Is Endometrial Receptivity Assay (ERA) Useful in Patients with Repeated Implantation Failure Undergoing Single, Autologous Euploid Embryo Transfer?

Abstract

Background: Our aim in this study was to evaluate whether endometrial receptivity assay (ERA) test improves single, autologous euploid frozen-thawed embryo transfer (FET) outcomes in patients with repeated implantation failure. Methods: This was a retrospective cohort study which was conducted in a University affiliated private hospital. The study included 135 patients with repeated implantation failure who underwent single, autologous euploid ERA adjusted and non-adjusted FET. Patients were stratified into three groups, patients with receptive endometrium based on the ERA test, patients with non-receptive endometrium based on the ERA test and patients who did not receive the ERA test (control group). The three groups were compared in terms of FET outcomes. Results: Of 135 patients, 73 had the ERA test results available and 62 did not have the ERA test. Of 73 patients, 28 had non-receptive endometrium and 45 had receptive endometrium. The three groups are all the same in terms of age, body mass index, type of infertility, duration of infertility, number of previously embryo transfers and infertility causes (p > 0.05). Live birth rates were 46%, 50% and 51% for receptive, nonreceptive and control groups, respectively (p > 0.05). Implantation and clinical pregnancy rates were similar between the groups, as well. Conclusions: Adjusting the embryo transfer day according to the ERA test results seems to improve FET outcomes in patients with repeated implantation failure.

Assessing endometrial receptivity after recurrent implantation failure in euploid embryo transfer: a retrospective study in private clinic

“…One of the main causes of infertility is implantation failure, which has been associated with embryos with chromosomal alterations. Currently in assisted reproduction clinics, studies have been implemented to identify euploid embryos (without chromosomal alterations) and eliminate most of the genetically abnormal embryos to improve implantation rates and, therefore, the clinical pregnancy rate, such is the case of PGT-A, which in its latest versions uses NGS [18] . Despite this, a proportion of euploid embryos fail to implant, even if no structural pathology is identified in the uterus, which is why in recent years ERA is being implemented [19,20,21] .…”