Changes in Neurotrophin Levels in Umbilical Cord Blood From Infants With Different Gestational Ages and Clinical Conditions

Chouthai, Nitin; Sampers, Jackie; Desai, Nirmala S.; Smith, George M.

doi:10.1203/01.pdr.0000061588.39652.26

Cited by 96 publications

(87 citation statements)

References 43 publications

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“…Circulating BDNF levels have been shown to correlate with cortical levels in newborn rats, and BDNF mRNA levels are low in the embryonic brain and increase rapidly during the early postnatal period [37,38] . In children, it has been shown that serum levels of BDNF increase rapidly after birth [28] and that BDNF levels increase with increased birth age [39,40] .…”

Section: Discussionmentioning

confidence: 99%

Proliferative Retinopathy Is Associated with Impaired Increase in BDNF and RANTES Expression Levels after Preterm Birth

Hellgren

Willett²,

Engström³

et al. 2010

Neonatology

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Background: Extremely preterm delivery is, amongst other complications, associated with retinopathy of prematurity (ROP). Untreated, ROP can progress to visual impairment and blindness due to an overgrowth of new vessels in the retina and vitreous cavity. Objective: The aim of this study was to identify cytokine markers within the first weeks of life that could be used to predict the risk for development of ROP later in life. Methods: Serum levels of 27 different cytokines in infants born at gestational weeks 23–30 were analyzed using a multiplex immunoassay method and compared between infants who did not develop ROP and infants who later developed proliferative ROP. In addition, mRNA levels of brain-derived neurotrophic factor (BDNF) in retinas from mice exposed to hyperoxia were analyzed using quantitative real-time PCR. Results: At birth, serum levels of IL-5 were higher in infants with no ROP compared to infants with proliferative ROP. 10–14 days after birth, serum levels of BDNF and RANTES were lower in infants who later developed proliferative ROP compared to infants who did not develop ROP. Furthermore, mRNA expression levels of BDNF in retinas from mice exposed to hyperoxia were significantly lower at postnatal day 15 compared to retinas from mice in room air. Conclusions: These results indicate that BDNF and RANTES may be important factors in the selective vulnerability of ROP development in preterm infants.

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Section: Discussionmentioning

confidence: 99%

Proliferative Retinopathy Is Associated with Impaired Increase in BDNF and RANTES Expression Levels after Preterm Birth

Hellgren

Willett²,

Engström³

et al. 2010

Neonatology

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“…Other potential mechanisms involved in eliciting a differential response/recovery from hypoxic insult may include differences in VEGF expression and induction, 61 differences in BDNF expression level, induction, 62 and polymorphism 63 and polymorphisms in several cytokines and extracellular matrix components. 64,65 Thus, in this report we have documented significant differences in HIF-1␣ translation and responsiveness to SDF-1 in C57 and CD-1 NSCs (shaded aspects of the signaling pathways are illustrated in Figure 7).…”

Section: Discussionmentioning

confidence: 99%

Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal

Liu

Michaud

et al. 2009

The American Journal of Pathology

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Premature infants have chronic hypoxia, resulting in cognitive and motor neurodevelopmental handicaps caused by suboptimal neural stem cell (NSC) repair/ recovery in neurogenic zones (including the subventricular and the subgranular zones). Understanding the variable central nervous system repair response is crucial to identifying "at risk" infants and to increasing survival and clinical improvement of affected infants. Using mouse strains found to span the range of responsiveness to chronic hypoxia, we correlated differential NSC survival and self-renewal with differences in behavior. We found that C57BL/6 (C57) pups displayed increased hyperactivity after hypoxic insult; CD-1 NSCs exhibited increased hypoxia-induced factor 1␣ (HIF-1␣) mRNA and protein, increased HIF-1␣, and decreased prolyl hydroxylase domain 2 in nuclear fractions, which denotes increased transcription/translation and decreased degradation of HIF-1␣. C57 NSCs exhibited blunted stromal-derived factor 1-induced migratory responsiveness, decreased matrix metalloproteinase-9 activity, and increased neuronal differentiation. Adult C57 mice exposed to hypoxia from P3 to P11 exhibited learning impairment and increased anxiety. These findings support the concept that behavioral differences between C57 and CD-1 mice are a consequence of differential responsiveness to hypoxic insult, leading to differences in HIF-1␣ signaling and resulting in lower NSC proliferative/migratory and higher apoptosis rates in C57 mice. Information gained from these studies will aid in design and effective use of preventive therapies in the very low birth weight infant population. Preterm birth is known to result in cognitive and motor disabilities and recent evidence suggests that there can be significant recovery over time in some patients.

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“…It has been indicated that serum BDNF levels are correlated to cortical levels in newborn rats [35]. Neurotrophins may play crucial roles in antenatal and postnatal brain development [36]. Previous studies have suggested that BDNF is expressed in early developmental stages and is involved in cell migration resulting in the formation of laminated structures of the cerebral cortex by acting on Cajal-Retzius neurons and subplate neurons in an autocrine or local paracrine manner [29,37].…”

Section: Discussionmentioning

confidence: 99%

“…When our findings are considered, the duration rather than severity of GAD during pregnancy seems to have a stronger effect on fetal circulating BDNF levels. Some authors have suggested that cord blood BDNF level in mature infants is higher than in premature infants, and that BDNF levels increase with increasing gestational age [36]. Huppi et al [41] indicated that cerebral gray matter exhibits a linear increase in relative intracranial volume of approximately 1.4% per week between 29 and 41 gestational weeks.…”

Section: Discussionmentioning

confidence: 99%

Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels

Uğuz

Sönmez

Sahingoz

et al. 2013

Journal of Psychosomatic Research

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Changes in Neurotrophin Levels in Umbilical Cord Blood From Infants With Different Gestational Ages and Clinical Conditions

Cited by 96 publications

References 43 publications

Proliferative Retinopathy Is Associated with Impaired Increase in BDNF and RANTES Expression Levels after Preterm Birth

Proliferative Retinopathy Is Associated with Impaired Increase in BDNF and RANTES Expression Levels after Preterm Birth

Strain Differences in Behavioral and Cellular Responses to Perinatal Hypoxia and Relationships to Neural Stem Cell Survival and Self-Renewal

Maternal generalized anxiety disorder during pregnancy and fetal brain development: A comparative study on cord blood brain-derived neurotrophic factor levels

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