Is human cytomegalovirus infection associated with essential hypertension? A meta‐analysis of 11,878 participants

Wang, Zuoguang; Peng, Xiaobo; Li, Mei; Jin, Fei; Zhang, Bei; Wang, Hao; Wei, Yongxiang

doi:10.1002/jmv.24391

Cited by 7 publications

(3 citation statements)

References 40 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In view of the important role of CMV in the pathogenesis of PSS [3,4], CMV-IgG and CMV-IgM were further detected in all PSS patients and controls by indirect ELISA. However, since a history of ophthalmic CMV infection had been excluded from both PSS patients and controls by examining their previous medical records, the CMV infection rates of PSS patients and controls were lower than expected in the general population [17]. …”

Section: Discussionmentioning

confidence: 99%

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

et al. 2017

View full text Add to dashboard Cite

Posner-Schlossman syndrome (PSS) shares some clinical features with uveitis and open angle glaucoma. Cytokines and autoantibodies have been associated with uveitis and open angle glaucoma. However, the role of serum cytokines and autoantibodies in the pathogenesis of PSS remains unknown. This study aimed to evaluate the associations of type 1 T helper (Th1) and Th17 related cytokines and autoantibodies with PSS. Peripheral blood serum samples were collected from 81 patients with PSS and 97 gender- and age-matched healthy blood donors. Th1 and Th17 related cytokines, including interleukin-1β (IL-1β), IL-12, tumor necrosis factor-α (TNF-α), interferon- γ (IFN-γ), IL-6 and IL-17, and glucose-6-phosphate isomerase (GPI) were determined by double antibody sandwich ELISA. Anti-nuclear antibody (ANA), anti-keratin antibody (AKA) and anti-neutrophil cytoplasmic antibody (ANCA) were detected by indirect immunofluorescence assay. Anti-cardiolipin antibody (ACA)-IgG, ACA-IgM, ACA-IgA, anti-double stranded DNA (anti-dsDNA) and anti-cyclic citrullinated peptide antibody (anti-CCP) were detected by indirect ELISA. Serum levels of IL-1β, IL-12 and IL-6 in PSS patients were significantly lower than those in controls (P < 0.003), and these associations survived the Bonferroni correction (Pc < 0.018). There was no significant difference in serum levels of TNF-α, IFN-γ and IL-17 between the PSS and control groups (Pc > 0.12). Positive rate of serum anti-dsDNA in PSS patients was significantly higher than that in the control group (P = 0.002, Pc = 0.018), while positive rates of serum ANA, AKA, ANCA, ACA-IgG, ACA-IgM, ACA-IgA, GPI and anti-CCP in the PSS group were not significantly different from those in the control group (Pc > 0.09). These results suggest that anti-dsDNA may contribute to the pathogenesis of PSS, while Th1 and Th17 related cytokines and other autoantibodies may not be major contributors to PSS.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

et al. 2017

View full text Add to dashboard Cite

show abstract

“…While a number of other infections, such as Aggregatibacter, Prevotella [33], Helicobacter pylori [34], HIV [35–37], herpes simplex virus-2 [38], cytomegalovirus [39], Toxoplasmosis gondii [40] have been shown to be associated with an increased risk of hypertension, there are no prior studies which assessed the outcome of these infections in the hypertensive patients. In our study, the proportion of patients who had sputum AFB smear positivity and cavitary disease at the time of diagnosis was higher in the non-hypertensive group compared to the hypertensive group, suggesting a higher bacillary burden in the lungs of patients in the former group.…”

Section: Discussionmentioning

confidence: 99%

The impact of hypertension and use of calcium channel blockers on tuberculosis treatment outcomes

