Is it possible to find presence of lactose in pharmaceuticals? — Preliminary studies by ATR-FTIR spectroscopy and chemometrics

Banaś, Agnieszka; Banaś, Krzysztof; Kalaiselvi, S. M. P.; Pawlicki, Bohdan; Kwiatek, Wojciech M.; Breese, Mark B. H.

doi:10.1016/j.saa.2016.08.003

Cited by 18 publications

(11 citation statements)

References 17 publications

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“…Infrared spectroscopy (FTIR) is a fast, inexpensive and sensitive technique used for the analysis of functional groups, and it identified chemical bonds in molecules. FTIR spectra include different peaks as a function of wavenumber (400–4000 cm −1 ) producing a sample profile as a distinctive and molecular fingerprint …”

Section: Resultsmentioning

confidence: 99%

Acylation of unprotected lactose with 1,18‐octadec‐9‐enedioyl chloride for the synthesis of monocatenary and bolaform agro‐based surfactants

et al. 2018

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Agro‐based surfactants have one of two hydrophilic or hydrophobic parts of vegetable origin. They can be produced from renewable and readily available resources. Carbohydrate fatty acid esters are non‐toxic, non‐ionic, and biodegradable agro‐based surfactants with applications in the pharmaceutical, cosmetic, and food industries. In this work, the chemical synthesis of agro‐based surfactants through lactose acylation with 1,18‐octadec‐9‐enedioyl chloride (Acyl‐Cl) was investigated at room temperature. The acylation reaction proved to be regioselective to the primary hydroxyl group of the glucose‐moiety in the lactose molecule and was promoted by an excess of lactose to produce higher substituted derivatives. Acyl‐Cl conversion was ∼98 % after 1 h of reaction. The production of monocatenary agro‐based surfactant, mono‐lactose 1,18‐octadec‐9‐enoate, was favoured with a molar ratio lactose/Acyl‐Cl of 1 achieving a yield of 48 % after 20 min. Moreover, production of bolaform agro‐based surfactant, di‐lactose 1,18‐octadec‐9‐enedioate, was favoured with a molar ratio of 3 lactose/Acyl‐Cl with a yield of 33 % after 1 h of reaction. A one‐pot synthesis of agro‐based bolaform surfactant was successfully achieved for the first time in the open literature. Monocatenary and bolaform agro‐based surfactants were isolated by preparative liquid chromatography with high purity according to their chemical structure identification by liquid chromatography coupled to mass spectrometry and 1H nuclear magnetic resonance. Their critical micellar concentration (12–9 μM) determined by fluorescence spectroscopy with pyrene used as a probe, and hydrophilic:lipophilic balance values (10.7–14.2) indicated that monocatenary and bolaform agro‐based surfactants can act as oils in water emulsion.

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Section: Resultsmentioning

confidence: 99%

Acylation of unprotected lactose with 1,18‐octadec‐9‐enedioyl chloride for the synthesis of monocatenary and bolaform agro‐based surfactants

et al. 2018

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“…Fourier transform infrared spectroscopy (FTIR) has been used for decades to investigate the structure and bonding of chemicals. It has many desirable features such as simple sample preparation, few sam-ples requirement, delivering reliable and fast results and being non-destructive (Banas et al, 2017;Özgenc et al, 2017). Currently, with the development of IR reflectance technique such as attenuated total re-flectance (ATR), FTIR is capable of directly measuring substances in solid (Banas et al, 2017) or liquid state (Zhang et al, 2017).…”

Section: Degradation Pathway Of 2-picolinic Acid By Strain Zd1mentioning

confidence: 99%

“…It has many desirable features such as simple sample preparation, few sam-ples requirement, delivering reliable and fast results and being non-destructive (Banas et al, 2017;Özgenc et al, 2017). Currently, with the development of IR reflectance technique such as attenuated total re-flectance (ATR), FTIR is capable of directly measuring substances in solid (Banas et al, 2017) or liquid state (Zhang et al, 2017). Therefore, the application of ATR-FTIR has been extended to many fields such as monitoring the solution concentration during a cooling crystallization process (Zhang et al, 2017), distinguishing 150 tablets with or without lactose (Banas et al, 2017), determining changes in the chemical structure of heat-treated woods (Özgenc et al, 2017), and exploring phosphate adsorption mechanisms at the ferrihydrite-water interface (Arai and Sparks, 2001).…”

