Is <i>Helicobacter pylori</i> associated with Behçet's syndrome? A meta‐analysis

Yu, Yong; Yao, Xin; Liang, Junyu; Lü, Chao; Yan, Tang; Lin, Jin

doi:10.1111/hel.12663

Cited by 15 publications

(6 citation statements)

References 32 publications

(58 reference statements)

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“…Moreover, in a small cohort of patients with BD, a significant improvement in the number and size of oral and genital ulcers was observed after H pylori eradication 89 . These findings were confirmed in a recent meta‐analysis, reporting that BD patients were more susceptible to H pylori infection, with an OR of 1.39 (95% CI, 1.03‐1.87) 90 …”

Section: Immune‐mediated Diseasesmentioning

confidence: 61%

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Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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The involvement of Helicobacter pylori infection in many extra‐gastroduodenal manifestations remains a fascinating field of investigation. However, for several of these supposed associations, the potential pathogenic mechanism remains unclear. The present review highlights the main associations of H pylori with extra‐gastroduodenal manifestations reported during the last year. We searched for the most relevant studies on this topic, published between April 2019 and March 2020, identified using the term “Helicobacter” in the MEDLINE/Pubmed database. Consistent data emerged from studies investigating metabolic syndrome and ischaemic cardiovascular diseases. Other reported fields of investigation were hepatology, especially focused on non‐alcoholic steatohepatitis, neurology, including Parkinson’s disease and Alzheimer’s disease, as well as dermatology. Inflammatory bowel disease (IBD), that comprises Crohn’s disease and ulcerative colitis, may originate from a dysregulation of the host’s immune response to commensal bacteria in individuals with genetic predisposition. The reduction of biodiversity and other specific imbalances in the faecal microbiome composition of IBD patients compared to that of healthy controls support this hypothesis. In this context, an inverse correlation between H pylori infection and IBD prevalence has been confirmed. Similar results were found in patients with kidney diseases and allergic manifestations. There are indications of the possible involvement of H pylori infection in metabolic syndrome and ischaemic cardiovascular diseases. However, due to a series of factors linked to study designs and the multifactorial pathogenesis of some diseases, further studies are needed.

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Section: Immune‐mediated Diseasesmentioning

confidence: 61%

“…89 These findings were confirmed in a recent meta-analysis, reporting that BD patients were more susceptible to H pylori infection, with an OR of 1.39 (95% CI, 1.03-1.87). 90…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Review: Extragastric diseases andHelicobacter pylori

et al. 2020

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“…There was also a strong correlation between H. pylori infection and halitosis, but the mechanism was not clear as it was difficult to determine whether the halitosis was induced by H. pylori in the stomach or caused by the changes of oral microflora induced by H. pylori infection ( Anbari et al., 2019 ). A study analyzed the correlation between Behçet’s syndrome (BS) and H. pylori infection and found that BS patients had a higher rate of H. pylori infection, and the clinical symptoms including oral ulceration, genital ulceration, and cutaneous lesions could be improved after H. pylori eradication ( Yu et al., 2019 ). However, its specific mechanism remains to be explored.…”

Section: Helicobacter Pylori and Oral Microbiomementioning

confidence: 99%

The interactions between oral-gut axis microbiota and Helicobacter pylori

Chen

Wang

et al. 2022

Front. Cell. Infect. Microbiol.

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In the human body, each microbial habitat exhibits a different microbial population pattern, and these distinctive microflorae are highly related to the development of diseases. The microbial interactions from host different niches are becoming crucial regulators to shape the microbiota and their physiological or pathological functions. The oral cavity and gut are the most complex and interdependent microbial habitats. Helicobacter pylori is one of the most important pathogens from digestive tract, especially the stomach, due to its direct relationships with many gastric diseases including gastric cancer. H. pylori infections can destroy the normal gastric environment and make the stomach a livable channel to enhance the microbial interactions between oral cavity and gut, thus reshaping the oral and gut microbiomes. H. pylori can be also detected in the oral and gut, while the interaction between the oral-gut axis microbiota and H. pylori plays a major role in H. pylori’s colonization, infection, and pathogenicity. Both the infection and eradication of H. pylori and its interaction with oral-gut axis microbiota can alter the balance of the microecology of the oral-gut axis, which can affect the occurrence and progress of related diseases. The shift of oral-gut axis microbiota and their interactions with H. pylori maybe potential targets for H. pylori infectious diagnosis and treatment.

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“…Several investigations have tried to identify key pathogenetic mechanisms suggesting the microorganism as a systemic pathogen [14]. Specifically, the remodeling of the host's immune response, enabling H. pylori to escape early clearance and promoting its survival in the host environment, may enhance, as a side effect, the risk of developing organ-specific autoimmune manifestations such as Behçet disease [15], type-1 diabetes mellitus [16], rheumatic disorders [17], and systemic lupus erythematosus [18], to mention a few [19]. In particular, H. pylori has been implicated in autoimmune thyroid disorders (AITDs) [20] as well as in a number of non-autoimmune TDs.…”

Section: Introductionmentioning

confidence: 99%

Association of Helicobacter pylori Infection with Autoimmune Thyroid Disease in the Female Sex

Dore

Fanciulli

Manca

et al. 2023

JCM

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Background. Helicobacter pylori infection has been associated with an increased risk of thyroid diseases (TDs), although scientific evidence is conflicting. In the present study the relationship between TDs, including both autoimmune (AI) and non-autoimmune TD, and H. pylori infection was investigated. Methods: Data from records of patients undergoing upper endoscopy and histologically evaluated for H. pylori infection were retrieved. In addition to demographic information, the features of gastritis based on non-targeted biopsies collected from the antrum, angulus, and corpus were analyzed. The presence of H. pylori infection and atrophy and/or metaplasia and/or dysplasia in at least one gastric specimen was defined as a long-lasting H. pylori infection and the presence of a chronic–active gastritis as a current infection. Hashimoto’s and Graves’ diseases were included in the AITD group, and thyroid nodules, goiter, iatrogenic thyroid hypo/hyper function, and thyroidectomy in the non-autoimmune TD group. Results: A total of 8322 records from adult patients from Northern Sardinia, characterized by a similar genetic background, was analyzed. Participants were aged 18–93 years (females 5339, 64.1%), and more specifically, 562 (6.7%) had a diagnosis of AITD and 448 (5.4%) of non-autoimmune TD. A significant association between long-lasting H. pylori and AITD (OR 1.34; 95%CI 1.13–1.60) was found, irrespective of age, sex, body mass index, and smoking status, while it was not associated with non-autoimmune TD. Current H. pylori infection did not show significant ORs for AITD (OR 0.99; 95%CI 0.64–1.57) and non-autoimmune TD (OR 0.86; 95%CI 0.66–1.15). The association with long-lasting H. pylori infection was confirmed to be significant for both Hashimoto’s thyroiditis and Graves’ disease by multivariable regression analysis. Stratification according to sex revealed a significant association only for females (OR 1.39; 95%CI 1.12–1.72). Conclusions. Our results indicate that long-lasting H. pylori infection is associated with AITD in the female adult population of Northern Sardinia.

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Is Helicobacter pylori associated with Behçet's syndrome? A meta‐analysis

Cited by 15 publications

References 32 publications

Review: Extragastric diseases andHelicobacter pylori

Review: Extragastric diseases andHelicobacter pylori

The interactions between oral-gut axis microbiota and Helicobacter pylori

Association of Helicobacter pylori Infection with Autoimmune Thyroid Disease in the Female Sex

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