Is Ipsilateral Testis Mandatory for
the Occurrence of Contralateral
Intratesticular Biochemical
Changes Indicative of Hypoxia
after Unilateral Spermatic Cord
Torsion?

Akgür, Feza M.; Kılınç, Kamer; Aktuğ, Tanju

doi:10.1159/000475039

Cited by 20 publications

(14 citation statements)

References 14 publications

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“…Several studies showed that I/R injury is caused by oxygen free radicals [9,10] . On the other hand, the torsion of unilateral testis would induce bilateral injury [11,12] . The signal of ischemia may be transmitted from the affected side to the other with neuronal or humoral pathway [13] .…”

Section: Discussionmentioning

confidence: 99%

Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Sun¹,

Liu²,

Zhao³

et al. 2006

Urol Int

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Purpose: To study the influence of prepubertal unilateral testicular torsion on spermatogenesis postpubertally. Methods: Sixty prepubertal SD male rats were divided into 6 groups. In each group, animal suffered different courses of unilateral testicular torsion including sham operation, 2- and 6-hour-long torsion, and permanent torsion. Salvia miltiorrhiza was injected as a remedy to release the I/R injury in the 2- and 6-hour-long torted groups. Postpubertally, the percentage of DNA content of haploid cells in the testes was determined individually. Results: The percentage of haploid cells in the sham operation group was 76.5 ± 1.9%. The number decreased in every other group (p < 0.01). Comparing with the same course of torsion, Salvia miltiorrhiza injection could improve the percentage of haploid cells (p < 0.01). In the permanent unilateral testicular torted group, the percentage was nearly zero (0.4 ± 0.2%). Conclusions: Prepubertal unilateral testicular torsion induces decreased spermatogenesis postpubertally. The result takes place in the bilateral testes. Salvia miltiorrhiza, as an antioxidant remedy, could relieve the injury which manifests improved spermatogenesis.

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Section: Discussionmentioning

confidence: 99%

Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Sun¹,

Liu²,

Zhao³

et al. 2006

Urol Int

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show abstract

“…However, conflicting results are raised due to different animal species, such as rats or pigs, model of I/R injury, age, and technique that has been performed to evaluate the I/R damage[69]. Furthermore, several experimental studies proposed that the contralateral testis is not affected by unilateral torsion[70-72]. Nevertheless, there is evidence that both testes are affected, and contralateral testis is not disturbed by initial removal of the torsed testis and pretreatment with antioxidants[73-75].…”

Section: Searchmentioning

confidence: 99%

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

Vaos

Zavras

2017

WJM

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Testicular torsion (TT) is a medical emergency that primary affects newborns and young adolescents. It causes testicular injury due to the torsion of the spermatic cord and its components, initially in the venous blood flow and finally in the arterial blood flow. Prompt diagnosis and early surgical management are necessary in managing this urgent situation. The process of the pathophysiological events in ischemia-reperfusion is multifactorial and deals with the perception of the oxidative stress responsible for the consequences of ischemia/reperfusion (I/R) stress following TT. Duration and severity of torsion also play a significant role in the oxidative stress. A detrimental result of the defense system of the testes takes place resulting finally in testicular atrophy and impaired function. Antioxidant factors have been experimentally studied in an effort to front this state. They have been classified as endogenous or exogenous antioxidants. Endogenous antioxidants comprise a structure of enzymic enzymatic and non-enzymic enzymatic particles presented within cytoplasm and numerous other subunits in the cells. Exogenous antioxidants include a variety of natural and pharmaceutical agents that may prevent or ameliorate the harmful effects of I/R injury. In this study we review those factors and their ability to enhance the oxidative status of the testis. A feature insight into where we are heading is attempted.

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“…Those changes have been reversed, and fecundity has been improved by chemical sympathectomy prior to torsion [10,11]. Torsion of only epididymis and spermatic cord following subepididymal orchiectomy has shown that the elevation of indicators of tissue hypoxia in the contralateral testis and histological deterioration have not mandated the presence of ipsilateral testis [4,9].…”

Section: Introductionmentioning

confidence: 99%

Torsion of only spermatic cord in the absence of testis and/or epididymis results in contralateral testicular hypoxia

1997

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Unilateral spermatic cord torsion in the presence or absence of ipsilateral testis causes hypoxia in the contralateral testis. An experimental study was conducted to find the most important structure that causes contralateral testicular hypoxia following ipsilateral twisting. In five groups each consisting of 10 rats sham operations, epididymoorchiectomy, spermatic cord torsion, spermatic cord torsion following subepididymal orchiectomy or spermatic cord torsion following epididymoorchiectomy were performed. Lactic acid, hypoxanthine and thiobarbituric acid reactive products of lipid peroxidation (TBAR) were determined in the contralateral testis. While lactic acid, hypoxanthine and TBAR values did not differ significantly following sham and epididymoorchiectomy procedures, evaluation of other groups revealed significantly increased values compared with sham and epididymoorchiectomy groups. Since torsion of only spermatic cord and testicular vasculature causes contralateral testicular hypoxia, testis and epididymis do not seem to be mandatory for occurrence of contralateral testicular hypoxia. Testicular artery under distress seems to be the most important structure that results in contralateral testicular hypoxia following torsion.

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Is Ipsilateral Testis Mandatory for the Occurrence of Contralateral Intratesticular Biochemical Changes Indicative of Hypoxia after Unilateral Spermatic Cord Torsion?

Cited by 20 publications

References 14 publications

Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Long-Term Influence of Prepubertal Testicular Torsion on Spermatogenesis

Antioxidants in experimental ischemia-reperfusion injury of the testis: Where are we heading towards?

Torsion of only spermatic cord in the absence of testis and/or epididymis results in contralateral testicular hypoxia

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