Is obstetric and neonatal outcome worse in fetuses who fail to reach their own growth potential?

Danielian, Peter; Allman, A. C. J.; Steer, Philip

doi:10.1111/j.1471-0528.1992.tb13779.x

Cited by 66 publications

(50 citation statements)

References 6 publications

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“…Over the years, other methods to individualize the growth standard have been proposed 63–67. The regression method66–67, in particular, deserves further attention.…”

Section: The Individualized Approaches To Define Fetal Size Abnormmentioning

confidence: 99%

Defining normal and abnormal fetal growth: promises and challenges

Zhang

Merialdi

Platt

et al. 2010

American Journal of Obstetrics and Gynecology

229

170

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Normal fetal growth is a critical component of a healthy pregnancy and influences the long-term health of the offspring. However, defining normal and abnormal fetal growth has been a long-standing challenge in clinical practice and research. The authors review various references and standards that are widely used to evaluate fetal growth, and discuss common pitfalls of current definitions of abnormal fetal growth. Pros and cons of different approaches to customize fetal growth standards are described. The authors further discuss recent advances towards an integrated definition for fetal growth restriction. Such a definition may incorporate fetal size with the status of placental health measured by maternal and fetal Doppler velocimetry and biomarkers, biophysical findings and genetics. Although the concept of an integrated definition appears promising, further development and testing are required. An improved definition of abnormal fetal growth should benefit both research and clinical practice.

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“…Over the years, other methods to individualize the growth standard have been proposed 63–67. The regression method66–67, in particular, deserves further attention.…”

Section: The Individualized Approaches To Define Fetal Size Abnormmentioning

confidence: 99%

Defining normal and abnormal fetal growth: promises and challenges

Zhang

Merialdi

Platt

et al. 2010

American Journal of Obstetrics and Gynecology

229

170

View full text Add to dashboard Cite

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“…A number of investigators have previously questioned the extent to which fetal growth restriction that stops short of a small for gestational age (SGA) outcome should also be of clinical concern. Conflicting conclusions have been reported (e.g., Altman and Hytten 1989, Danielian et al 1992, Stratton et al 1995) and it is challenging to draw a single viewpoint from these studies because they were not uniform in their design.…”

Section: Introductionmentioning

confidence: 99%

Downward percentile crossing as an indicator of an adverse prenatal environment

Lampl

Gotsch

Kusanovic

et al. 2008

Annals of Human Biology

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Background Postnatal health sequelae associated with low birth weight have been attributed to ‘poor fetal growth’ from inferred adverse prenatal environments; risks augmented by infant growth rates. Identifying prenatal growth-restricting events is essential to clarify pathways and mechanisms of fetal growth. Aim The specific aim of this investigation was to examine whether an episode of preterm labor may compromise fetal growth. Subjects and methods Fetal size at the end of the second trimester and birth were compared among a sample of women with uncomplicated pregnancies (n=3167) and those who experienced preterm labor (<37 weeks) and subsequently delivered at term (>=37 weeks, n=147). Fetal weight was estimated from ultrasound measures and changes in weight standard scores across the third trimester investigated significant centile-crossing (> 0.67 standard deviation score change). Results Fetuses delivered at term after an episode of preterm labor were smaller at birth relative to their peers than at the end of the second trimester, and were 47% more likely to experience clinically significant downward centile crossing (p<0.05) than their peers (OR 1.47, 95% CI 1.04-2.07) Conclusion An episode of preterm labor may signal an adverse prenatal environment for term-delivered neonates. Epidemiologically silent events in the natural history of pregnancy are an understudied source of fetal growth compromise as inferred by small birth size among peers.

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“…Multiple factors play a role in neurodevelopmental outcome of these prematurely born infants. Pregnancy-induced hypertension (PIH), chorioamnionitis, premature rupture of membranes (PROM), and maternal smoking significantly alter intrauterine conditions that lead to small for gestational age (SGA) status, and also may alter the neurodevelopmental outcome of prematurely born infants (1)(2)(3)(4)(5)(6). Mothers expected to have premature delivery are often given antenatal steroids to improve pulmonary maturity.…”

mentioning

confidence: 99%