Is motor cortex excitability associated with personality factors? A replication study

Schecklmann, Martin; Landgrebe, Michael; Frank, Elmar; Sand, Philipp G.; Eichhammer, Peter; Hajak, Göran; Langguth, Berthold

doi:10.1016/j.ijpsycho.2011.11.013

Cited by 5 publications

(4 citation statements)

References 19 publications

(31 reference statements)

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“…To this aim, single TMS pulses were applied over the right motor cortex while measuring motor evoked potentials in the left index finger using electromyography. An initial TMS intensity of 50% was used and reduced until 4 motor evoked potentials of 8 TMS pulses could still be detected (Schecklmann et al, 2012;Rossini et al, 2015). For rTMS, the TMS intensity was set to 110% of each participant's individual motor threshold.…”

Section: Methodsmentioning

confidence: 99%

Attention Networks in the Parietooccipital Cortex Modulate Activity of the Human Vestibular Cortex during Attentive Visual Processing

et al. 2019

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Previous studies in human subjects reported that the parieto-insular vestibular cortex (PIVC), a core area of the vestibular cortex, is inhibited when visual processing is prioritized. However, it has remained unclear which networks in the brain modulate this inhibition of PIVC. Based on previous results showing that the inhibition of PIVC is strongly influenced by visual attention, we here examined whether attention networks in the parietooccipital cortex modulate the inhibition of PIVC. Using diffusion-weighted and resting-state fMRI in a group of female and male subjects, we found structural and functional connections between PIVC and the posterior parietal cortex (PPC), a major brain region of the cortical attention network. We then temporarily inhibited PPC by repetitive transcranial magnetic stimulation (rTMS) and hypothesized that the modulatory influence of PPC over PIVC would be reduced; and, as a result, PIVC would be less inhibited. Subjects performed a visual attentional tracking task immediately after rTMS, and the inhibition of PIVC during attentive tracking was measured with fMRI. The results showed that the inhibition of PIVC during attentive tracking was less pronounced compared with sham rTMS. We also examined the effects of inhibitory rTMS over the occipital cortex and found that the visual-vestibular posterior insular cortex area was less activated during attentive tracking compared with sham rTMS or rTMS over PPC. Together, these results suggest that attention networks in the parietooccipital cortex modulate activity in core areas of the vestibular cortex during attentive visual processing.

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Section: Methodsmentioning

confidence: 99%

Attention Networks in the Parietooccipital Cortex Modulate Activity of the Human Vestibular Cortex during Attentive Visual Processing

et al. 2019

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“…Although these findings are exploratory, these and other individual differences in capacity to attenuate/potentiate TMS-induced responses (eg, trait mindfulness) warrant further investigation. Perhaps suggestive of a similar effect of self-confidence on cortical excitability, an anxiety-related personality trait has previously been shown to influence motor cortex excitability in a paired-pulse TMS study 30 (note, however, that a replication of this study failed to find a similar effect 31 ).…”

Section: Discussionmentioning

confidence: 52%

Visual Attention Affects the Amplitude of the Transcranial Magnetic Stimulation-associated Motor-evoked Potential: A Preliminary Study With Clinical Utility

Bell

Lauer

Lench

et al. 2018

Journal of Psychiatric Practice

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Background The transcranial magnetic stimulation (TMS)-elicited motor evoked potential (MEP) is a valuable measure for clinical evaluations of various neurological disorders and is used to determine resting motor threshold for repetitive TMS dosing. While MEP amplitude is primarily associated with motor system function, there is evidence that nonmotor factors may also influence amplitude. This experiment tested the hypotheses that manipulation of 2 factors (visual attention, cognitive regulation) in human participants would significantly affect MEP amplitude. Methods Blocks of MEPs were recorded from the dominant right hand as participants (N = 20) were instructed to shift their visual attention (toward and away from the hand) and cognitively regulate the MEPs (rest, attenuate MEP amplitude, potentiate MEP amplitude) using their thoughts (6 blocks, 20 pulses/block, randomized, 110% resting motor threshold). Results MEP amplitude was significantly affected by the direction of visual attention; looking away from the hand led to higher amplitudes (P = 0.003). The relationship with cognitive regulation was nonsignificant. Conclusions The significant effect of visual attention on MEP suggests that this should be a standardized parameter in clinical and research studies. These data underscore the importance of rigorous reporting of methods and use of standardized practices for MEP acquisition and TMS dosing to ensure consistent clinical measurement and treatment.

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“…Further limitations of this analysis are that we did not control for conditions which are known to interfere with motor cortex excitability and plasticity or with tinnitus or both. For example, mental diseases such as anxiety or affective disorders are known in tinnitus as co-morbid condition [30] but also in modulating motor cortex excitability [12]. The same is the case for medication (e.g., GABAergic drugs) which can interfere with TMS related measures [31] and tinnitus [32].…”

Section: Discussionmentioning

confidence: 99%

“…The employed hardware setup required the analogue signal to be acquired with a band-pass filter between 20 Hz and 10 kHz and a digitization frequency of 5 kHz. Whereas these suboptimal filter settings yield the possibility of aliasing effects (according to the Nyquist theorem, a 2.5 kHz low pass filter should have been applied to the analogue signal), the small signal amplitudes for high frequencies render it unlikely that the recording setup may have biased or altered the present findings [12].…”

Section: Methodsmentioning

confidence: 96%

State- and Trait-Related Alterations of Motor Cortex Excitability in Tinnitus Patients

Schecklmann

Landgrebe²,

Kleinjung

et al. 2014

PLoS ONE

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Chronic tinnitus is a brain network disorder with involvement of auditory and non-auditory areas. Repetitive transcranial magnetic stimulation (rTMS) over the temporal cortex has been investigated for the treatment of tinnitus. Several small studies suggest that motor cortex excitability is altered in people with tinnitus. We retrospectively analysed data from 231 patients with chronic tinnitus and 120 healthy controls by pooling data from different studies. Variables of interest were resting motor threshold (RMT), short-interval intra-cortical inhibition (SICI), intra-cortical facilitation (ICF), and cortical silent period (CSP). 118 patients were tested twice - before and after ten rTMS treatment sessions over the left temporal cortex. In tinnitus patients SICI and ICF were increased and CSP was shortened as compared to healthy controls. There was no group difference in RMT. Treatment related amelioration of tinnitus symptoms were correlated with normalisations in SICI. These findings confirm earlier studies of abnormal motor cortex excitability in tinnitus patients. Moreover our longitudinal data suggest that altered SICI may reflect a state parameter, whereas CSP and ICF may rather mirror a trait-like predisposing factor of tinnitus. These findings are new and innovative as they enlarge the knowledge about basic physiologic and neuroplastic processes in tinnitus.

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Is motor cortex excitability associated with personality factors? A replication study

Cited by 5 publications

References 19 publications

Attention Networks in the Parietooccipital Cortex Modulate Activity of the Human Vestibular Cortex during Attentive Visual Processing

Attention Networks in the Parietooccipital Cortex Modulate Activity of the Human Vestibular Cortex during Attentive Visual Processing

Visual Attention Affects the Amplitude of the Transcranial Magnetic Stimulation-associated Motor-evoked Potential: A Preliminary Study With Clinical Utility

State- and Trait-Related Alterations of Motor Cortex Excitability in Tinnitus Patients

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