A promising, novel index in the diagnosis and follow‐up of patent ductus arteriosus: Red cell distribution width‐to‐platelet ratio

Bekmez, Buse Özer; Tayman, Cüneyt; Büyüktiryaki, Mehmet; Çetinkaya, Aslıhan Köse; Çakır, Ufuk; Derme, Turan

doi:10.1002/jcla.22616

Cited by 23 publications

(26 citation statements)

References 26 publications

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“…However, no correlation was detected between thrombocytopenia and hsPDA in numerous other studies. 12,17,28 In our study, we did not observe a correlation between hsPDA and platelet count or thrombocytopenia in the first hours of life. Moreover, we showed that platelet count was not associated with outcomes of pharmacological treatment of hsPDA, corroborating other reports.…”

Section: Discussioncontrasting

confidence: 62%

“…Moreover, we showed that platelet count was not associated with outcomes of pharmacological treatment of hsPDA, corroborating other reports. 3,[11][12][13][14][15]29 Discrepancies in the results of these various studies may be attributed to differences in neonatal thrombocytopenia and hsPDA definitions, gestational ages of the studied infants, exclusion criteria, timing of platelet count, and comorbidities, as well as the retrospective nature of most of the studies.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are studies in the literature suggesting that thrombocytopenia on the first postnatal day is an important risk factor for hsPDA, 6,[9][10][11] other studies have shown that it has no effect. [12][13][14][15][16][17] Various studies investigating the relationship between platelet indices and hsPDA identified increased platelet distribution width (PDW), [11][12][13] high mean platelet volume (MPV) and low platelet mass, 15 and high red cell distribution width (RDW) to platelet ratio (RPR) 12 as risk factors for hsPDA. However, two other studies found no correlation between hsPDA and indices such as PDW, MPV, and platelet mass.…”

mentioning

confidence: 99%

“…[19][20][21] However, there are limited data on its relationship with neonatal morbidities. 12,22 MPV-to-platelet ratio (MPR) is another indicator of inflammatory status whose relationship with neonatal morbidities has not been investigated. [23][24][25] We hypothesized that of these parameters, RPR, MPV, platelet mass, and MPR may be used in addition to echocardiography to predict hsPDA and its response to pharmacological treatment.…”

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confidence: 99%

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Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

et al. 2019

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Objective The aim of this study was to assess the utility of early postnatal platelet indices in the prediction of hemodynamically significant patent ductus arteriosus (hsPDA) and its response to pharmacological treatment in preterm infants. Study Design The medical records of 971 infants with gestational age < 30 weeks and birth weight < 1,500 g were analyzed retrospectively. Infants with hsPDA comprised the study group and those without hsPDA comprised the control group. Complete blood count results were recorded, and red cell distribution width-to-platelet ratio (RPR) and platelet mass were calculated. Results A total of 481 infants, 169 in the hsPDA group and 312 in the control group, were included. In terms of platelet indices, the hsPDA group showed significantly lower mean platelet volume (MPV) and platelet mass, whereas RPR was significantly higher (p < 0.05, respectively). Multiple logistic regression analysis showed that RDS (relative ratio [RR]: 2.39; 95% confidence interval [CI]: 1.45–3.93; p < 0.001), MPV < 7.85 (RR: 3.71; 95% CI: 2.29–6.01; p < 0.001), and RPR > 0.070 (RR: 5.33; 95% CI: 3.28–8.65; p < 0.001) were independent risk factors for hsPDA. Conclusion Low MPV and platelet mass and high RPR in the first hours of life are risk factors for hsPDA and hsPDA refractive to pharmacological treatment with ibuprofen in preterm infants.

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confidence: 62%

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confidence: 99%

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Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

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“…However, there are limited studies on the use of RDW in neonates for monitoring patients and determining their prognosis. It has been reported that the increase in RDW in preterm infants may be associated with patent ductus arteriosus, bronchopulmonary dysplasia, and LOS . A high RDW value has been shown to reflect unstable erythropoiesis and inflammatory stress in critically ill neonates .…”

Section: Discussionmentioning

confidence: 99%

Red cell distribution width as a predictor of late‐onset Gram‐negative sepsis

Doğan

Varal

2020

Pediatrics International

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Background Late‐onset sepsis (LOS) remains an important cause of morbidity and mortality in preterm infants. In this study, our aim was to investigate the red‐cell distribution width (RDW) levels during a LOS episode, and its association with the type of growing microorganism and mortality. Methods Preterm infants with culture‐proven sepsis during their neonatal intensive care unit stay were enrolled. Red‐cell distribution width levels were obtained in the first 4 h of postnatal life and at the onset of the LOS episode, and compared for these time frames. The study cohort was divided into two groups according to the type of the growing microorganism. The RDW levels were then assessed in intra‐ and inter‐group analyses. Results Eighty‐six infants were included in the final analysis. RDW levels were increased in the study cohort after a LOS attack (P < 0.001). Infants with Gram‐negative sepsis showed a significant increase in their RDW levels, but they remained unchanged in infants with Gram‐positive sepsis (P < 0.001 and P = 0.4, respectively). An RDW cut‐off of >19.50% was related with a sensitivity of 87% and a specificity of 81% for predicting late‐onset Gram‐negative sepsis (P < 0.001). Logistic regression analysis showed a positive association of RDW with mortality when adjusted for covariants (adjusted odds ratio: 1.40; 95% confidence interval: 1.02–1.80; P = 0.03). Conclusions Our findings show that RDW levels increased during a LOS episode in preterm infants, which was especially evident in Gram‐negative infections. We believe that these findings may be of importance in the early diagnosis and prognosis of LOS in preterm infants.

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The relationship between platelet indices and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis

Ding

Zhang

et al. 2020

Eur J Pediatr

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A promising, novel index in the diagnosis and follow‐up of patent ductus arteriosus: Red cell distribution width‐to‐platelet ratio

Abstract: Red cell distribution width-to-platelet ratio and PCT may be promising supportive tools for the diagnosis and prediction of pharmacotherapy success.

Cited by 23 publications

References 26 publications

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

Useful Platelet Indices for the Diagnosis and Follow-Up of Patent Ductus Arteriosus

Red cell distribution width as a predictor of late‐onset Gram‐negative sepsis

The relationship between platelet indices and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis

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