Is malnutrition a problem for multiple sclerosis patients?

Sorgun, Mine Hayriye; Yücesan, Canan; Tegin, Cuneyt

doi:10.1016/j.jocn.2013.12.024

Cited by 19 publications

(15 citation statements)

References 8 publications

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“…The λ// and λ┴ values are also increased in the lesions of patients with MS, as compared with those of deep gray matter. The present finding of increased FA and MD values in the thalamus are consistent with previous studies, including a report by Tovar-Moll et al (26), which suggested that an increase in the FA values in the thalamus correlates with thalamus reactive reconstruction (26–28). …”

Section: Discussionsupporting

confidence: 93%

Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis

Chen

Zhou

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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It remains challenging to locate occult lesions in patients with multiple sclerosis (MS). Diffusion tensor imaging (DTI) has been demonstrated to have the potential to identify occult changes in MS lesions. The present study used 3.0T magnetic resonance DTI to investigate the characteristics of different stages of MS lesions. DTI parameters, fractional anisotropy (FA), mean diffusivity (MD), λ// and λ┴ values of lesions were compared at the different stages of 10 patients with MS with 10 normal controls. The results demonstrated that FA and λ// values of MS silent and subacute lesions are decreased and MD and λ┴ values are increased, as compared with those of normal appearing white matter (NAWM) and normal controls. NAWM FA values were lower, and MD, λ//, and λ┴ values were higher than those of normal controls. It was also indicated that MS lesions had reduced color signals compared with the controls, and the lesion area appeared larger using DTI as compared with diffusion-weighted imaging. Furthermore, fiber abnormalities were detected in MS lesions using DTT, with fewer fibers connected to the lesion side, as compared with the contralateral side. FA, MD, λ// and λ┴ values in the thalamus were increased, as compared with those of normal controls (P<0.05); whereas MD, λ// and λ┴ values were significantly increased and FA values significantly decreased in the caudate nucleus and deep brain gray matter (DBGM) of patients with MS, as compared with the controls (P<0.05). λ// and λ┴ values were also significantly increased in the DBGM of patients with MS as compared with normal controls (P<0.05). The present findings demonstrate that DTI may be useful in the characterization of MS lesions.

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Section: Discussionsupporting

confidence: 93%

Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis

Chen

Zhou

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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“…Finally, it is important to recognize the limitations of questionnaire data in terms of accuracy, as some participants may not report their exact intake for various reasons. Moreover, we did not observe lower BMI levels or lower albumin levels in the patient group, suggesting that, despite lower intake in patients compared with controls, patients did not exhibit malnutrition by standard measures [15,16].…”

Section: Discussionmentioning

confidence: 70%

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

et al. 2019

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Background: Multiple sclerosis (MS) is a multifactorial disease with unknown etiology. It is assumed to result from interplay between genetic and environmental factors, including nutrition. We hypothesized that there are differences in nutritional parameters between MS patients and healthy controls. Methods: We examined 63 MS patients and 83 healthy controls. Nutritional status was determined by a dietary questionnaire, blood tests, quantification of cell membrane fatty acids, and serum antioxidant capacity. Results: We found that MS patients consumed a more limited diet compared with the healthy group, indicated by a lower average of 31 nutrients and by consumption levels of zinc and thiamine below the recommended daily intake. Both consumption and measured iron values were significantly lower in MS patients, with the lowest measures in the severe MS group. Long saturated fatty acids (>C16) were significantly lower in MS patients, while palmitic and palmitoleic acids were both higher. Serum total antioxidant capacity was significantly lower in the MS group compared with healthy controls, with the lowest measures in patients with severe MS. Conclusions: This study points to a possible correlation between nutritional status and MS. Understanding the clinical meaning of these findings will potentially allow for the development of future personalized dietary interventions as part of MS treatment.

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“…This could be related to changes in metabolism after the onset of disease or muscular atrophy as a result of reduced muscle activity resulting from neuronal impairment (17). The prevalence of chronic malnutrition, based on a serum albumin <3.5 mg/dL, was 11.8% in patients with MS and only 2% in patients suffering other chronic diseases (22).…”

Section: Dietsmentioning

confidence: 99%

Influence of Diet in Multiple Sclerosis: A Systematic Review

Bagur

Murcia

Jiménez-Monreal

et al. 2017

Advances in Nutrition

165

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Nutrition is considered to be a possible factor in the pathogenesis of the neurological disease multiple sclerosis (MS). Nutrition intervention studies suggest that diet may be considered as a complementary treatment to control the progression of the disease; a systematic review of the literature on the influence of diet on MS was therefore conducted. The literature search was conducted by using Medlars Online International Literature (MEDLINE) via PubMed and Scopus. Forty-seven articles met the inclusion criteria. The reviewed articles assessed the relations between macro- and micronutrient intakes and MS incidence. The patients involved used alternative therapies (homeopathy), protocolized diets that included particular foods (herbal products such as grape seed extract, ginseng, blueberries, green tea, etc.), or dietary supplements such as vitamin D, carnitine, melatonin, or coenzyme Q10. Current studies suggest that high serum concentrations of vitamin D, a potent immunomodulator, may decrease the risk of MS and the risk of relapse and new lesions, while improving brain lesions and timed tandem walking. Experimental evidence suggests that serum vitamin D concentration is lower during MS relapses than in remission and is associated with a greater degree of disability [Expanded Disability Status Scale (EDSS) score >3]. The findings suggest that circulating vitamin D concentrations can be considered a biomarker of MS and supplemental vitamin D can be used therapeutically. Other studies point to a negative correlation between serum vitamin B-12 concentrations and EDSS score. Vitamin B-12 has fundamental roles in central nervous system function, especially in the methionine synthase-mediated conversion of homocysteine to methionine, which is essential for DNA and RNA synthesis. Therefore, vitamin B-12 deficiency may lead to an increase in the concentration of homocysteine. Further research is clearly necessary to determine whether treatment with vitamin B-12 supplements delays MS progression.

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Is malnutrition a problem for multiple sclerosis patients?

Cited by 19 publications

References 8 publications

Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis

Magnetic resonance diffusion tensor imaging for occult lesion detection in multiple sclerosis

New Insights on the Nutrition Status and Antioxidant Capacity in Multiple Sclerosis Patients

Influence of Diet in Multiple Sclerosis: A Systematic Review

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