Is Microvascular Density an Independent Prognostic Factor in Squamous Cell Carcinoma of the Tongue?

Fernández, Mario M.; García-Rozado, Álvaro; Parente, Pablo

doi:10.1016/s2173-5735(07)70364-2

Cited by 3 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thirteen studies ( n = 1279 patients) were finally eligible for the MVD meta‐analysis and 6 of them found an inverse relationship between OS and MVD, that were positive studies, leaving 7 studies that were negative . Five studies ( n = 408 patients) were included for the LVD meta‐analysis.…”

Section: Resultsmentioning

confidence: 99%

Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta‐analysis of literature

Liu

Liang

et al. 2013

Head & Neck

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta‐analysis of literature

Liu

Liang

et al. 2013

Head & Neck

View full text Add to dashboard Cite

show abstract

“…We found only one study that used CD31 to correlate MVD and the prognosis of 43 patients with TSCC . In this small cohort study, Cox regression analysis did not indicate tumor vascularization as a prognostic factor of survival ( P = .59).…”

Section: Resultsmentioning

confidence: 65%

“…Although the expression of CD105 was reported to be an independent prognostic factor for survival by multivariate analysis according to the Cox regression model, prognostic value was not found when CD31 was assessed. This might be due to the small sample size in their study . There are two studies of FVIII in TSCC that reported contradictory results …”

Section: Discussionmentioning

confidence: 87%

“…In these studies, samples from patients with TSCC were used to evaluate the following vessel markers: CD34, CD31, CD105, FVIII, D2‐40, and LYVE‐1. For MVD markers, CD34 analysis was reported in 5 studies; Fernández et al studied CD31 and Chuang et al studied CD105 . Factor VIII was evaluated in 2 studies .…”

Section: Resultsmentioning

confidence: 99%

“…Some of the patients who underwent surgery were also given adjuvant radiotherapy, chemotherapy, or radiotherapy and chemotherapy . However, this information was either missing or not clearly stated in the other 5 studies …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review

et al. 2019

View full text Add to dashboard Cite

Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis through blood and lymphatic vessels. We undertook a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We carried out a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, lymphatic vessel endothelial hyaluronan receptor‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40+ vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40+ over factor VIII+ vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.

show abstract

Tumor-Infiltrating Macrophage and Microvessel Density in Oral Squamous Cell Carcinoma

et al. 2013

View full text Add to dashboard Cite

Tumor-associated macrophages (TAM) are the main cellular component in stroma of many tumors and participate in tumor angiogenesis. The aim of present study was to compare the microvascular density (MVD) and infiltrating macrophage density (IMD) in oral squamous cell carcinomas (OSCCs) with different histological grades. A histomorphometric analysis was performed after immunohistochemistry using antibodies such as von-Willebrand factor and CD68. A significant difference in MVD was found between well and moderately differentiated OSCCs (p<0.05). TAM were largely present in all studied tumors and the IMD was not different among OSCCs with different histological grades (p=0.381). Significant correlation between MVD and IMD was not observed (p=0.870). In conclusion, these results suggest that TAM and angiogenesis have an influence at different histological grades of OSCC. However, the lack of correlation between MVD and IMD could suggest that angiogenesis does not depend on the number of macrophages present in OSCC, but their predominant phenotype. Further studies involving distinct phenotypes of macrophages should be done to better understand the influence of TAM on the tumor angiogenesis.

show abstract

Is Microvascular Density an Independent Prognostic Factor in Squamous Cell Carcinoma of the Tongue?

Cited by 3 publications

References 19 publications

Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta‐analysis of literature

Intratumoral vessel density as prognostic factors in head and neck squamous cell carcinoma: A meta‐analysis of literature

Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review

Tumor-Infiltrating Macrophage and Microvessel Density in Oral Squamous Cell Carcinoma

Contact Info

Product

Resources

About