Is microalbuminuria a risk factor for hypertension in children with solitary kidney?

Shirzai, Ayoub; Yıldız, Nurdan; Bıyıklı, Neşe; Üstünsoy, Seyfettin; Benzer, Meryem; Alpay, Harika

doi:10.1007/s00467-013-2641-2

Cited by 27 publications

(20 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results support the need for a close follow-up of SFK patients, especially those with CAKUT in the SFK, as suggested by Corbani and Westland and many others [21,33,34], since at least a portion of these patients have an unfavorable prognosis and should be monitored more closely. As the accuracy of the creatinine-based equations is limited when GFR decreases, follow-up using a combined serum cystatin C/creatinine-based equation is recommended, if available [35,36].…”

Section: Discussionsupporting

confidence: 60%

Solitary Functioning Kidney in Children - A Follow-Up Study

Kolvek

Podracká

Rosenberger

et al. 2014

Kidney Blood Press Res

View full text Add to dashboard Cite

Background/Aims: This study aims to assess the cumulative incidence of elevated albuminuria, hypertension and decreased estimated glomerular filtration rate (eGFR) to identify possible renal injury in children with SFK. Methods: Forty-two children with SFK (23 boys; 27 congenital) were included in a prospective follow-up study. Blood pressure, albuminuria and eGFR were assessed repeatedly and the cumulative incidence rate of various forms of renal injury, overall and by type of etiology, were evaluated. Finally, renal injury-free survival was analyzed. Results: Mean follow-up was until age 11.3 years (SD 6.3 years). During follow-up, 16 (38.1%) patients met the criteria for renal injury, defined as hypertension (10; 23.8%), severely increased albuminuria (3; 7.1%) and a significantly impaired eGFR (<60ml/min/1.73m²) (5; 11.9%) and/or use of antihypertensive or antiproteinuric medication (11; 26.2%). Children with CAKUT in SFK had a significantly higher incidence of renal injury. The median time to develop renal injury was 12.8 years. Conclusion: A substantial proportion of children with SFK develop renal injury during childhood, especially those with CAKUT in the SFK. Therefore, close follow-up of albuminuria, blood pressure and eGFR are warranted to identify chronic kidney disease in its early stages.

show abstract

Section: Discussionsupporting

confidence: 60%

Solitary Functioning Kidney in Children - A Follow-Up Study

Kolvek

Podracká

Rosenberger

et al. 2014

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…The prevalence of microalbuminuria, which has been proposed by nephrologists to be a more accurate predictor of subclinical renal damage [66], has not been reported in patients undergoing NSS for BWTs.…”

Section: Functional Outcome After Nssmentioning

confidence: 97%

Current surgical standards of care in Wilms tumor

Kieran

Ehrlich

2016

Urologic Oncology: Seminars and Original Investigations

View full text Add to dashboard Cite

“…Bunu sistemik hipertansiyon, proteinüri ve glomerüloskle-roz izler (4) . Deneysel ve insanlar üzerinde yapılmış çalışmalar göstermektedir ki azalmış nefron sayısı kalan nefronlarda hiperfiltrasyona neden olarak böbrek fonksiyonlarındaki bozulma sonucu hipertansiyon ve proteinüriye neden olur (17) . Bu çalışmada, her iki grupta eGFR'na göre %58 oranında hiperfiltrasyon saptandı.…”

Section: Discussionunclassified

Clinical characteristics and follow-up results of unilateral renal agenesis and hypoplasia of children

Evrengül¹,

Ertan²,

Serdaroğlu³

et al. 2016

BUCH

View full text Add to dashboard Cite

ÖZAmaç: Az nefron sayısına sahip çocuklarda, yaşamlarının ilerleyen dönemlerinde hipertansiyon, proteinüri ve kronik böbrek yetmezliği gelişme riski yüksektir. Bu renal hasar, glomerüler hiperfiltrasyondam kaynaklanmaktadır. Bu çalışmanın amacı, tek taraflı agenezik ve hipoplazik böbreği olan çocukların klinik özelliklerinin ve izlem sonuçlarının değerlendirilmesidir. Yöntem: Celal Bayar Üniversitesi Tıp Fakültesi ve Dr. Behçet Uz Çocuk Hastanesinde takip edilen, tek taraflı renal agenezisi ve hipoplazisi olan hastaların klinik, radyolojik ve nükleer tıp inceleme bulguları değerlendirildi. Bulgular: Bu çalışma ortalama yaşı 8,9±4 yıl olan 30 (%60) erkek ve 20 (%40) kız hastadan oluşmaktaydı. Yirmi beş hasta renal agenezi, 25 hasta renal hipoplazi tanısı aldı. Laboratuvar incelemesinde ortalama serum kreatinin düzeyi 0,45±0,22 mg/dl ve tahmin edilen glomerüler filtrasyon hızı (eGFR) 144±30,3 ml/dk. idi. Yirmi dokuz (%58) hastada hiperfiltrasyon saptandı. Proteinüri ve hipertansiyonu olan 1 (%4) hasta vardı. On beş (%30) hastada ürolojik anamoli mevcuttu. Sonuç: Bu çalışmada, tek taraflı renal agenezisi ve hipoplazisi olan hastaların serum kreatinin düzeyi normal bulundu. Ancak bu hastaların 29 (%58) hiperfiltrasyon vardı. Hiperfiltasyonu olan çocukların çoğunda yaşamlarının ilerleyen döneminde renal hasar geliştiği için bu çocuk-ların doğumdan itibararen klinik takiplerinin yapılması gerekmektedir.Anahtar kelimeler: Konjenital böbrek hastalıkları, renal agenezi, renal hipoplazi ABSTRACT Objective: Children with an inadequate number of nephrons have an increased risk of developing hypertension, proteinuria and chronic kidney disease in later life. This renal injury is caused by glomerular hyperfiltration. The aim of this study is to evaluate clinical characteristics and follow-up results of the children with unilateral renal agenesis and hypoplasia. Methods: We evaluated the clinical, radiological, and nuclear medicine findings of the children with unilateral agenetic or hypoplastic kidneys who were followed at Celal Bayar University School of Medicine and Dr. Behcet Uz Children's Hospital between 2005 and 2012. Results: The study consisted of 30 (60%) males and 20 (40%) females with a mean age of 8.9±4 years. A total of 25 patients were with renal agenesis and 25 with renal hypoplasia were diagnosed. On laboratory evaluation, mean serum creatinine level was 0.45±0.22 mg/ dl and the mean estimated glomerular filtration rate (eGFR) was 144±30.3 ml/min. 29 patient (58%) had hyperfiltration according to an eGFR. Proteinuria and hypertension were noted in 1 (4%) patient. Urological anomalies were found in 15 patients (30%). Conclusion: Our study has determined that children with unilateral renal agenesis and hypoplasia had normal serum creatinine values. Howewer 29 patients (58%) had hyperfiltration according to eGFR. Because many children with hiperfiltration develop renal injury in later life, we emphasize the need for clinical follow-up in these patients starting at birth.

show abstract

Is microalbuminuria a risk factor for hypertension in children with solitary kidney?

Abstract: Children with SK have increased 24-h urinary MA excretion in the long term, and need prolonged follow-up to detect early deterioration of renal function and to prevent end-organ damage later in life.

Cited by 27 publications

References 37 publications

Solitary Functioning Kidney in Children - A Follow-Up Study

Solitary Functioning Kidney in Children - A Follow-Up Study

Current surgical standards of care in Wilms tumor

Clinical characteristics and follow-up results of unilateral renal agenesis and hypoplasia of children

Contact Info

Product

Resources

About