Is Male Gender a Prognostic Factor for Papillary Thyroid Microcarcinoma?

Lee, Yi Ho; Lee, Yu Mi; Sung, Tae Yon; Yoon, Jong Ho; Song, Dong Eun; Kim, Tae Yong; Baek, Jung Hwan; Ryu, Jin Suk; Chung, Ki-Wook; Hong, Suck Joon

doi:10.1245/s10434-017-5788-4

Cited by 45 publications

(39 citation statements)

References 18 publications

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“…Lee et al adapted propensity score matching analysis to investigate the prognostic role of male gender in PTMC, and their study concluded that it was not an independent prognostic factor for PTMC patients. 12 Previous studies demonstrated that PTMC with a larger tumor size might be biologically more similar to PTC. 13 However, the definition of PTMC (PTC measuring ≤10 mm in diameter) is still undecided.…”

Section: Discussionmentioning

confidence: 99%

<p>Clinical Analysis of Risk Factors for Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study of 3686 Patients</p>

Song¹,

Yan²,

Qiu³

et al. 2020

CMAR

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To investigate the risk factors for cervical lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC). Patients and Methods: In total, 3686 patients with PTMC who underwent initial surgery in Shanghai Jiao Tong University affiliated Sixth People's Hospital from January 2010 to December 2019 were retrospectively analyzed. Univariate and multivariate analyses were conducted to identify risk factors associated with cervical LNM.

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Section: Discussionmentioning

confidence: 99%

<p>Clinical Analysis of Risk Factors for Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study of 3686 Patients</p>

Song¹,

Yan²,

Qiu³

et al. 2020

CMAR

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“…In recent years, the association between gender and recurrence or survival of PTC has been debated. A previous study reported that the male was an independent clinical prognostic factor of poor outcome in PTC [32] , but not in PTMC [23] . Recently, Roh [33] have reported that there was no association between gender and LNM.…”

Section: Discussionmentioning

confidence: 87%

“…The correlation analysis revealed that the incidence of BRAF V600E mutation in male PTMC was much higher than in female. Lee [23] have recommended that the male could be as an independent prognostic factor for recurrence in non-PTMC, but it was not a prognostic factor in PTMC. In our study, the incidence of BRAF V600E mutation in FNAC was much higher than in FFPE which was consistent with some previous studies [24,25] , however, the LNM was related to BRAF V600E wild-type in PTMC which was inconsistent with other study [26] .…”

Section: Discussionmentioning

confidence: 99%

Comprehensive evaluation of risk factors for lymph node metastasis with papillary thyroid carcinoma in Southwest China patients

Yan

Wang

Luo

et al. 2020

Preprint

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Background: With the increasing incidences of papillary thyroid cancer(PTC), it is important to risk-stratify patients who may have more aggressive tumor biology. This study aimed to evaluate the risk factors for lymph node metastasis with PTC in Southwest China Patients which may provide a substantial reference for clinical diagnosis and treatment. Methods: 1045 PTCs (313 PTMC and 732 non-PTMC) between August 2016 and August 2019 were examined totally (including one Tibetan). BRAF V600E mutation was tested in all samples. The clinical data (gender, age, tumor location, sample source and pathological features) were retrospectively analyzed. Logistic regression analysis was performed to evaluate independent risk factors for LNM. Results: 181 out of 313 PTMC cases (57.8%), 145 out of 732 non-PTMC cases (19.8%) had BRAF V600E mutation, the Tibetan had a double mutation of BRAF L597Q and V600E in two separate lesions. In PTMC, significant difference in gender and sample source was found (BRAF V600E mutation vs. wild-type). In non-PTMC, significant difference in gender was found (BRAF V600E mutation vs. wild-type). The female (OR=1.952; 95% CI= 1.373-2.774; P= 0.00), age (31-59 years) and diameter of tumor ≤1cm (OR=3.273; 95% CI= 2.417-4.432; P=0.000) were significant independent predictors of LNM in all PTCs. In PTMC, the female (OR= 3.002; 95% CI= 1.654-5.446; P= 0.00) was a significant independent predictor of LNM. The tumor in left and right lobes simultaneously was an independent protective factor of LNM in each group (PTCs: OR=0.287; PTMC: OR=0.170; non-PTMC: OR=0.441, respectively). The BRAF V600E mutation rate of US-FNAC was much higher than FFPE in PTMC (P=0.018). Conclusions: Unlike previous research, our findings suggested that the female patients and diameter of tumor ≤1cm were risk factors for LNM and the BRAF V600E wild-type of PTMC might be more aggressive than others. Interestingly, the position of tumor in bilateral thyroid simultaneously was an independent protective factor for LNM. The US-FNA should be recommended for gene analysis (BRAF V600E) in PTMC. The BRAF L597Q mutation may be an independent aggressive factor in the Chinese Tibetan population. Hence, clinicians should consider an individualized treatment according to gene mutation, gender, age, tumor size and location of tumor in order to achieve a better therapeutic efficacy.

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“…The propensity score is a balancing score: The differences between groups on the covariates condensed down into a single score so if two groups balanced on the propensity score then balanced on all the covariates. PSM aims to reduce bias due to confounding variables [ 20 ]. In this study, we investigated the prognosis of ITC compared to PTC and FTC by analyzing the SEER database information from 2004–2013 using PSM methods due to the diversity of number of cases with different subtypes.…”

Section: Introductionmentioning

confidence: 99%

Propensity score matching analysis of the prognosis for the rare insular subtype of thyroid cancer based on SEER database

Liu

Zhao

et al. 2017

Oncotarget

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Insular thyroid carcinoma (ITC) is an uncommon thyroid malignancy with an unclear prognosis. The aim of this study was to determine the prognoses of patients with ITC. We investigated a large cohort of patients with differentiated thyroid cancer from the Surveillance, Epidemiology, and End Results (SEER) database who were registered between 2004 and 2013, and compared the prognosis of patients with ITC to those with classic papillary thyroid cancer (CPTC) and follicular thyroid cancer (FTC). Patient mortality was determined using Kaplan-Meier analyses with log-rank tests, as well as Cox proportional hazards regression analyses. The study cohort comprised of 165 patients with ITC, 5419 patients with FTC, and 60739 patients with CPTC. The rate of cancer-specific mortality per 1000 person-years for ITC was higher than that for CPTC or FTC. According to multivariate Cox regression analysis, however, the cancer-specific and all-cause mortality rates of ITC were similar to those of CPTC and FTC. The cancer-specific survival rate in patients with ITC was higher than that in patients with CPTC, but similar to that in patients with FTC, after adjusting for potentially influencing factors using propensity score matching analysis. These findings, which contrast with previously published data, provide new implications for the treatment of patients with ITC.

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Is Male Gender a Prognostic Factor for Papillary Thyroid Microcarcinoma?

Abstract: Male gender is an independent prognostic factor for recurrence in PTC >1 cm, but it is not a prognostic factor in PTMC.

Cited by 45 publications

References 18 publications

<p>Clinical Analysis of Risk Factors for Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study of 3686 Patients</p>

<p>Clinical Analysis of Risk Factors for Cervical Lymph Node Metastasis in Papillary Thyroid Microcarcinoma: A Retrospective Study of 3686 Patients</p>

Comprehensive evaluation of risk factors for lymph node metastasis with papillary thyroid carcinoma in Southwest China patients

Propensity score matching analysis of the prognosis for the rare insular subtype of thyroid cancer based on SEER database

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