Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Solovieva, Anna B.; Vanin, Anatoly F.; Shekhter, Anatoly B.; Глаголев, Н. Н.; Aksenova, N. P.; Mikoyan, V. D.; Kotova, Svetlana; Fayzullin, Alexey; Timashev, Peter

doi:10.1016/j.niox.2018.12.004

Cited by 4 publications

(11 citation statements)

References 33 publications

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“…13 At the same time, the local delivery through direct injections of the wound bottoms promotes excessive trauma and hydration of wound tissues. 28,36 The spray form has the potential to become an effective way to The development of a simple, accessible and easy-to-use form of DNIC delivery has been a scientific challenge for many years. Shekhter et al synthesized a collagen-based scaffold containing 4 μM DNIC with a glutathione ligand, which facilitated wound regeneration and complete epithelialization 4 days earlier than in spontaneously healing wounds.…”

Section: Discussionmentioning

confidence: 99%

“…According to previously published studies, DNIC has beneficial effects on wound healing. 7 , 13 , 15 , 16 , 28 , 36 , 37 Nevertheless, intravenous drug administration for wound treatment is not justified due to the under-investigated side effects and pharmacokinetics. 13 At the same time, the local delivery through direct injections of the wound bottoms promotes excessive trauma and hydration of wound tissues.…”

Section: Discussionmentioning

confidence: 99%

“… 13 At the same time, the local delivery through direct injections of the wound bottoms promotes excessive trauma and hydration of wound tissues. 28 , 36 The spray form has the potential to become an effective way to apply DNIC for wound treatment in clinical practice, as it provides uniform distribution of the active substance and does not require expensive equipment for its synthesizing.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, in most studies, DNIC was delivered systemically by intravenous administration or by injections of the wound bottom, which is associated with systemic side-effects and prevents the translation of the results into clinical practice. 7 , 13 , 28 …”

Section: Introductionmentioning

confidence: 99%

“…administration or by injections of the wound bottom, which is associated with systemic side-effects and prevents the translation of the results into clinical practice. 7,13,28 Transdermal sprays and aerosols lack these limitations, making them attractive alternatives for DNIC delivery. They usually comprise a solution of active substance and volatile diluent.…”

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confidence: 99%

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Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Igrunkova¹,

Fayzullin²,

Churbanov³

et al. 2022

DDDT

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Background: Ditrosyl iron complexes (DNIC) are endogenous donors of nitric oxide. The possibility of their application to stimulate regeneration has been studied for more than 15 years. However, the most effective dose and form of delivery have not yet been determined. Purpose: The aim of this research was to develop a spray form of DNIC that accelerates wound healing. Methods: We prepared a series of DNIC sprays with spray dosages of 10, 50 and 100 μg. We modelled full-thickness skin wounds in 24 Wistar rats and treated them with distilled water (n = 6), 10 (n = 6), 50 (n = 6) and 100 μg (n = 6) for three post-operative days. On the fourth day, the excised wound tissues were studied by morphological, immunohistochemical and morphometric methods. Results: We demonstrated that 50 μg of DNIC spray had the most beneficial effect on wound healing: the thickness of the granulation tissue layer was 140% higher, vimentin positive fibroblasts predominated and the intensity of inflammation was significantly lower than in the control. There was a dose-dependent decrease in the functional activity of mast cells in the experimental groups compared to the control. Conclusion: DNIC spray is a potential effective dosage form for the treatment of large-area skin lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“… 13 At the same time, the local delivery through direct injections of the wound bottoms promotes excessive trauma and hydration of wound tissues. 28 , 36 The spray form has the potential to become an effective way to apply DNIC for wound treatment in clinical practice, as it provides uniform distribution of the active substance and does not require expensive equipment for its synthesizing.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Igrunkova¹,

Fayzullin²,

Churbanov³

et al. 2022

DDDT

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Comprehensive review of Pluronic® polymers of different shapes with prominent applications in photodynamic therapy

Kumar,

Harikrishnan,

Urmila

et al. 2023

European Polymer Journal

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The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

et al. 2021

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Nitric oxide (NO) is an important signaling molecule that is involved in a wide range of physiological and pathological events in biology. Metal coordination chemistry, especially with iron, is at the heart of many biological transformations involving NO. A series of heme proteins, nitric oxide synthases (NOS), soluble guanylate cyclase (sGC), and nitrophorins, are responsible for the biosynthesis, sensing, and transport of NO. Alternatively, NO can be generated from nitrite by heme- and copper-containing nitrite reductases (NIRs). The NO-bearing small molecules such as nitrosothiols and dinitrosyl iron complexes (DNICs) can serve as an alternative vehicle for NO storage and transport. Once NO is formed, the rich reaction chemistry of NO leads to a wide variety of biological activities including reduction of NO by heme or non-heme iron-containing NO reductases and protein post-translational modifications by DNICs. Much of our understanding of the reactivity of metal sites in biology with NO and the mechanisms of these transformations has come from the elucidation of the geometric and electronic structures and chemical reactivity of synthetic model systems, in synergy with biochemical and biophysical studies on the relevant proteins themselves. This review focuses on recent advancements from studies on proteins and model complexes that not only have improved our understanding of the biological roles of NO but also have provided foundations for biomedical research and for bio-inspired catalyst design in energy science.

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Is it possible to combine photodynamic therapy and application of dinitrosyl iron complexes in the wound treatment?

Cited by 4 publications

References 33 publications

Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Spray with Nitric Oxide Donor Accelerates Wound Healing: Potential Off-the-Shelf Solution for Therapy?

Comprehensive review of Pluronic® polymers of different shapes with prominent applications in photodynamic therapy

The Biologically Relevant Coordination Chemistry of Iron and Nitric Oxide: Electronic Structure and Reactivity

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