Is Neutrophil/Lymphocyte Ratio Predict to Short-term Mortality in Acute Cerebral Infarct Independently from Infarct Volume?

Neutrophil to Lymphocyte Ratio Predicts Short-Term Functional Outcome in Acute Ischemic Stroke

“…Several studies have supported the hypothesis that the NLR is an independent factor for predicting short-term mortality and unfavorable functional outcome in AIS [23,24,32,34,41]. Tokgoz et al reported that the NLR at the time of hospital admission might be a predictor of short-term mortality independent of infarct volume in patients with AIS [42]. Furthermore, the NLR has been reported to be an independent risk factor for the incidence of AIS in generally healthy populations [2].…”

The Predictive Effect of the Neutrophil-to-Lymphocyte Ratio (NLR) on the Mortality of Acute Ischemic Stroke and its Subtypes: a Retrospective Cross-Sectional Study

“…High NLR ratios may be associated with vascular inflammation in both acute coronary diseases and in AIS, and the size of the infarct volume is proportional to the NLR ratio, independent of the etiology (2, 4, 9, 13). In one study, an NLR threshold value of 5.0 was found to be predictive of mortality (4,9). Another study conducted among intracerabral hemorrhagic patients demonstrated that patients with an NLR of 7.35 had a higher rate of mortality (11).…”

“…Inflammatory activity develops within 6-24 h after the vascular pathology and plays an important role in ischemic damage (4). High NLR ratios may be associated with vascular inflammation in both acute coronary diseases and in AIS, and the size of the infarct volume is proportional to the NLR ratio, independent of the etiology (2, 4, 9, 13).…”

“…In general, increased serum WBC and neutrophil counts have been associated with poor outcomes in many disease conditions (5,8). An elevated neutrophil count is an early indicator of ischemic brain damage (9) and is associated with a poor prognosis at 3 months, larger infarct volumes, and increased stroke severity in the early stage of ischemia (4,14). The neutrophil response to vascular injury occurs within approximately 6-12 h in rat models (14) and Eurasian J Emerg Med 2016;15: 69-72 Lök and Gülaçtı NLR in Patients with Ischemic Stroke 6-24 h in human patients (9).…”

The prediction of neutrophil to lymphocyte ratio for outcomes in ischemic stroke

“…The association of NLR and 90-day mortality in patients with ischemic stroke might be influenced by confounding factors. Previous studies [18,33] reported some independent predictors for mortality, such as age, NIHSS and the volume of infarct. With multivariate regression analysis, Maestrini [20] and Brooks [21] adjusted the outcomes with onset-to-treatment, gender, atrial fibrillation, systolic BP, recanalization, application of tissue plasminogen activator (tPA), and they found that NLR was independently associated with 90-day mortality.…”