Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? –Results from a pilot study

Albrechtsen, Merete; Langeskov‐Christensen, Martin; Jørgensen, M.L.K.; Dalgas, Ulrik; Hansen, Mette

doi:10.1016/j.msard.2019.101921

Cited by 13 publications

(8 citation statements)

References 40 publications

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“…Finally, a higher proportion of fibers as the high nutrient quality carbohydrates (e.g., whole grain products) and a lower proportion of fat are able to improve physical activity and fatigue in pwMS as recently reported, whereas a high intake of sugar is related to an elevated serum insulin level, leading to inflammation and MS severity worsening [122].…”

Section: Western Diets (Wd)mentioning

confidence: 68%

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

et al. 2021

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Studies on the role of nutritional factors and physical activity (PA) in the pathogenesis of multiple sclerosis (MS) go back a long time. Despite the intrinsic difficulty of studying their positive or negative role in MS, the interest of researchers on these topics increased during the last few decades, since the role of diet has been investigated with the perspective of the association with disease-modifying drugs (DMD). The association of DMD, diets, and PA might have an additive effect in modifying disease severity. Among the various diets investigated (low-carbohydrate, gluten-free, Mediterranean, low-fat, fasting-mimicking, and Western diets) only low-carbohydrate, Mediterranean, and fast-mimicking diets have shown both in animal models and in humans a positive effect on MS course and in patient-reported outcomes (PROs). However, the Mediterranean diet is easier to be maintained compared to fast-mimicking and low-carbohydrate diets, which may lead to detrimental side effects requiring careful clinical monitoring. Conversely, the Western diet, which is characterized by a high intake of highly saturated fats and carbohydrates, may lead to the activation of pro-inflammatory immune pathways and is therefore not recommended. PA showed a positive effect both in animal models as well as on disease course and PROs in humans. Training with combined exercises is considered the more effective approach.

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Section: Western Diets (Wd)mentioning

confidence: 68%

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

et al. 2021

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“…30 Diğer bir çalışmada ise omega-3 alımı ile fiziksel yorgunluk arasında anlamlı derecede ters bir ilişki olduğu tespit edilmiş olup veriler çalışmamızı destekler nitelikte gözükmektedir. 31 Bu durum omega-3 yağ asitlerinin interlökin (IL)-6 duzeyini ve inflamasyonu azaltması ve oksidatif stresle alakalı NF-kβ aktivasyonunu inhibe etmesiyle ilişkilidir. Dolayısıyla bu durumun uyku homeostazisinin iyileştirilmesinde önemli olduğu belirtilmektedir.…”

Section: Bulgularunclassified

“…5,29 Çalışmamızda da uyku kalitesi kötüleştikçe yorgunluk düzeylerinin arttığı ve bu durumun düzelmesinde omega-3 yağ asitlerinin rolü olabileceği bildirilmiştir. 24,31 Tam tahıllardan kepekli ve tam buğday ekmeği tüketim miktarı ile PUKİ puanları arasında pozitif yönde anlamlı bir ilişki bulunmuştur (p<0,05). Tam tahıllar diyet lifi açısından zengin olduğundan, uyku kalitesi ve diyet lifi ile ilgili çalışmalar incelenmiştir.…”

Section: Bulgularunclassified

The Relationship Between Dietary Magnesium Intake and Sleep Quality and Fatigue: Cross-Sectional Study

ADIGÜZEL¹,

Erdem²,

Koçak³

2023

Turkiye Klinikleri J Health Sci

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Magnezyum DNA, RNA, protein ve adenozin trifosfat sentezi, hücresel enerji üretimi ve depolanması, glikoliz, hücresel ikincil haber sistemi, kas ve sinir fonksiyonu, kemik metabolizması, kan şekeri kontrolü ve kan basıncı regülasyonu gibi önemli metabolik yolaklarda hayati önem taşıyan enzimatik reaksiyonlar için bir kofaktör olarak görev alan esansiyel bir mineraldir. 1 Günlük beslenmemiz içinde

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“…A pilot study by Albrechtsen et al showed that fat consumption (33.9 ± 5.5% of total energy consumption) in the diet of MS patients was inversely related to physical performance (i.e. 6MWT -6-minute walk test and VO 2max ) [27]. Bromley et al, in a cross-sectional study, showed significant correlations between the percentage of fat intake from patients with improved distance traveled in 6MWT (r = 0.51, p = 0.02) and the results of the shortform health survey of 36 items (SF-36) (r = 0.47, p = 0.03), which means that diets with a higher fat content were positively correlated with improved mobility and quality of life in people with mild to moderate MS [28].…”

Section: Fatsmentioning

confidence: 99%

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

Zielińska¹,

Michońska²

2022

ppn

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Purpose: Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system in which multifocal damage to the brain and spinal cord occurs. The etiology of MS remains unclear but it is often recognized by researchers as a multifactorial disease that involves autoimmune and genetic predisposition combined with environmental influences (e.g., low vitamin D levels, smoking, obesity). An adequate and balanced diet can be extremely helpful in improving the condition of MS patients, effectively supporting pharmacological therapy. The purpose of the study was to investigate whether, and if so, to what extent, the intake of macronutrients, vitamins, and microelements may affect the course of MS. Views: The review presents data from studies published between 2017 and 2022. Conclusions: There are numerous studies on the role of specific dietary components in the treatment of MS, but the results are still limited. More work is needed to define the tools required for the assessment of patients' eating habits because dietary factors can affect the functioning and quality of life of MS patients and should therefore be evaluated to assist in comprehensive treatment and recovery.

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Is diet associated with physical capacity and fatigue in persons with multiple sclerosis? –Results from a pilot study

Cited by 13 publications

References 40 publications

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

The Role of Nutritional Lifestyle and Physical Activity in Multiple Sclerosis Pathogenesis and Management: A Narrative Review

The Relationship Between Dietary Magnesium Intake and Sleep Quality and Fatigue: Cross-Sectional Study

Macronutrients, vitamins and minerals in the diet of multiple sclerosis patients

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