Section: Degradation Pathway Of 2-picolinic Acid By Strain Zd1mentioning

confidence: 99%

Isolation of a 2-picolinic acid-assimilating bacterium and its proposed degradation pathway

Zheng

Wang

Yan-li

et al. 2017

Bioresource Technology

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Burkholderia sp. ZD1, aerobically utilizes 2-picolinic acid as a source of carbon, nitrogen and energy, was isolated. ZD1 completely degraded 2-picolinic acid when the initial concentrations ranged from 25 to 300mg/L. Specific growth rate (μ) and specific consumption rate (q) increased continually in the concentration range of 25-100mg/L, and then declined. Based on the Haldane model and Andrew's model, μ and q were calculated as 3.9 and 16.5h, respectively. Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) was used to determine the main intermediates in the degradation pathway. Moreover, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) was innovatively used to deduce the ring cleavage mechanism of N-heterocycle of 2-picolinic acid. To our knowledge, this is the first report on not only the utilization of 2-picolinic acid by a Burkholderia sp., but also applying FT-ICR-MS and ATR-FTIR for exploring the biodegradation pathway of organic compounds.

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“…Stands and tripods for laboratory imaging of small objects or calibration of sensors are usually used as moving platforms [9,10]. The potential for using similar hyperspectral sensors is huge, and examples can be found in geological analyses [11], analyses of ceramics and other archaeological artefacts [12,13,14,15,16], deep spectral analyses of works of art [17,18,19], environmental protection [20,21,22], precise agriculture [23,24], the pharmaceutical industry [25,26], medicine [27,28], construction [29] and many other branches of human activity.…”

Section: Introductionmentioning

confidence: 99%

Spatial Distortion Assessments of a Low-Cost Laboratory and Field Hyperspectral Imaging System

Krtalić

Miljković

Gajski

et al. 2019

Sensors

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This article describes the adaptation of an existing aerial hyperspectral imaging system in a low-cost setup for collecting hyperspectral data in laboratory and field environment and spatial distortion assessments. The imaging spectrometer system consists of an ImSpector V9 hyperspectral pushbroom scanner, PixelFly high performance digital CCD camera, and a subsystem for navigation, position determination and orientation of the system in space, a sensor bracket and control system. The main objective of the paper is to present the system, with all its limitations, and a spatial calibration method. The results of spatial calibration and calculation of modulation transfer function (MTF) are reported along with examples of images collected and potential uses in agronomy. The distortion value rises drastically at the edges of the image in the near-infrared segment, while the results of MTF calculation showed that the image sharpness was equal for the bands from the visible part of the spectrum, and approached Nyquist’s theory of digitalization. In the near-infrared part of the spectrum, the MTF values showed a less sharp decrease in comparison with the visible part. Preliminary image acquisition indicates that this hyperspectral system has potential in agronomic applications.

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Is it possible to find presence of lactose in pharmaceuticals? — Preliminary studies by ATR-FTIR spectroscopy and chemometrics

Cited by 18 publications

References 17 publications

Acylation of unprotected lactose with 1,18‐octadec‐9‐enedioyl chloride for the synthesis of monocatenary and bolaform agro‐based surfactants

Acylation of unprotected lactose with 1,18‐octadec‐9‐enedioyl chloride for the synthesis of monocatenary and bolaform agro‐based surfactants

Isolation of a 2-picolinic acid-assimilating bacterium and its proposed degradation pathway

Spatial Distortion Assessments of a Low-Cost Laboratory and Field Hyperspectral Imaging System

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