Is gingival bleeding a symptom of patients with type 1 von <scp>W</scp>illebrand disease? A case–control study

Weickert, Lisa; Miesbach, Wolfgang; Alesci, S.; Eickholz, Peter; Nickles, Katrin

doi:10.1111/jcpe.12274

Cited by 10 publications

(29 citation statements)

References 21 publications

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“…The characteristics of the patients and controls are shown in Table 1 [14]. Both groups were well balanced in terms of sex, age, nicotine consumption (self-reported and assessed by CO in exhaled breaths), number of remaining teeth, and periodontal diagnosis.…”

Section: Resultsmentioning

confidence: 99%

“…The participants were classified as smokers if they reported current smoking or had quit smoking less than 5 years prior to the study [16]. Additionally, the amount of carbon monoxide (CO) in their exhaled breath was measured using a Smokerlyzer (Bedfont Smokerlyzer EC50-Micro; Bedfont Scientific Ltd, Rochester, UK) [14].…”

Section: Data Collectionmentioning

confidence: 99%

“…All of the other parameters were control variables. In each group, the means and standard deviations were calculated for GBI, BOP, age, number of remaining teeth, exhaled CO, VWF:Ag, VWF:RCo, and FVIII:c. The significance of between-group differences was calculated using x 2 tests or Fisher's exact test, with a significance level of P < 0.05 (based on assumptions described elsewhere) [14].…”

Section: Data Collectionmentioning

confidence: 99%

“…Periodontal examinations for gingival bleeding were performed at the Department of Periodontology as described elsewhere [14]. The evaluation used the GBI to assess inflammation in the marginal area of the gingiva; BOP was performed to assess subgingival inflammation.…”

Section: Data Collectionmentioning

confidence: 99%

“…Existing VWD case reports describing spontaneous gingival bleeding as a symptom did not investigate periodontal health in detail [12,13]. A recent study by Weickert et al [14] measured periodontal parameters to verify the source of oral bleeding in type 1 VWD patients compared with controls and chose gingival bleeding index (GBI) and bleeding on probing (BOP) as the outcome parameters to compare gingival bleeding in both study groups [15]. In the current study, we analyse and describe the questionnaire characteristics and haematological backgrounds of these respective patients with mild type 1 VWD and controls.…”

Section: Introductionmentioning

confidence: 96%

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Gingival bleeding and mild type 1 von Willebrand disease

Weickert

Krekeler

Nickles

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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Oral bleeding is a frequently reported symptom of von Willebrand disease (VWD) and evaluated by several VWD bleeding scores. Gingival bleeding is also known to be a leading symptom of plaque-induced gingivitis and untreated periodontal disease. This study evaluates whether mild type 1 VWD is associated with an increased susceptibility to gingival bleeding. In this case-control study, 50 patients and 40 matched controls were periodontally examined, answered a questionnaire, and underwent professional teeth cleaning. Compared with the controls, the VWD patients more frequently reported periodontal symptoms, such as bleeding (34 vs. 20%, P = 0.141) and swelling (54 vs. 32.5%, P = 0.538) of the gingiva, and these patients had their teeth professionally cleaned less often (58 vs. 77.5%, P = 0.051). However, there was less gingival bleeding, as determined by the gingival bleeding index, in the VWD patients compared with the controls (10 vs. 12.2%, P = 0.047); the amount of bleeding on probing was similar between the VWD patients and the controls (17 vs. 17.2%, P = 0.723). Gingival bleeding in VWD patients may be triggered by gingival inflammation, but it is not a genuine symptom of mild type 1 VWD.

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Section: Resultsmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Gingival bleeding and mild type 1 von Willebrand disease

Weickert

Krekeler

Nickles

et al. 2017

Blood Coagulation &Amp; Fibrinolysis

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Activated matrix metalloproteinase-8 in saliva as diagnostic test for periodontal disease? A case–control study

Borujeni

Mayer

Eickholz

2015

Med Microbiol Immunol

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Untreated periodontal disease may influence general health. However, how may a physician, who is not trained in periodontal probing, detect untreated periodontitis? Activated matrix metalloproteinase-8 (aMMP-8) in saliva correlates with periodontal probing parameters. Thus, sensitivity and specificity of a chair-side test for aMMP-8 to detect periodontitis were evaluated. Thirty cases [untreated chronic periodontitis (ChP); 15 generalized moderate and 15 generalized severe] and 30 controls [probing depths (PD) ≤3 mm, vertical probing attachment level (PAL-V) ≤2 mm at <30 % of sites) were examined periodontally (PD, PAL-V, bleeding on probing). Subsequently, the aMMP-8 test was performed. The test kit becomes positive with ≥25 ng/ml aMMP-8 in the sample. The aMMP-8 test was positive in 87 % of ChP and in 40 % of controls. That corresponds to a sensitivity of 87 % and a specificity of 60 %. The sensitivity to detect generalized severe ChP was 93 % (60 % specificity). Backward stepwise logistic regression analysis to explain positive aMMP-8 tests identified exclusively ChP with an odds ratio of 9.8 (p < 0.001). Positive results of the aMMP-8 test significantly correlate with generalized ChP. The aMMP-8 test may be used by physicians to detect periodontitis in their patients.

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Gingival bleeding is a useful clinical feature in the diagnosis of hereditary bleeding disorders in children

Edme,

Sola,

Cau-Diaz

et al. 2024

Eur J Pediatr

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Is gingival bleeding a symptom of patients with type 1 von Willebrand disease? A case–control study

Abstract: VWD is not associated with a more pronounced inflammatory response to the oral biofilm in terms of GBI and BOP.

Cited by 10 publications

References 21 publications

Gingival bleeding and mild type 1 von Willebrand disease

Gingival bleeding and mild type 1 von Willebrand disease

Activated matrix metalloproteinase-8 in saliva as diagnostic test for periodontal disease? A case–control study

Gingival bleeding is a useful clinical feature in the diagnosis of hereditary bleeding disorders in children

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