Is Internal Timing Key to Mental Health?

Bhattacharjee, Yudhijit

doi:10.1126/science.317.5844.1488

Cited by 39 publications

(21 citation statements)

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“…Stable internal and external phase relationships seem crucial to a stable and euthymic mood state [56]. Chronobiology researchers have stressed the importance of timekeepers to stabilize phase, with light and melatonin being the most important.…”

Section: Chronotherapeutics In Bipolar Disordermentioning

confidence: 99%

Melatonin, circadian rhythms, and the clock genes in bipolar disorder

Dallaspezia

Benedetti

2009

Curr Psychiatry Rep

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Sleep disturbances and dysregulation of circadian rhythms are core elements of bipolar disorder that might be involved in its pathogenesis. It has been proposed that patients with bipolar disorder have an abnormally shifted or arrhythmic circadian system and that the disturbance of circadian rhythms may be caused by an alteration in the circadian clock machinery. Chronotherapeutic strategies based on controlled exposures to environmental stimuli that act on biological rhythms have shown good efficacy in the treatment of illness episodes, thus confirming ex juvantibus the clinical relevance of internal timing in this illness.

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Section: Chronotherapeutics In Bipolar Disordermentioning

confidence: 99%

Melatonin, circadian rhythms, and the clock genes in bipolar disorder

Dallaspezia

Benedetti

2009

Curr Psychiatry Rep

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“…There is also evidence that light/colour influences the function of the autonomic nervous system and hence that changes of colour perception have a biological basis (i.e. with genetic and phenotypic origins); and there is evidence that stress has pathological correlates [199].Such observations, supported by the existence of Grakov's Strannik technology (Strannik Virtual Scanning and Strannik Light Therapy) [167,200] illustrates that the brain employs frequency to regulate the body's function i.e. to modulate the function of the various physiological systems [201][202][203][204] e.g.…”

mentioning

confidence: 59%

“…Such observations, supported by the existence of Grakov's Strannik technology (Strannik Virtual Scanning and Strannik Light Therapy) [167,200] illustrates that the brain employs frequency to regulate the body's function i.e. to modulate the function of the various physiological systems [201][202][203][204] e.g.…”

Section: Summary/evidence Of a Mathematical Model Of The Autonomic Nementioning

confidence: 95%

The Framework of a Mathematical Model of the Autonomic Nervous System and Physiological Systems: Using the Neuroregulation of Blood Glucose as an Example

Ewing¹

2015

J Comput Sci Syst Biol

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IntroductionOur sense perception enables us to eat the correct amounts of food and, under normal circumstances, we cease eating when we have eaten sufficient food, and we drink sufficient to sati sfy the body 's need for liquid. We breathe at the normal expected rate, our heart pumps at the expected rate and maintain the normal level of blood pressure, our body maintains the normal levels of acidity and temperature, we sleep for 7-8 hours per night, etc. This suggests that the body is being regulated by a biological control mechanism of enormous sophistication and complexity, which has an enormous processing capacity; however as we age, and particularly as we age beyond 50 years, the mechanism which maintains our function become increasingly less able to sustain the levels of oxygen, blood glucose, blood cell content and a myriad of other biological components which the brain requires to function [1]. The i nnate g enetic c apacity o f key o rgans d eclines a nd r esults in shortages of proteins, hormones, etc. This h as a k nock-on e ffect affecting one biological sequence after another.The cumulative effect of our lifetime of experiences, due to environmental and biological factors, influences the function and/ or stability of the autonomic nervous system and ultimately the function of our DNA and genes [2]. The level of genetic expression of the proteins (genotype) which we require to sustain our function declines and the rate at which these expressed proteins subsequently react (phenotype) also declines i.e. the ability of the body to cope with extreme events declines.There are two fundamentally significant biological issues at play: (i) the genetic ability to express proteins (ii) the body's physiological demand i.e. the phenotype or influence of the environment. In the case of diabetes, in particular type 2 diabetes, this is the regulation of Blood Glucose. The greater the level of hyperglycaemia the greater is the associated demand for insulin. The development of a medical condition occurs when the environmental demand exceeds the body's innate capacity [3] i.e. the prevailing supply and/or level of insulin is insufficient to metabolise the excess of blood glucose. By contrast, the lower the level of hypoglycaemia, which occurs in type 1 diabetes, the lower is the demand/need for insulin. If there is insufficient blood glucose the excess of highly reactive insulin will seek an alternative substrate and ultimately results in damage to the peripheral blood vessels e.g. in particular to the brain, eyes, legs and feet.The evidence suggests that this regulatory process is performed by the brain via the process of neuroregulation [4][5][6]. This is a best-fit process which takes into account the prevailing state of development or physiological damage to a part of the brain, degeneration or damage to an organ (or limb), and the prevailing inter-cellular environment i.e. the feedback of biochemical signals from the viscera. AbstractDespite the immense advances of medical research there remains a fundamental theo...

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“…Takahashi, 2010). Circadian rhythm impairments occur in various disorders such as depression (Bhattacharjee, 2007), manic disorders (Yin et al, 2006), and sleep disorders (Toh et al, 2001). Patients with major depressive disorder (MDD) present with disruptions in biological circadian rhythms (Kronfeld-Schor and Einat, 2012); therefore, several investigations have suggested circadian rhythm disruption to be involved in the pathogenesis of MDD (Takahashi et al, 2008).…”

Section: Q2mentioning

confidence: 99%