Housing under abnormal light–dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice

Moriya, Shunpei; Tahara, Yu; Sasaki, Hiroyuki; Ishigooka, Jun; Shibata, Shigenobu

doi:10.1016/j.neures.2015.05.005

Cited by 9 publications

(8 citation statements)

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“…The circadian system has been implicated in emotional processes LeGates et al, 2014), which is supported by studies using animal models with deficiency in clock genes (Kondratova et al, 2010;De Bundel et al, 2013;Savalli et al, 2015a) or using aberrant lighting conditions (Fonken et al, 2009;Fonken et al, 2010;Bedrosian et al, 2011;Fonken et al, 2012;LeGates et al, 2012;Tapia-Osorio et al, 2013;Fonken and Nelson, 2013;Moriya et al, 2015). Especially, the importance of clock gene oscillations in the BLA has been demonstrated in mice showing depression-related behaviors (Savalli et al, 2015a).…”

Section: Discussionmentioning

confidence: 95%

“…Exposure to irregular LD cycles disrupts the time-keeping functions of the circadian system, which is often associated with detrimental health consequences, including mental health issues (Evans and Davidson, 2013; LeGates et al, 2014). It has been well documented in animal models that aberrant lighting conditions, such as shifted LD cycles, non-24-h LD schedules, constant light, or dim-light exposure at night, result in circadian disturbances as well as anxiety- or depression-like behaviors (Fonken et al, 2009; Fonken et al, 2010; Bedrosian et al, 2011; Fonken et al, 2012; LeGates et al, 2012; Tapia-Osorio et al, 2013; Fonken and Nelson, 2013; Moriya et al, 2015). In addition, human shift workers, who frequently experience nighttime illumination, have also been shown to have a higher risk of developing mood or anxiety disorders (Scott, 2000; Vogel et al, 2012; Morrissette, 2013; Caruso, 2014).…”

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confidence: 99%

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Chronic Light Exposure in the Middle of the Night Disturbs the Circadian System and Emotional Regulation

Ikeno

Yan

2016

J Biol Rhythms

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In mammals, the circadian system is composed of a principal circadian oscillator located in the suprachiasmatic nucleus (SCN) and a number of subordinate oscillators in extra-SCN brain regions and peripheral tissues/organs. However, how the time-keeping functions of this multiple oscillator circuit are affected by aberrant lighting environments remains largely unknown. In the present study, we investigated the effects of chronic light exposure in the middle of the night on the circadian system by comparing the mice housed in a 12:4:4:4-h L:DLD condition with the controls in 12:12-h L:D condition. Daily rhythms in locomotor activity were analyzed and the expression patterns of protein products of clock genes Period1 and Period2 (PER1 and PER2) were examined in the SCN and extra-SCN brain regions, including the dorsal striatum, hippocampus, paraventricular nucleus (PVN), and basolateral amygdala (BLA). Following 2 weeks of housing in the L:DLD condition, animals showed disturbed daily rhythms in locomotor activity and lacked daily rhythms of PER1 and PER2 in the SCN. In the extra-SCN brain regions, the PER1 and PER2 rhythms were affected in a region-specific pattern, such that they were relatively undisturbed in the striatum and hippocampus, phase-shifted in the BLA, and abolished in the PVN. In addition, mice in the L:DLD condition showed increased anxiety-like behaviors and reduced brain-derived neurotropic factor messenger RNA expression in the hippocampus, amygdala, and medial prefrontal cortex, which are brain regions that are involved in emotional regulation. These results indicate that nighttime light exposure leads to circadian disturbances not only by abolishing the circadian rhythms in the SCN but also by inducing misalignment among brain oscillators and negatively affects emotional processing. These observations serve to identify risks associated with decisions regarding lifestyle in our modern society.

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Section: Discussionmentioning

confidence: 95%

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confidence: 99%

Chronic Light Exposure in the Middle of the Night Disturbs the Circadian System and Emotional Regulation

Ikeno

Yan

2016

J Biol Rhythms

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“…In humans, misalignment of biological and social time might be a risk factor for developing depression 57 , and circadian rhythm anomalies have been observed in seasonal affective disorder, bipolar disorder, and other mood disorders 58 – 60 . One study revealed that mice under abnormal LD cycles showed arrhythmicity and damped clock gene expression rhythm in the hippocampus together with prolonged the FST immobility time 61 . We could monitor PER2::LUC expression rhythm in peripheral clocks and central clock, but not in the hippocampus, and observed a phase shift of peripheral clocks in only the NES-5 min group.…”

Section: Discussionmentioning

confidence: 99%

Night eating model shows time-specific depression-like behavior in the forced swimming test

Haraguchi

Fukuzawa

Iwami

et al. 2018

Sci Rep

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The circadian clock system is associated with feeding and mood. Patients with night eating syndrome (NES) delay their eating rhythm and their mood declines during the evening and night, manifesting as time-specific depression. Therefore, we hypothesized that the NES feeding pattern might cause time-specific depression. We established new NES model by restricted feeding with high-fat diet during the inactive period under normal-fat diet ad libitum. The FST (forced swimming test) immobility time in the NES model group was prolonged only after lights-on, corresponding to evening and early night for humans. We examined the effect of the NES feeding pattern on peripheral clocks using PER2::LUCIFERASE knock-in mice and an in vivo monitoring system. Caloric intake during the inactive period would shift the peripheral clock, and might be an important factor in causing the time-specific depression-like behavior. In the NES model group, synthesis of serotonin and norepinephrine were increased, but utilization and metabolism of these monoamines were decreased under stress. Desipramine shortened some mice’s FST immobility time in the NES model group. The present study suggests that the NES feeding pattern causes phase shift of peripheral clocks and malfunction of the monoamine system, which may contribute to the development of time-specific depression.

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“…Pattern differences in clock gene expression can be associated with a depressive state. Under abnormal light-dark conditions, Per1 and Per2 genes may result in a depressive state [95]. The expression of rPer1, rPer2, or rCry1 mRNA is similar in both young and old SCN; however, when stimulated by light, aging reduces the gene expression [89].…”

Section: Effects Of Per and Cry On The Aging Processmentioning

confidence: 99%

Circadian Clock Gene Regulation in Aging and Drug Discovery

Li¹,

Dang²,

Ling³

et al. 2016

Molecular Mechanisms of the Aging Process and Rejuvenation

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The circadian clock is an endogenous timer in prokaryotes and mammals. Resting and adjusting the internal clock can assist in pacing the daily routine. Growing evidence indicates that the circadian clock and aging process are closely associated. The disruption of the circadian clock leads to accelerated aging and increased incidence of various diseases. In particular, elderly people are more vulnerable and have a higher risk of diseases than do young people. In this study, we reviewed studies on aging and circadian rhythms over the last decade, with a focus on circadian clock gene regulation in aging and drug discovery for targeting the circadian clock in diseases.

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Housing under abnormal light–dark cycles attenuates day/night expression rhythms of the clock genes Per1, Per2, and Bmal1 in the amygdala and hippocampus of mice

Cited by 9 publications

References 29 publications

Chronic Light Exposure in the Middle of the Night Disturbs the Circadian System and Emotional Regulation

Chronic Light Exposure in the Middle of the Night Disturbs the Circadian System and Emotional Regulation

Night eating model shows time-specific depression-like behavior in the forced swimming test

Circadian Clock Gene Regulation in Aging and Drug Discovery

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