Gingival bleeding and mild type 1 von Willebrand disease

Weickert, Lisa; Krekeler, S.; Nickles, Katrin; Eickholz, Peter; Seifried, Erhard; Miesbach, Wolfgang

doi:10.1097/mbc.0000000000000526

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…[ 21 ] However, other scholars have suggested that gingival bleeding in VWD patients may be caused by gingival inflammation rather than a real symptom. [ 22 ] In this case, there was no uncontrollable bleeding during periodontal treatment, and the blood routine examination showed normal coagulation function. It is speculated that the child still has vwf gene mutation but does not show any symptoms.…”

Section: Discussionmentioning

confidence: 83%

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Tao,

Yao,

Dong

et al. 2024

Medicine

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Rationale: Severe congenital neutropenia (SCN) is a rare and heterogeneous genetic disease. By describing the diagnosis and treatment of a child with SCN and periodontitis, this case provides a reference for the oral health management of a child with SCN and periodontitis. Patient concerns: We describe a boy with clinical manifestations of oral bleeding, neutropenia, recurrent fever, and other recurrent infections. The absolute neutrophil count (ANC) was <0.50 × 109/L most of the time. Morphological examination of bone marrow cells showed active granulocyte hyperplasia and dysmaturation. Diagnoses: According to the clinical manifestations, hematological examination and gene detection results, the child was diagnosed as SCN with chronic periodontitis. Interventions: Periodontal treatment was performed after informed consent was obtained from the child guardian. These included supragingival and subgingival cleaning, hydrogen peroxide and saline irrigation, placement of iodoglycerin in the gingival sulcus, and oral hygiene instruction. Hematopoietic stem cell transplantation (HSCT) was performed later. Outcomes: One month after initial periodontal treatment, oral hygiene was well maintained and gingival swelling had subsided. Probing depth (PD) index on periodontal probing and bleeding was significantly reduced. However, there was no significant change in blood routine and other indicators before and after periodontal treatment. Conclusion: Once SCN is diagnosed, individualized treatment plans can be developed according to the characteristics of the disease and its impact on oral health, which can effectively control the interaction between SCN and periodontal disease and reduce the occurrence of serious infection.

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Section: Discussionmentioning

confidence: 83%

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Tao,

Yao,

Dong

et al. 2024

Medicine

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“…Studies have proven that hemophilic patients exhibit higher index values of gingival bleeding, plaque accumulation, and increased numbers of teeth affected by carious processes/extractions [20]. Nevertheless, no direct interrelationship has been detected between VWD and periodontal inflammation, as a reaction to the microorganism aggregation [17][18][19]. Another important aspect that should be considered is circulating blood cells profiles.…”

Section: Discussionmentioning

confidence: 99%

“…In the study of Weickert et al 2014 [17], BOP showed no major difference between the VWD group (14.5 ± 10.1%) and control (12.3 ± 5.3%). Weickert and coworkers 2017 [18], obtained BoP values of 17.0 ± 7.2% for the VWD group and 17.2 ± 7.6% for the control group. Epping et al [19] obtained BoP values of 14.5 ± 10.1% for the VWD group and 12.3 ± 5.3% for the control group.…”

Section: Qualitative Synthesismentioning

confidence: 92%

The Presence of Periodontitis in Patients with Von Willebrand Disease: A Systematic Review

Meşter¹,

Mancini²,

Marchetti³

et al. 2021

Applied Sciences

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The aim of this systematic review and meta-analysis was to analyze the available evidence on the assessment of periodontal disease in patients with von Willebrand disease (VWD). An electronic search in three databases (PubMed, Web of Science, and Scopus) was conducted by three independent reviewers to identify cross-sectional, cohort, and clinical trial studies. Studies considered eligible for this review were evaluated according to the quality and risk assessment tool proposed by the CLARITY Group at McMaster University. In order to analyze the possible correlation of VWD patients and periodontitis and their susceptibility to bleeding during the periodontal screening phase, periodontal parameters evaluated were probing pocket depth (PPD), bleeding on probing (BOP), gingival bleeding index (GBI), and periodontal inflamed surface area (PISA). After a screening of 562 articles, three articles were selected for the qualitative analysis. Within the limitation of our review, VWD patients are not more susceptible to periodontitis as compared with non-VWD patients. Nevertheless, bleeding on probing and gingival index needs to be carefully taken into consideration during periodontal screening of VWD due to the possible presence of false positives.

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Gingival bleeding and mild type 1 von Willebrand disease

Cited by 2 publications

References 24 publications

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

Oral health management in children with severe congenital neutropenia with periodontitis: Case report

The Presence of Periodontitis in Patients with Von Willebrand Disease: A Systematic Review

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