Is Nanotechnology Helping in the Fight Against COVID-19?

Cardoso, Valéria Maria de Oliveira; Moreira, Bruna Juliana; Comparetti, Edson José; Sampaio, Isabella; Ferreira, Leonardo Miziara Barboza; Lins, Paula Maria Pincela; Zucolotto, Valtencir

doi:10.3389/fnano.2020.588915

Cited by 29 publications

(21 citation statements)

References 308 publications

(291 reference statements)

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“…Many nano‐based formulations have been found to improve the target delivery and therapeutic efficacy of antiviral drugs (Lembo, Donalisio, Civra, Argenziano, & Cavalli, 2018). Thus, interest in nanotechnology has grown greatly since the beginning of the COVID‐19 pandemic, and various studies related to its potential contribution in different areas have been published (Abdul, Muhammad, Atta Ullah, Asmat, & Abdul, 2020; Aranda et al, 2020; Cardoso et al, 2020; Jindal & Gopinath, 2020; Jones et al, 2020; Talebian, Wallace, Schroeder, Stellacci, & Conde, 2020).…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review

Pilaquinga

Morey

Arias

et al. 2021

WIREs Nanomed Nanobiotechnol

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Several human coronaviruses (HCoVs) are distinguished by the ability to generate epidemics or pandemics, with their corresponding diseases characterized by severe respiratory illness, such as that which occurs in severe acute respiratory syndrome (SARS‐CoV), Middle East respiratory syndrome (MERS‐CoV), and, today, in SARS‐CoV‐2, an outbreak that has struck explosively and uncontrollably beginning in December 2019 and has claimed the lives of more than 1.9 M people worldwide as of January 2021. The development of vaccines has taken one year, which is why it is necessary to investigate whether some already‐existing alternatives that have been successfully developed in recent years can mitigate the pandemic's advance. Silver nanoparticles (AgNPs) have proved effective in antiviral action. Thus, in this review, several in vitro and in vivo studies of the effect of AgNPs on viruses that cause respiratory diseases are analyzed and discussed to promote an understanding of the possible interaction of AgNPs with SARS‐CoV‐2. The study focuses on several in vivo toxicological studies of AgNPs and a dose extrapolation to humans to determine the chief avenue of exposure. It can be concluded that the use of AgNPs as a possible treatment for SARS‐CoV‐2 could be viable, based on comparing the virus' behavior to that of similar viruses in in vivo studies, and that the suggested route of administration in terms of least degree of adverse effects is inhalation. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials

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Section: Introductionmentioning

confidence: 99%

Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review

Pilaquinga

Morey

Arias

et al. 2021

WIREs Nanomed Nanobiotechnol

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“…125 Mesoporous silica NPs provide drug co-delivery which can further be functionalized with ligands for active targeting of the viral cell. 8 AgNPs are better drug carriers for nucleic acid-based delivery with increased stability, protection from degradation, and controlled intracellular delivery. 126 AuNPs, carbon-based NPs, polymeric NPs, and vesicular nanocarriers have the potential to induce cytokine and antibody responses which are dependent on their size, shape, and surface chemistry.…”

Section: Organic and Inorganic Nanoparticlesmentioning

confidence: 99%

“…More than 80% of SARS-CoV-2 and host cell membrane interactions occur due to the presence of the S protein that is a special characteristic of the pathogenic cell for treatment strategies. 8 , 9 Human coronaviruses (HCoVs) are among the top 10 fatal viruses. SARS-CoV, one of the HCoVs, has a mortality rate of up to 10%.…”

