Is oocyte maturity influenced by ovulation trigger type in oocyte donation cycles?

Jones, Benjamin P; Alchami, Ali; Gonzalez, Xavier Viñals; Arshad, Falak; Green, Joy; Bracewell‐Milnes, Timothy; Saso, Srdjan; Smith, Richard; Serhal, Paul; Nagi, Jara Ben

doi:10.1080/14647273.2019.1671614

Cited by 8 publications

(3 citation statements)

References 25 publications

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“…but in our study the rate of OHSS in hCG trigger very high 15.2% vs9.0% vs 7%. (30) In our study, as we expected, the OHSS level in the hCG group was higher, which is justi able. The choice of trigger in our study was based on the clinician's preference.…”

Section: Discussionsupporting

confidence: 74%

Comparison of GnRH Agonist, hCG, and Dual Trigger for Final Oocyte Maturation in ICSI Cycle. A Case Control Study

Mahmoudinia

Khadem

khazaee

et al. 2021

Preprint

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BACKGROUND:Gonadotrophin-releasing hormone (GnRH) agonist has been proposed as an alternative drug to human chorionic Gonadotropin (hCG) for triggering. The purpose of this study to analyze the effects of three types of trigger hCG, GnRH-a or combine of them (dual) on quality of oocyte and embryoand ovarian hyperstimulation syndrome (OHSS)in the ICSI cycle. METHODS:A prospective case control study was conducted on 320 women who referred to Milad, IVF Center, Mashhad, Iran, between May 2016 and June 2019. All patients underwent antagonist protocol and were classified according to the type of trigger in three groups, 118 patients in the GnRH-agroup, 49 patients in the hCG group, and 153in dualgroup. The oocytes were retrieved after 36 hours of injection of the trigger. The outcome measures were the number ofmetaphase I,metaphase II oocyte, Germinal vesicle (GV) oocytes, high-quality embryo and rate of OHSS.RESULTS:Three groups were not significantly different in terms of the proportion of retrieved oocytes, the number of embryos, M I oocyte, M II oocyte, and the number of GV oocytes. The quality of embryos between the three groups was difference significantly (p<.05). In comparison to dual and GnRH-a group trigger, women who received hCG group had a higher number of OHSS, and the number of severe OHSS in dual trigger was higher than GnRH-a vs and hCG groups.CONCLUSIONS: GnRH agonist alone and dual trigger (hCG, GnRHagonist) can be as effective as hCG trigger. GnRH agonist is preferable in high risk patient. Therefore, it should be used according to the patient’s condition.

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Section: Discussionsupporting

confidence: 74%

Comparison of GnRH Agonist, hCG, and Dual Trigger for Final Oocyte Maturation in ICSI Cycle. A Case Control Study

Mahmoudinia

Khadem

khazaee

et al. 2021

Preprint

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“…A study suggested that a dual trigger using GnRHa and low-dose hCG may be associated with a modest increase in oocyte yield, both in terms of number and maturity, compared to GnRHa single trigger [15]. However, Jones et al found that the dual trigger of GnRHa plus 2000 IU hCG did not improve the oocyte maturation rate compared with GnRHa single trigger for donated oocyte cycles [19]. In addition, another study showed that the addition of hCG (1500-5000 IU) to GnRHa trigger did not improve the oocyte maturation rate in normal and low responders undergoing planned oocyte cryopreservation, and it suggested that GnRHa trigger alone is an appropriate choice for those patients regardless of the risk of OHSS [31].…”

Section: Discussionmentioning

confidence: 99%

“…However, for oocyte donors suspected of normal and high response, GnRHa trigger maximizes mature oocyte yields but offers a signi cant reduction in OHSS risk compared to the dual trigger of GnRHa and hCG 2500 IU [19]. Therefore, there is insu cient evidence regarding the impact of the dual trigger on oocyte maturity and reproductive outcomes in high responders.…”

Section: Introductionmentioning

confidence: 99%

Effect of GnRH Agonist Alone or Combined With Different Low-dose hCG on Cumulative Live Birth Rate for High Responders in GnRH Antagonist Cycles: a Retrospective Study

Tang

Chen

et al. 2021

Preprint

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Background: There is insufficient evidence regarding the impact of dual trigger on oocyte maturity and reproductive outcomes in high responders. Thus, we aimed to explore the effect of gonadotropin-releasing hormone agonist (GnRHa) trigger alone or in combination with different low-dose human chorionic gonadotropin (hCG) regimens on rates of oocyte maturation and cumulative live birth in high responders who underwent a freeze-all strategy in GnRH antagonist cycles.Methods: A total of 1343 cycles were divided into three groups according to different trigger protocols: group A received GnRHa 0.2 mg (n=577), group B received GnRHa 0.2 mg and hCG 1000 IU (n=403), and group C received GnRHa 0.2 mg and hCG 2000 IU (n=363). Results: There were no significant differences in age, body mass index, and rates of oocyte maturation, fertilization, available embryo, and top-quality embryo between the groups. However, the incidence of moderate to severe ovarian hyperstimulation syndrome (OHSS) was significantly different between the three groups (0% in group A, 1.49% in group B, and 1.38% in group C). For the first frozen embryo transfer (FET) cycle, there were no significant differences in the number of transferred embryos and rates of implantation, clinical pregnancy, live birth, and early miscarriage between the three groups. Additionally, the cumulative ongoing pregnancy rate and cumulative live birth rate were not significantly different between the three groups. Similarly, there were no significant differences in gestational age, birth weight, birth height, and the proportion of low birth weight among subgroups stratified by singleton or twin.Conclusions: GnRHa trigger combined with low-dose hCG (1000 IU or 2000 IU) did not improve oocyte maturity and embryo quality and was still associated with an increased risk of moderate to severe OHSS. Therefore, for high responders treated with the freeze-all strategy, the GnRHa single trigger is recommended for final oocyte maturation, which can prevent the occurrence of moderate to severe OHSS and obtain satisfactory pregnancy and neonatal outcomes in subsequent FET cycles.

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Effect of GnRH agonist trigger with or without low-dose hCG on reproductive outcomes for PCOS women with freeze-all strategy: a propensity score matching study

Wang,

Wan,

et al. 2023

Arch Gynecol Obstet

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Is oocyte maturity influenced by ovulation trigger type in oocyte donation cycles?

Cited by 8 publications

References 25 publications

Comparison of GnRH Agonist, hCG, and Dual Trigger for Final Oocyte Maturation in ICSI Cycle. A Case Control Study

Comparison of GnRH Agonist, hCG, and Dual Trigger for Final Oocyte Maturation in ICSI Cycle. A Case Control Study

Effect of GnRH Agonist Alone or Combined With Different Low-dose hCG on Cumulative Live Birth Rate for High Responders in GnRH Antagonist Cycles: a Retrospective Study

Effect of GnRH agonist trigger with or without low-dose hCG on reproductive outcomes for PCOS women with freeze-all strategy: a propensity score matching study

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