Is Genetic Screening Necessary for Determining the Possibility of Venous Thromboembolism in Cancer Patients?

Onur, Ece; Kurdal, Adnan Taner; Tuğrul, Berrin; Işkesen, İhsan; Dündar, Pınar Erbay; Taneli, Fatma; Ulman, Cevval; Var, Ahmet

doi:10.1159/000333394

Cited by 14 publications

(7 citation statements)

References 28 publications

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“…VV are more prevalent in populations of European origin than in those of African origin or Asians [1,5] . The risk factors for VV are age, family history, female sex, obesity, prolonged standing or walking, pregnancy, parity, deep vein thrombosis (DVT), surgery of the lower limbs, and a greater height [1,[6][7][8][9][10][11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Standing Posture at Work Does Not Increase the Risk of Varicose Veins among Health Care Providers in Taiwan

Huang

Weng

et al. 2017

Med Princ Pract

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Objective: This study compared the risk of varicose veins (VV) among physicians, nonphysician health care providers (HCP), and the general population. Subjects and Methods: The Taiwan National Health Insurance Research Database was used to identify 28,844 physicians and 26,099 nonphysician HCP and an identical number of age- and sex-matched patients from the general population. Using logistic regression analyses, VV risks between physicians and the general population, nonphysician HCP and the general population, and physicians and nonphysician HCP, and among physician specialists were compared by tracing their medical histories between 2007 and 2011. Results: Physicians and nonphysician HCP had cumulative VV incidences of 0.12% (34/28,844) and 0.13% (33/26,099), respectively, during the 5-year period, compared to that of the general population within the same 5-year period. Physicians and nonphysician HCP did not have a higher VV risk than the general population after adjusting for deep vein thrombosis (DVT) history (adjusted odds ratio [AOR] 0.86; 95% confidence interval [CI] 0.53-1.40, and AOR 1.43; 95% CI 0.82-2.50, respectively). Physicians did not a have higher VV risk than nonphysician HCP (AOR 0.80; 95% CI 0.43-1.51) after adjusting for age, sex, and DVT history. Surgery had the highest incidence (0.22%) while pediatrics and emergency medicine had the lowest incidence (0%) of VV risk among physician specialists; however, the difference was not significant (all p values >0.05). Conclusion: In this study, VV risk did not differ among physicians, nonphysician HCP, and the general population.

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Section: Introductionmentioning

confidence: 99%

Standing Posture at Work Does Not Increase the Risk of Varicose Veins among Health Care Providers in Taiwan

Huang

Weng

et al. 2017

Med Princ Pract

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“…In recent years, many investigations reported findings regarding potential associations between PAI-1 rs1799889 A/G polymorphism and VTE. [9][10][11][12] Nevertheless, these findings were somehow inconsistent.…”

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confidence: 99%

Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

Huang

Wang

et al. 2019

Clinical Cardiology

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BackgroundAssociation between plasminogen activator inhibitor‐1 (PAI‐1) rs1799889 polymorphism and venous thromboembolism (VTE) were explored by many previous studies, yet the findings of these studies were conflicting.Hypothesis PAI‐1 rs1799889 polymorphism may serve as a genetic marker of VTE. We aimed to better clarify the relationship between PAI‐1 rs1799889 polymorphism and VTE in a larger combined population by performing a meta‐analysis.MethodsLiteratures were searched in Pubmed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI). We used Review Manager to combine the results of individual studies.ResultsForty‐eight studies involving 14 806 participants were eligible for inclusion. Combined results revealed that PAI‐1 rs1799889 polymorphism was significantly associated with VTE in Caucasians (dominant comparison: odds ratio [OR] 1.20, 95% confidence interval [CI] 1.09‐1.32; recessive comparison: OR 0.84, 95% CI 0.76‐0.94; allele comparison: OR 1.08, 95% CI 1.02‐1.15) and East Asians (dominant comparison: OR 1.60, 95% CI 1.17‐2.19; allele comparison: OR 1.53, 95% CI 1.21‐1.93). Further analyses obtained similar significant associations in these with deep vein thrombosis (DVT) and these with Factor V Leiden mutation.ConclusionsOur findings supported that PAI‐1 rs1799889 polymorphism may serve as one of the predisposing factors of VTE in both Caucasians and East Asians, especially in these with DVT and these with Factor V Leiden mutation.

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“…Cancers were confirmed histologically or pathologically in most studies. Controls were mainly matched on sex and age, of which 17 were hospital based [21], [22], [23], [24], [29], [30], [31], [32], [33], [35], [36], [37], [38], [40], [41], [42], [43], 8 were population based [20], [25], [26], [27], [28], [34], [39]. Furthermore, 10 studies were conducted with subjects >500 in both case and control groups [20], [25], [26], [27], [28], [29], [34], [39], [40].…”

Section: Resultsmentioning

confidence: 99%

PAI-1 4G/5G Polymorphism Contributes to Cancer Susceptibility: Evidence from Meta-Analysis

Wang

Cao

Wang³

et al. 2013

PLoS ONE

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BackgroundThe plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and allows the modulation of cancer growth, invasion and angiogenesis. To date, studies investigated the association between a functional polymorphism in PAI-1 (4G/5G) and risk of cancer have shown inclusive results.MethodsA meta-analysis based on 25 case-control studies was performed to address this issue. Odds ratios (OR) with corresponding 95% confidence intervals (CIs) were used to assess the association. The statistical heterogeneity across studies was examined with I2 test.ResultsOverall, a significant increased risk of cancer was associated with the PAI-1 4G/4G polymorphism for the allele contrast (4G vs. 5G: OR = 1.10, CI = 1.03–1.18, I2 = 49.5%), the additive genetic model (4G/4G vs. 5G/5G: OR = 1.21, CI = 1.06–1.39, I2 = 51.9%), the recessive genetic model (4G/4G vs. 4G/5G+5G/5G: OR = 1.11, CI = 1.04–1.18, I2 = 20.8%). In the subgroup analysis by ethnicity, the results indicated that individuals with 4G/4G genotype had a significantly higher cancer risk among Caucasians (4G/4G vs. 5G/5G: OR = 1.31, 95%CI = 1.09–1.59, I2 = 59.6%; 4G/4G vs. 4G/5G: OR = 1.12, 95%CI = 1.04–1.21, I2 = 3.6%; recessive model: OR = 1.12, 95%CI = 1.05–1.21, I2 = 25.3%).ConclusionsThe results of the present meta-analysis support an association between the PAI-1 4G/5G polymorphism and increasing cancer risk, especially among Caucasians, and those with 4G allele have a high risk to develop colorectal cancer and endometrial cancer.

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Is Genetic Screening Necessary for Determining the Possibility of Venous Thromboembolism in Cancer Patients?

Cited by 14 publications

References 28 publications

Standing Posture at Work Does Not Increase the Risk of Varicose Veins among Health Care Providers in Taiwan

Standing Posture at Work Does Not Increase the Risk of Varicose Veins among Health Care Providers in Taiwan

Genetic association between plasminogen activator inhibitor‐1 rs1799889 polymorphism and venous thromboembolism: Evidence from a comprehensive meta‐analysis

PAI-1 4G/5G Polymorphism Contributes to Cancer Susceptibility: Evidence from Meta-Analysis

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