Section: Introductionmentioning

confidence: 99%

“…life • Insufficient immune response • Higher doses -risk for side effects • Poor immunogenicity, non targeting, slow absorption • High storage and delivery requirements • Multiple targeting • Strong immuno stimulatory effects • Manageable size and surface properties • Reduced adverse effects • Controllable drug release • Strong stimulation of humoral and cellular responses Personal protective Equipment (PPE) • Shortage of supplies • Low filtration efficiency • Single-use (use-and-throw) -economic, eco-safety and waste management problems • Breathing pressure and heat dissipation • Ineffective disinfection and sanitizing • Reusable and improved bio-safety • Self-cleaning, high efficiency and effective disinfectants with antimicrobial and antiviral properties • Designing contamination-free equipment • Adding inherent virucidity to surfaces • Antimicrobial releasing self-sanitizing and surface topologies with viral self-deactivation International Journal of Nanomedicine 2021:16 https://doi.org/10.2147/IJN.S327334 DovePress 5719 very sensitive SARS-CoV-2 antibody detection in 5-15 min. Magnetic NPs (MNPs), especially iron oxide NPs, can easily separate the viral RNA from sample solutionwith their high magnetic efficiency to prepare analyte preconcentration, signal amplification, and biosensing 8,89. …”

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confidence: 99%

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Could Nanotechnology Help to End the Fight Against COVID-19? Review of Current Findings, Challenges and Future Perspectives

Yayehrad¹,

Siraj²,

Birhanu³

et al. 2021

IJN

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A serious viral infectious disease was introduced to the globe by the end of 2019 that was seen primarily from China, but spread worldwide in a few months to be a pandemic. Since then, accurate prevention, early detection, and effective treatment strategies are not yet outlined. There is no approved drug to counter its worldwide transmission. However, integration of nanostructured delivery systems with the current management strategies has promised a pronounced opportunity to tackle the pandemic. This review addressed the various promising nanotechnology-based approaches for the diagnosis, prevention, and treatment of the pandemic. The pharmaceutical, pharmacoeconomic, and regulatory aspects of these systems with currently achieved or predicted beneficial outcomes, challenges, and future perspectives are also highlighted.

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“…The side effects that the use of this antiviral therapy would cause are also not fully understood. Hence, case by case evaluation of antiviral therapy is necessary so as to understand its cross-reactivity in patients (Cardoso et al 2020 ). Considering all these shortcomings, there is need for development of alternative therapeutics which would be safe, tunable, target-specific, biocompatible, cost-effective, etc., for efficient treatment of diseases like COVID-19 (Gurunathan et al 2020 ).…”

Section: Treatment Of Covid-19mentioning

confidence: 99%

Use of nanotechnology in combating coronavirus

Gharpure

Ankamwar

2021

3 Biotech

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Recent COVID-19 pandemic situation caused due to the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affected global health as well as economics. There is global attention on prevention, diagnosis as well as treatment of COVID-19 infection which would help in easing the current situation. The use of nanotechnology and nanomedicine has been considered to be promising due to its excellent potential in managing various medical issues such as viruses which is a major threat. Nanoparticles have shown great potential in various biomedical applications and can prove to be of great use in antiviral therapy, especially over other conventional antiviral agents. This review focusses on the pathophysiology of SARS-CoV-2 and the progression of the COVID-19 disease followed by currently available treatments for the same. Use of nanotechnology has been elaborated by exploiting various nanoparticles like metal and metal oxide nanoparticles, carbon-based nanoparticles, quantum dots, polymeric nanoparticles as well as lipid-based nanoparticles along with its mechanism of action against viruses which can prove to be beneficial in COVID-19 therapeutics. However, it needs to be considered that use of these nanotechnology-based approaches in COVID-19 therapeutics only aids the human immunity in fighting the infection. The main function is performed by the immune system in combatting any infection.

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Is Nanotechnology Helping in the Fight Against COVID-19?

Cited by 29 publications

References 308 publications

Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review

Silver nanoparticles as a potential treatment against SARS‐CoV‐2: A review

Could Nanotechnology Help to End the Fight Against COVID-19? Review of Current Findings, Challenges and Future Perspectives

Use of nanotechnology in combating coronavirus

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