Is Human Papillomavirus and Helicobacter pylori Related in Gastric Lesions?

Bozdayı, Gülendam; Dinç, Bedia; Avcıküçük, Havva; Turhan, Nesrin; Altay-Kocak, Aylin; Özkan, Seçil; Özın, Yasemin; Bostancı, Birol

doi:10.7754/clin.lab.2019.181244

Cited by 10 publications

(6 citation statements)

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“…Fourteen studies investigated the prevalence of HPV including 901 patients with GC and 1,205 any controls ( 11 – 14 , 22 , 25 , 31 , 39 , 43 , 46 , 49 , 50 , 53 , 54 ). The pooled HPV prevalence in GC was 23.6% (95% CI 15.5%–31.6%, random model, heterogeneity P < 0.001).…”

Section: Resultsmentioning

confidence: 99%

“…Association between HPV infection and the risk of GC was observed (OR = 1.53, 95% CI 1.00–2.33, random model, heterogeneity P = 0.002) (see Figure 1c, Supplementary Digital Content 1, http://links.lww.com/CTG/A299 ). Five studies investigated the coinfection of H. pylori or EBV without extractable data for cases and controls ( 12 , 13 , 49 , 53 , 54 ). We reanalyzed after excluding controls with H. pylori -positive gastritis in the study by Bozdayi et al, and association still existed (OR = 1.63, 95% CI 1.05–2.54, random model, heterogeneity P = 0.002) (Figure 2 c) ( 53 ).…”

Section: Resultsmentioning

confidence: 99%

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Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Wang

Chen

et al. 2020

Clinical and Translational Gastroenterology

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INTRODUCTION: Besides Helicobacter pylori and Epstein-Barr virus, other viruses might play potential roles in gastric carcinogenesis. This systematic review and meta-analysis was conducted to compare the prevalence of the viruses between gastric cancer (GC) and any controls. METHODS: Comprehensive literature was searched up to January 25, 2019, and search was updated on April 6, 2020. The studies that compared the prevalence of viruses other than Epstein-Barr virus between GC and healthy or nonmalignant controls were eligible. Stata 12.0 software was used for heterogeneity tests and meta-analyses. Meanwhile, subgroup analysis, sensitivity analysis, and publication bias evaluation were performed where applicable. The power (1–β) was estimated by the PASS 11 software for each individual study. RESULTS: A total of 41 eligible studies were included, concerning 11 kinds of viruses. Prevalence were significantly higher in GC for hepatitis B virus (odds ratio [OR] = 1.39, 95% confidence interval [CI] 1.11–1.75), human cytomegalovirus (OR = 2.25, 95% CI 1.14–4.43), human papillomavirus (HPV) (OR = 1.63, 95% CI 1.05–2.54), and John Cunningham virus (OR = 2.52, 95% CI 1.26–5.04). In subgroup analyses, HPV-16 infection was significantly associated with GC (OR = 2.42, 95% CI 1.00–5.83). DISCUSSION: This study demonstrated that hepatitis B virus, human cytomegalovirus, HPV, and John Cunningham virus were more prevalent in GC. However, the causal relationship between their infection and risk of GC remains inconclusive, and further investigations are required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Wang

Chen

et al. 2020

Clinical and Translational Gastroenterology

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“…Currently, involvement of human papillomaviruses (HPV) in gastric tumorigenesis remains to be controversial and requires further investigation. While some studies suggested a potential link between HPV infection and gastric tumor, and also reported the presence of high-risk carcinogenic HPVs in GC and gastritis tissues [ 239 , 240 ], other studies did not found such associations [ 241 , 242 ].…”

Section: Other Carcinogenic Virusesmentioning

confidence: 99%

Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis

Palrasu

Zaika

El-Rifai

et al. 2021

Cancers

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Gastric cancer (GC) is one of the deadliest malignancies worldwide. In contrast to many other tumor types, gastric carcinogenesis is tightly linked to infectious events. Infections with Helicobacter pylori (H. pylori) bacterium and Epstein–Barr virus (EBV) are the two most investigated risk factors for GC. These pathogens infect more than half of the world’s population. Fortunately, only a small fraction of infected individuals develops GC, suggesting high complexity of tumorigenic processes in the human stomach. Recent studies suggest that the multifaceted interplay between microbial, environmental, and host genetic factors underlies gastric tumorigenesis. Many aspects of these interactions still remain unclear. In this review, we update on recent discoveries, focusing on the roles of various gastric pathogens and gastric microbiome in tumorigenesis.

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“…One recent study identified 38% of positive results for HPV in samples from patients with GC and 41.8% in cases of gastritis. Similarly, they showed an association between HPV and Helicobacter Pylori in gastritis (Bozdayi et al, 2019). These results could lead to new studies in order to clarify the role of HPV in the carcinogenesis of such tumours.…”

Section: Hpv and Its Association With Digestive Tract Cancersmentioning

confidence: 76%

The current outlook of human papillomavirus and its association with digestive tract cancer

Urrego

Arango

et al. 2020

RLCT

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Digestive tract cancers are frequent worldwide, despite efforts to control known predisposing factors, they keep increasing, this fact suggests that human papillomavirus (HPV) may play an important oncogenic role in these pathologies. In order to argue the incidence that HPV has in the genesis of gastrointestinal tract tumors and to determine if it is a possible causal agent, the scientific literature published to date on the subject was reviewed, and was found that 4.5% of all diagnosed cancers correspond to HPV; 12% are extra cervical, 20% esophagus, 31.9% colon adenomas, 43% colorectal adenocarcinoma, and 35% head and neck neoplasms (HNSCC). The types of HPV reported in the digestive tract are 6, 9, 11, 13, 16.18, 20, 24, 25, 30, 33, 51, 54, 57, DL 416, DL 428 and DL 436. Although, the studies show the HPV impact in the oncogenesis and its role as a prognostic marker in some of them, they do not have hard evidence that reveals this relationship, therefore demonstrating its integration would allow clarifying it.

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Is Human Papillomavirus and Helicobacter pylori Related in Gastric Lesions?

Cited by 10 publications

References 0 publications

Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Associations Between Gastric Cancer Risk and Virus Infection Other Than Epstein-Barr Virus: A Systematic Review and Meta-analysis Based on Epidemiological Studies

Role of Bacterial and Viral Pathogens in Gastric Carcinogenesis

The current outlook of human papillomavirus and its association with digestive tract cancer

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