Is hormone therapy during climacteric for all?

Sintomas Psicológicos Em Mulheres Climatéricas Cardiopatas

“…Essa fase de declínio estrogênico aumenta o risco cardiovascular nas mulheres, constituindo a maior causa de morte em países desenvolvidos e em desenvolvimento (6) . Além disso, existe uma preocupação a respeito dos efeitos da terapia de reposição hormonal (TRH) em mulheres climatéricas sobre o risco maior de desenvolver um evento coronariano (7)(8) .…”

Breast cancer survivals and hormone therapy: estrogen and melatonin

“…Although many women go through this age phase without any symptoms or significant challenges, others suffer with intense vasomotor symptoms (hot flashes), which can cause perspiration and interfere with sleep if they occur at night 1 . Also, approximately 80% of breast cancer patients are above 50 years old, which matches with the mean age of menopause 1 , 2 . However, the behavior and prognosis of this malign neoplasia may be related to the estrogen status 3 .…”

“…Some breast cancer survivors experience hot flashes without improvement when treated by the non-hormonal drugs, mainly serotonin reuptake inhibitors, as well as the inhibitors of reuptake of noradrenaline and serotonin and other substances 9 . It is a great concern to alleviate these symptoms, which affect sleep patterns, professional activities, and quality of life 1 , 2 . The hormone therapy with estrogen is a controversial question: it decreases the symptoms, but may impact the prognosis of the patient 1 - 3 , 8 .…”

“…It is a great concern to alleviate these symptoms, which affect sleep patterns, professional activities, and quality of life 1 , 2 . The hormone therapy with estrogen is a controversial question: it decreases the symptoms, but may impact the prognosis of the patient 1 - 3 , 8 . The HABITS trial showed 2.4 times more risk of new breast cancer events in breast cancer survivors with a cumulative incidence of 22.2% in the group taking hormone replacement versus 8% in the control arm at 5 years 10 .…”

May isoflavones prevent breast cancer risk?

“…However, the risk of breast cancer needs to be better explored and evaluated, mainly in the long term, and there are still risks that should be better evaluated, such as metabolic ones. In addition, the indication of isoflavone extracts should be individualized, as estroprogestative hormone therapy in the climacteric 26 , guiding the patient on the benefits and risks, as well as respecting the individual preferences of postmenopausal women until new evidences in the literature.…”