Propensity score matching analysis of the prognosis for the rare insular subtype of thyroid cancer based on SEER database

Liu, Yan; Liu, Zeming; Zhao, Qiu; Hua, Teng; Chi, Shuqi; Huang, Tao; Wang, Hongbo

doi:10.18632/oncotarget.21826

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…SEER registries hold the highest level of certification of data quality provided by the North American Association of Central Cancer Registries (31). In addition, the index of completeness of case ascertainment of the program is 98%, making it the gold standard database for cancer analysis in the US (32)(33)(34). Therefore, the SEER database allows in-depth analysis of certain clinical issues.…”

Section: Discussionmentioning

confidence: 99%

Innovative analysis of distant metastasis in differentiated thyroid cancer

et al. 2020

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Differentiated thyroid cancer (DTC) is the most common thyroid cancer with a relatively high survival rate. The association between certain risk factors of distant metastasis (DM) remains uncertain. In order to assess the prognosis of patients with DTC better, the present study aimed to investigate the synergistic effects between histologic subtype, tumor size, lymph node metastasis (LNM) status and extrathyroidal extension (ETE) on the incidence of DM in DTC. Data of 96,788 patients with DTC were obtained from the Surveillance, Epidemiology and End Results database. The association between clinicopathological factors and DM was evaluated by univariate and multivariate analyses. The synergistic effects of relevant factors were determined by measuring the relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI). The results demonstrated that tumor size, LNM status, histologic subtype and ETE were independent risk factors for DM [odds ratio (OR)=2.433; P<0.001; OR=3.998; P<0.001; OR=6.266; P<0.001; and OR=3.873; P<0.001, respectively]. In addition, a significant additive synergistic effect on DM was identified between ETE and histologic subtype, ETE and LNM status, as well as between ETE and tumor size (RERI=34.097; AP=0.706; SI=3.585; RERI=6.425; AP=0.410; SI=1.781; and RERI=76.973; AP=0.864; SI=7.930, respectively). Therefore, the results of this study revealed that ETE with follicular thyroid histology, N1 stage or large tumor size may have a synergistic effect on the risk of DM in patients with DTC. These results suggested that individualized treatment may benefit patients with DTC, and when ETE coexists with one of the identified risk factors, radical treatments may be required.

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Section: Discussionmentioning

confidence: 99%

Innovative analysis of distant metastasis in differentiated thyroid cancer

et al. 2020

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“…T h e S E E R d a t a b a s e , w h i c h i n c l u d e s d a t a f r o m approximately 28% of the US population, is identified as the gold standard database for cancer analysis in this country (15)(16)(17)(18). Therefore, the present study was able to enroll a large number of patients to evaluate the influencing factors of DM in DTC and any synergic effects among them.…”

Section: Discussionmentioning

confidence: 99%

Synergic effects of histology subtype, tumor size, and lymph node metastasis on distant metastasis in differentiated thyroid cancer

Liu¹,

Chen²,

Huang³

et al. 2019

Ann. Transl. Med.

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Background: Detection of distant metastasis (DM) is important in differentiated thyroid cancer (DTC).This study aimed to investigate the synergic effects of histology subtype, tumor size, and lymph node metastasis (LNM) status on the occurrence of DM in DTC. Methods:We collected data of 96,788 patients with DTC. Univariate and multivariate analyses were conducted to identify the risk factors of DM. Relative excess risk of synergic effect, attributable proportion of synergic effect, and synergy index were then calculated to assess synergic effects. Further, Kaplan-Meier method using the log-rank test and receiver operating characteristic (ROC) curves were utilized.Results: Age at diagnosis (P<0.001), sex (P<0.001), race (P<0.01), tumor size (P<0.001), N stage (P < 0.001), histology subtype (P<0.001), and extrathyroidal extension (P<0.001) were risk factors for DM in both univariate and multivariate analyses. We also found a significant additive synergic effect between histology subtype and LNM, and between tumor size and LNM on DM in the DTC patients. In addition, patients with follicular thyroid cancer and N1 stage had the sharpest decline in cancer-specific survival curves (P<0.001) and all-cause survival curves (P<0.001) compared to patients with other combinations of histology subtype and N stage. Similar results were obtained in patients with larger tumors (≥10 mm) and N1 stage.The areas under the curve of histology subtype, tumor size, and LNM status were 0.569, 0.744, and 0.681, respectively.Conclusions: Age at diagnosis, sex, race, tumor size, N stage, histology subtype, and extrathyroidal extension are risk factors for DM in DTC patients. LNM has a synergic effect with either follicular thyroid histology or larger tumor size for higher risk of DM which is important for diagnosing DM.

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“…This study conformed to the provisions of the Declaration of Helsinki (as revised in 2013). The SEER database contains information on morbidity, prevalence, mortality, and population-based variables for patients worldwide, as well as details of the primary characteristics of the tumor, including site, spread, and histology where available, along with limited information regarding treatment, excluding chemotherapy (12).…”

Section: Data Sourcesmentioning

confidence: 99%

Novel analysis of prognosis of young patients with stage II differentiated thyroid cancer based on AJCC 8.0 and 6.0 criteria to implement the staging system

et al. 2020

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Background: The incidence of thyroid cancer among young adults is increasing; however, the clinical challenges specific to this population, such as diagnosis, reduced healthcare access, and inconsistent care, have received limited attention. Here, we conducted a subgroup analysis on a series of relatively young patients with differentiated thyroid carcinomas (DTCs), focusing on those with distant metastases at stage II, to obtain a deeper understanding of the factors influencing survival.Methods: Information on <45-or <55-year-old patients at any T/N stage with distant metastasis (M1) was extracted from the SEER database according to the staging system in the 6 th and 8 th American Joint Committee on Cancer (AJCC) editions, respectively. Patient mortality was evaluated using Cox proportional hazards regression analyses and Kaplan-Meier analyses with log-rank tests.Results: Both cancer-specific and all-cause mortality rates per 1,000 person-years for patients ≥35 years old significantly differed from those of patients <35 years old. DTC-specific survival curves also significantly differed between these age groups, according to both the AJCC 6.0 and 8.0-based analyses (P=0.0017 and P<0.001, respectively), as did patient survival curves (P=0.0003, P<0.001, respectively). The multivariate Cox regression model also revealed that poor OS was strongly predicted by race (P<0.001) in the analysis based on the criteria of 8 th AJCC staging system.Conclusions: Age is a risk factor for disease-specific and overall survival (OS) in young patients with stage II DTC, and young male patients exhibited poorer survival than females. Race also emerged as a potential risk factor for young patients in stage II. These findings offer guidance for improving the older and newer versions of the AJCC staging system.

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Propensity score matching analysis of the prognosis for the rare insular subtype of thyroid cancer based on SEER database

Cited by 4 publications

References 36 publications

Innovative analysis of distant metastasis in differentiated thyroid cancer

Innovative analysis of distant metastasis in differentiated thyroid cancer

Synergic effects of histology subtype, tumor size, and lymph node metastasis on distant metastasis in differentiated thyroid cancer

Novel analysis of prognosis of young patients with stage II differentiated thyroid cancer based on AJCC 8.0 and 6.0 criteria to implement the staging system

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