Is ethnicity a risk factor for severe retinopathy of prematurity?

Aralikatti, Anil; Mitra, Arijit; Denniston, Alastair K; Haque, Sayeed; Ewer, Andrew K; Butler, Lucilla

doi:10.1136/adc.2009.160366

Cited by 49 publications

(34 citation statements)

References 15 publications

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“…This has been previously noted in Asian Indians37 but the reason for this is unclear. Other differences, for example, rates of HMD and severe IVH were also noted.…”

Section: Discussionmentioning

confidence: 75%

The associations between ethnicity and outcomes of infants in neonatal intensive care units

Ruan

Abdel-Latif

Bajuk

et al. 2011

Arch Dis Child Fetal Neonatal Ed

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“…This has been previously noted in Asian Indians37 but the reason for this is unclear. Other differences, for example, rates of HMD and severe IVH were also noted.…”

Section: Discussionmentioning

confidence: 75%

The associations between ethnicity and outcomes of infants in neonatal intensive care units

Ruan

Abdel-Latif

Bajuk

et al. 2011

Arch Dis Child Fetal Neonatal Ed

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“…The reason for the racial differences observed is unclear. Some suggested explanations are (1) a higher rate of small-for-GA infants in Asian populations, (2) genetic variations and (3) pigmentation-related susceptibility to ischaemia-induced retinal vascularisation 21 24. Considering that infants of Korean origin have heavily pigmented fundi, the incidence of severe ROP among these infants, even among the more mature, is worthy of further attention.…”

Section: Discussionmentioning

confidence: 99%

Retinopathy of prematurity in Korean infants with birthweight greater than 1500 g

et al. 2015

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“…In prior studies [21, 28–32], race and ethnicity have also been identified as significant risk factors, with Whites [30, 32], Asians [31], and Alaskan Natives [28] found to be at increased risk of developing severe ROP. In the present study, we found that race/ethnicity was an independent predictor of any ROP and treatment-requiring ROP.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for retinopathy of prematurity: insights from outlier infants

Port

Chan

Ostmo

et al. 2014

Graefes Arch Clin Exp Ophthalmol

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Purpose To investigate the characteristics of outlier infants for insights into ROP risk. Methods Chart data were collected from 1354 infants screened for ROP at Weill Cornell Medical Center and Columbia University Medical Center. ROP exam results and clinical risk factors were recorded. The cohort was stratified by weight, highest ROP stage, and need for ROP treatment. Descriptive and correlational statistics were performed. Results For the overall cohort, regression analysis found that birth weight (OR: 0.741 per 100g; 95% CI: 0.606, 0.905), gestational age at birth (OR: 0.563 per week; 95% CI: 0.454, 0.697), multiple gestation (OR 2.02, 95% CI: 1.15, 3.56), bronchopulmonary dysplasia (OR: 4.68, 95% CI: 1.93, 11.35), and necrotizing enterocolitis (OR 2.80, 95% CI: 1.40, 5.16) were independent risk factors for treatment-requiring ROP. Black race was found to be a protective factor for treatment-requiring ROP (OR 0.244, 95% CI: 0.095, 0.626). Among 15 infants with BW <500g, there were no significant differences in any clinical risk factors between the 12 (80%) with ROP vs. the 3 (20%) without ROP. Similarly, among infants with BW >1500g, the 17 (9%) with ROP only differed from the 166 (91%) without ROP with respect to a higher incidence of necrotizing enterocolitis among those with ROP (11.8% vs 0%). Conclusions Although known clinical risk factors were predictive of ROP stage and need for laser treatment in this cohort, they were not significantly associated with ROP at extremes of birth weight. This suggests that other clinical, maternal, or genetic factors may protect from or predispose to ROP.

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Is ethnicity a risk factor for severe retinopathy of prematurity?

Abstract: Ethnicity is a risk factor for severe ROP. Asian and black infants have a higher risk of developing threshold ROP compared to white infants.

Cited by 49 publications

References 15 publications

The associations between ethnicity and outcomes of infants in neonatal intensive care units

The associations between ethnicity and outcomes of infants in neonatal intensive care units

Retinopathy of prematurity in Korean infants with birthweight greater than 1500 g

Risk factors for retinopathy of prematurity: insights from outlier infants

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