Is Disseminated Juvenile Xanthogranulomatosis Benign Cephalic Histiocytosis?

Sidwell, Rachel U; Francis, N.; Slater, David; Mayou, S.C.

doi:10.1111/j.1525-1470.2005.22109.x

Cited by 34 publications

(28 citation statements)

References 16 publications

(31 reference statements)

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“…BCH must primarily be differentiated from micronodular form of JXG and GEH6,8. Furthermore, LCH, plane warts, urticaria pigmentosa, lichenoid sarcoidosis and multiple Spitz nevi can be confused with BCH.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, extracutaneous involvement occurs most significantly in the eyes. Histologic examination shows foamy cells and Touton giant cells8,9. GEH is more common in adults, with a more extensive distribution of lesions and occasional mucosal involvement.…”

Section: Discussionmentioning

confidence: 99%

“…Lesions of BCH was shown to transform into JXG in 2 cases15,16. Sidwell et al reported an infant with a congenital form of non-LCH with clinical and histologic features of both disseminated JXG and BCH8. A case of GEH was also reported many years after complete regression of BCH17.…”

Section: Discussionmentioning

confidence: 99%

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Benign Cephalic Histiocytosis: A Case Report

et al. 2011

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Histiocytic skin disorders are usually classified as either Langerhans' cell histiocytosis (LCH) or non LCH, based on the pathology. Benign cephalic histiocytosis (BCH) is a rare type of non-Langerhans histiocytitic disorder and is characterized by self-healing multiple small eruptions of yellow to red-brown papules on the face and upper trunk. Histologic features of this disorder show dermal proliferation of histiocytes that have intracytoplasmic comma-shaped bodies, coated vesicles and desmosome-like structures. In this study, we report on a 7-month-old boy who contained small yellow-red papules on his face that spread to his upper trunk. The clinical and histologic features in this patient were consistent with BCH.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Benign Cephalic Histiocytosis: A Case Report

et al. 2011

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“…Transformation of BCH lesions into JXG has been reported in 2 infants, aged 6 months6 and 1 year7, respectively. In addition, Sidwell et al reported a case of simultaneous occurrence of disseminated JXG and BCH8. These findings can be interpreted as being supportive of the hypothesis that BCH and JXG are different morphologic expressions of the same disease.…”

Section: Discussionmentioning

confidence: 65%

“…Spontaneous regression of the eruption is the rule; complete regression occurs within 50 months, on average. However, recent studies have suggested an association of BCH with other non-Langerhans cell histiocytosis disorders, and BCH is now regarded as a part of non-Langerhans cell histiocytosis in its clinical spectrum5-8. In general, BCH does not lead to abnormalities in laboratory test results, or have known complications.…”

Section: Discussionmentioning

confidence: 99%

A Case of Benign Cephalic Histiocytosis

et al. 2011

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Benign cephalic histiocytosis (BCH) is a rare non-Langerhans cell histiocytosis of unknown etiology. Clinically, lesions are characterized by small, red-to-yellow papules distributed mainly on the head, face, neck, and shoulders of infants and children. Histopathological specimens show massive histiocytic infiltration of the superficial dermis. Immunohistochemically, they are positive for CD68, but negative for CD1a and S-100. Two cases have been reported so far in the relevant work published in Korean literature. Herein, we report on an additional case of BCH.

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Cutaneous Histiocytoses

Tran,

Pope,

Weitzman

2016

Rook's Textbook of Dermatology, Ninth Edition

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Skin involvement is common in all forms of histiocytic disorders and is seen at all ages. In general, the histiocytoses can be divided into those involving dendritic cells and those involving the macrophage–monocyte lineage. Langerhans cell histiocytosis is the most common dendritic cell disorder and haemophagocytic lymphohistiocytosis the most common non‐dendritic disorder. Rarer disorders, the non‐Langerhans cell histiocytoses, can be divided into dendritic and non‐dendritic origin and each group further subdivided into those that mainly involve skin but occasionally have a systemic component and those that may include skin but in which the systemic component predominates. This chapter will provide an overview of histiocytic disorders including a brief discussion of possible pathogenetic mechanisms, followed by a more in‐depth discussion of the skin manifestations, pathology and therapy. The similarities and differences between childhood and adult forms of the diseases will be highlighted.

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Is Disseminated Juvenile Xanthogranulomatosis Benign Cephalic Histiocytosis?

Cited by 34 publications

References 16 publications

Benign Cephalic Histiocytosis: A Case Report

Benign Cephalic Histiocytosis: A Case Report

A Case of Benign Cephalic Histiocytosis

Cutaneous Histiocytoses

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