Is pelvic radiation beneficial in the postoperative management of stage Ib squamous cell carcinoma of the cervix with pelvic node metastasis treated by radical hysterectomy and pelvic lymphadenectomy?A report from the presidential panel at the 1979 Annual Meeting of the Society of Gynecologic Oncologists

Morrow, C. Paul; Shingleton, Hugh M.; Austin, J. Max; Averette, H.E.; Girtanner, Robert E.; Webb, Maurice J.; Masterson, John G.; Morley, George W.

doi:10.1016/0090-8258(80)90071-2

Cited by 161 publications

(50 citation statements)

References 5 publications

(1 reference statement)

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“…Conclusions cannot be drawn regarding the efficacy of adjuvant pelvic irradiation from some reports in the literature [3,14]. Several retrospective studies, however, show the efficacy of adjuvant treatment.…”

Section: Discussionmentioning

confidence: 83%

Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

et al. 1998

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Section: Discussionmentioning

confidence: 83%

Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

et al. 1998

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“…Postoperative pelvic radiation for patients with lymph node metastases and parametrial extension of lymph-blood vessel invasion has been investigated in several studies. Some authors reported a slightly improved survival rate [41,53,68,86], but the majority [13,16,30,47,60,91,120,139] did not find a better survival rate with this additional treatment. Unfortunately all these studies were retrospective and used non-randomized analysis.…”

Section: The Impact Of Treatmentmentioning

confidence: 99%

A review of prognostic factors in early-stage carcinoma of the cervix (FIGO I B and II A) and implications for treatment strategy

Bommel¹,

Lindert²,

Kock³

et al. 1987

European Journal of Obstetrics & Gynecology and Reproductiv

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Several prognostic factors in stages I B and II A cervical carcinoma have been widely studied to define groups of patients with a poor prognosis. Most of these factors are interrelated. The characteristics which should be regarded as main factors have not yet been defined, because the studies reported were based on mainly retrospective and non-randomized analysis. Reviewing the literature, lymph node metastasis, differentiation grade, tumor size, parametrial extension, lymphblood vessel invasion and cervical invasion seem to be prognostically important factors, which suggests that the subdivision of patients according to the FIG0 classification alone is inaccurate. It seems useful to define subgroups of patients according to tumor characteristics, determined after surgical treatment and accurate histologic examination of the surgical specimen. Patients with one or more of these tumor features need additional treatment to improve survival. The current treatment modalities, such as postoperative radiotherapy, have not been thoroughly evaluated, but doubt exists as to their efficacy. Data in the literature suggest that particularly patients with para-aortic or multiple pelvic lymph node metastasis (> 3) have already developed distant metastases at the time of primary treatment and therefore need adjuvant systemic therapy. Patients with tumors larger than 4 cm in diameter, differentiation grade III, lymph-blood vessel invasion or cervical invasion (of more than 70%) seem to have high recurrence rates at both pelvic and distant sites, indicating that there is also a need for better pelvic control.

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“…In our study we have excluded those cases of incomplete resection of the cancer and will report on this topic elsewhere. As Morrow (1980) has pointed out, however, it is undoubtedly safer to note merely that the cure rate for such cases according to clinical stage cannot be increased with the use of postoperative radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

The effects of postoperative radiotherapy in cases of invasive carcinoma of the uterine cervix.

Sato¹,

Yajima²,

Yamauchi³

et al. 1982

Tohoku J. Exp. Med.

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investigation was made of the effects on cure rate of postoperative radiotherapy following radical hysterectomy with lymphadenectomy for cases of invasive carcinoma of the uterine cervix performed over 7 years between 1969 and 1975 at the Department of Obstetrics and Gynecology, Tohoku University Hospital. For cases in which resection was complete but the cancer extended to the pelvic wall, the 5 year survival rate was similar to that in comparable cases of the same clinical stage regardless of whether or not postoperative radiotherapy was employed. The 5 year survival rate in cases undergoing postoperative radiotherapy because of lymph node metastasis was lower than that of cases where the lesion approached the pelvic wall and for which postoperative radiotherapy was employed. An investigation of the 5 year survival rate among those cases with lymph node metastasis and receiving postoperative radiotherapy indicated that survival in cases with metastasis to only one lymph node was similar to that of cases of the same clinical stage which received the operation only, whereas the survival rate of cases with multiple lymph node involvement was markedly lower. ----cervical cancer; postoperative radiotherapy; treatment of cervical cancer; external irradiation

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Cited by 161 publications

References 5 publications

Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

Adjuvant radiotherapy after radical hysterectomy of the cervical cancer

A review of prognostic factors in early-stage carcinoma of the cervix (FIGO I B and II A) and implications for treatment strategy

The effects of postoperative radiotherapy in cases of invasive carcinoma of the uterine cervix.

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