions such as sepsis, bronchopulmonary dysplasia (BPD), patent ductus arteriosus (PDA), and necrotizing enterocolitis (NEC). This review details the ontogeny of IL-17A in the fetus and newborn, discusses how derangements in its production can lead to pathology, and describes known and evolving therapies that may attenuate IL-17A-mediated human conditions.

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Section: The Role Of Il-17 In the Patent Ductus Arteriosussupporting

confidence: 54%

Section: The Role Of Il-17 In the Patent Ductus Arteriosusmentioning

confidence: 99%

Section: The Role Of Il-17 In the Patent Ductus Arteriosusmentioning

confidence: 99%

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IL‐17 in neonatal health and disease

Lawrence

Ruoss

Wynn

2017

American J Rep Immunol

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“…Also, in another meta‐analysis, platelet count appeared lower in premature infants who did not respond to the first medical treatment . In the following limited number of studies, the role of platelet indices in ductal patency was investigated, but no clear relationship was found . There is also scant data regarding the value of plateletcrit (PCT) in PDA.…”

Section: Introductionmentioning

confidence: 99%

A promising, novel index in the diagnosis and follow‐up of patent ductus arteriosus: Red cell distribution width‐to‐platelet ratio

Bekmez

Tayman

Büyüktiryaki

et al. 2018

Clinical Laboratory Analysis

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“…Larger platelets are probably younger, more reactive, and create more thrombogenic factors (11). Therefore, large platelets are more agreeable and, metabolically and enzymatically more active compared to small platelets and normal platelets (12). The MPV is known to be a clinical significance in thromboembolic diseases.…”

Section: Discussionmentioning

confidence: 99%

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

Telo¹,

Kırkıl²,

Kaman³

et al. 2017

J Turgut Ozal Med Cent

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Aim: The aim of this study is to investigate the changes in platelet indexes, including mean platelet volume (MPV), platelet distribution width (PDW) and platelet count (PC), in patients with acute pulmonary embolism (PE), in addition to evaluating the diagnostic value in clinical forms. Material and methods: The study consisted of 84 patients with PE and the control group consisted of 40 healthy subjects. PE patients were divided into two groups in accordance with the clinical forms as 60 submassive and 24 nonmassive. The differences in platelet count, MPV, PDW, PC, D-dimer, and other indicators were analyzed between the two groups. Venous peripheral blood samples to measure the MPV, PDW and PC were acquired on admission. Results: MPV levels were found to be statistically higher in the submassive group compared to the nonmassive group and the control group (p<0.01 and p<0.001, respectively). PDW levels were found to be statistically higher in the submassive group compared to the non-massive group and control group (p=0.027 and p<0.001, respectively). PC was significantly lower in the submassive group compared to the non-massive group and control group (p=0.022 and p<0.001, respectively). It was determined that a positive correlation existed between the MPV and right ventricular diameter (RVD) (r=0.27, p<0.01). Conclusion: High MPV and PDW levels and low PC may be indicators of the severity of acute PE. Also, the correlation between the MPV and RVD suggests that MPV can be used as a marker of right ventricular function.

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Is platelet mass a more significant indicator than platelet count of closure of patent ductus arteriosus?

Abstract: Platelet mass may be a more significant indicator than platelet count of closure of hPDA in preterm newborns.

Cited by 26 publications

References 22 publications

IL‐17 in neonatal health and disease

IL‐17 in neonatal health and disease

A promising, novel index in the diagnosis and follow‐up of patent ductus arteriosus: Red cell distribution width‐to‐platelet ratio

Does platelet indices play a role in the distinction of pulmonary embolism clinical forms?

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