Chidambaram¹,

Gupte

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Hypertension induces systemic inflammation, but its impact on the outcome of infectious diseases like tuberculosis (TB) is unknown. Calcium channel blockers (CCB) improve TB treatment outcomes in pre-clinical models, but their effect in patients with TB remain unclear. Methods: This retrospective cohort study, including all patients > 18 years receiving treatment for culture-confirmed, drug-sensitive TB from 2000 to 2016 at the National Taiwan University Hospital, assessed the association of hypertension and CCB use with all-cause and infection-related mortality during the first 9 months of TB treatment, as well as sputum-smear microscopy and sputum-culture positivity at 2 and 6 months. Results: 1052 of the 2894 patients (36.4%) had hypertension. Multivariable analysis revealed that hypertension was associated with increased mortality due to all causes (HR 1.57, 95% confidence interval[CI], 1.23-1.99) and infections (HR 1.87, 95%CI, 1.34-2.6), but there was no statistical difference in microbiological outcomes when stratified based on hypertensive group. Dihydropyridine-CCB (DHP-CCB) use was associated with reduced all-cause mortality (HR 0.67, 95%CI: 0.45-0.98) only by univariate Cox regression. There was no association between DHP-CCB use and infection-related mortality (HR 0.78, 95%CI: 0.46-1.34) or microbiological outcomes in univariate or multivariate regression analyses. Conclusions: Patients with hypertension have increased all-cause mortality and infection-related mortality during the 9 months following TB treatment initiation. DHP-CCB use may lower all-cause mortality in TB patients with hypertension. The presence of hypertension or the use of CCB did not result in a significant change in microbiological outcomes. Keywords: Tuberculosis, hypertension, calcium channel blockers, mortality, treatment outcomes

show abstract

“…CMV infection has also been associated with an increased risk of atherosclerosis, 3 essential hypertension 4 and cardiovascular diseases (CVDs) in the overall population. 5 CVDs are one of the main causes of death with a functioning graft in kidney transplant recipients.…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus Disease, Short-Term Cardiovascular Events and Graft Survival in a Cohort of Kidney Transplant Recipients With High CMV IgG Seroprevalence

Díaz

Jaimes

2021

Prog Transpl

View full text Add to dashboard Cite

Introduction: Both cytomegalovirus (CMV) infection and CMV disease have been linked with several long-term indirect effects in kidney transplant recipients. Research questions: We conducted a retrospective study to assess the association between cytomegalovirus disease and risks of death, shortterm cardiovascular events and graft loss in a cohort of renal transplant recipients. Design: The associations between CMV disease and death and cardiovascular events were determined using Cox regression models, while the association between viral disease and graft loss risk was analyzed through a competing risks regression according to the Fine and Gray method. Death with a functioning graft was considered as a competing risk event. Results: A total of 865 consecutive renal transplant recipients were included. The prevalence of seropositive donor/seronegative recipient (D+/R-) group was 89.9% with the remaining patients classified as seropositive recipient (R+). After median follow-up time of 24.4 months, CMV disease was not a risk factor for all-causes mortality (HR = 1.75; 95% CI 0.94-3.25), early cardiovascular events (HR = 0.54; 95% CI 0.16-1.82) or graft loss (subhazard ratio [the HR adjusted for competing risk of death with functioning graft] = 0.99; 95% CI 0.53-1.84). Conclusions: In this cohort with high prevalence of CMV IgG antibodies, we found no association between cytomegalovirus disease and risk of death or graft loss. The relationship between CMV and cardiovascular disease remains to be unraveled and probably corresponds to a multifactorial phenomenon involving individual risk factors and the immune response to infection rather than the virus effect itself.

show abstract

Is human cytomegalovirus infection associated with essential hypertension? A meta‐analysis of 11,878 participants

Cited by 7 publications

References 40 publications

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

Serum Th1 and Th17 related cytokines and autoantibodies in patients with Posner-Schlossman syndrome

The impact of hypertension and use of calcium channel blockers on tuberculosis treatment outcomes

Cytomegalovirus Disease, Short-Term Cardiovascular Events and Graft Survival in a Cohort of Kidney Transplant Recipients With High CMV IgG Seroprevalence

Contact Info

Product

Resources

About