Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?

Cengiz, Mustafa; Candır, Burcu Aslan; Yılmaz, Güldal; Akyol, Gülen; Özeni̇rler, Seren

doi:10.3748/wjg.v19.i42.7412

Cited by 37 publications

(36 citation statements)

References 28 publications

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“…There has been evidence that the RDW may predict mortality in newly hospitalised patients, critically ill patients and in older community patients [4,[22][23][24][25], with RDW also a marker of diabetes in the elderly through a HbA1c association [26]. Increased RDW also may be a useful marker for the assessment of liver function, with associations noted for both non-alcoholic steatohepatitis and fibrosis [27], and HBV induced liver cirrhosis [28]. Underpinning RDW associations with the diverse array of disease is a likely link to increased inflammation [3,29] and disrupted erythropoiesis.…”

Section: Discussionmentioning

confidence: 99%

The early detection of anaemia and aetiology prediction through the modelling of red cell distribution width (RDW) in cross-sectional community patient data

Badrick¹,

Arnott

Lidbury³

2015

Diagnosis

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Background: Red cell distribution width (RDW) is a marker of iron-deficient anaemia that can also assist differentiation of other anaemias. RDW also has been suggested as an effective marker for earlier anaemia detection. The RDW-anaemia relationship was investigated in cross-sectional community patient data, and the capacity of RDW to predict the diagnostic value of second tier anaemia markers assessed. Methods: Routine and second tier assay data were provided by the laboratory Sullivan Nicolaides Pathology. The cohort was divided into male and female groups stratified by age, and correlation analyses assessed associations of RDW to haemoglobin and ferritin. Analysis of covariance (ANCOVA) was performed for both routine and second tier markers to investigate their significance for RDW prediction.

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Section: Discussionmentioning

confidence: 99%

The early detection of anaemia and aetiology prediction through the modelling of red cell distribution width (RDW) in cross-sectional community patient data

Badrick¹,

Arnott

Lidbury³

2015

Diagnosis

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“…These scores consist of easily available and applicable variables, such as aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AAR), AST to platelet ratio index (APRI), fibrosis index (FI), fibrosis cirrhosis index (FCI), and fibrosis 4 (FIB‐4) score . As there is a growing necessity of non‐invasive markers in predicting fibrosis, various markers have been reported to be associated with liver fibrosis, although there is a clear lack in this field …”

Section: Introductionmentioning

confidence: 99%

Role of serum toll‐like receptors 2 and 4 in non‐alcoholic steatohepatitis and liver fibrosis

Cengiz¹,

Özeni̇rler

Elbeğ

2015

J of Gastro and Hepatol

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“…Elevated RDW has been reported to associate with higher mortality risk among the general population (39). Cengiz et al (40) have also reported a positive correlation between RDW values and fibrotic scores in patients with NASH. Hu et al (41) have observed that RDW increased in chronic patients with CHB and have suggested that RDW may serve as a potential prognostic index in liver disease.…”

Section: Discussionmentioning

confidence: 86%

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Nar¹,

Sezgin²

2016

vhd

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ÖZObjective: Liver biopsy, as well as some non-invasive biochemical parameters are also used in monitoring patients with chronic hepatitis C (CHC). The aim of this study was to investigate the relationship between serum biochemical markers and HCV RNA titers in patients with previously untreated CHC. Materials and Methods:We performed a retrospective study on anti-HCV and HCV-RNA-positive 82 patients with CHC. Eighty two healthy subjects constituted the control group. Complete blood counts, total protein (TP), albumin (ALB), C-reactive protein (CRP), γ-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and HCV RNA levels were recorded for each patient and control subject. Neutrophil-lymphocytes ratio (NLR) and the fibrosis index based on the 4 factors (FIB-4 index) were calculated using formulas.Results: There was a significant difference in ALT, AST, GGT, TP , CRP , red cell distribution width (RDW), lymphocytes (LYM), platelets (PLT), FIB-4, and NLR between CHC patients and controls (p=<0.05

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Is increased red cell distribution width an indicating marker of nonalcoholic steatohepatitis and fibrotic stage?

Abstract: RDW a new non-invasive marker that can be used to demonstrate the presence of NASH and indicate advanced fibrotic scores.

Cited by 37 publications

References 28 publications

The early detection of anaemia and aetiology prediction through the modelling of red cell distribution width (RDW) in cross-sectional community patient data

The early detection of anaemia and aetiology prediction through the modelling of red cell distribution width (RDW) in cross-sectional community patient data

Role of serum toll‐like receptors 2 and 4 in non‐alcoholic steatohepatitis and liver fibrosis

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

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